UGT2B7 Antibody | Affinity Biosciences

Product:	UGT2B7 Antibody
Catalog:	DF12140
Description:	Rabbit polyclonal antibody to UGT2B7
Application:	WB IHC IF/ICC
Reactivity:	Human, Mouse, Rat
Prediction:	Sheep
Mol.Wt.:	55 kDa; 61kD(Calculated).
Uniprot:	P16662
RRID:	AB_2844945

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Blocking peptides are peptides that bind specifically to the target antibody and block antibody binding. These peptide usually contains the epitope recognized by the antibody. Antibodies bound to the blocking peptide no longer bind to the epitope on the target protein. By comparing the staining from the blocked antibody versus the antibody alone, one can see which staining is specific.

Size	Price	Inventory
100ul	$280	In stock
200ul	$350	In stock

Lead Time: Same day delivery

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Related Downloads

MS Report

HPLC Report

MSDS

Data Sheet

COA

Protocols

WB Handbook

IHC Protocol

IF/ICC Protocol

Product Info

Source:

Rabbit

Application:

WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

Reactivity:

Human,Mouse,Rat

Prediction:

Sheep(100%)

Clonality:

Polyclonal

Specificity:

UGT2B7 Antibody detects endogenous levels of total UGT2B7.

RRID:

AB_2844945
Cite Format: Affinity Biosciences Cat# DF12140, RRID:AB_2844945.

Conjugate:

Unconjugated.

Purification:

The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).

Storage:

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.

Alias:

Fold/Unfold

UDP glucuronosyltransferase 2 family, member B7; 3 4 catechol estrogen specific; 3; 3,4 catechol estrogen specific UDPGT; 4-catechol estrogen-specific UDPGT; UD2B7_HUMAN; UDP glucuronosyltransferase 2 family, polypeptide B7; UDP glucuronosyltransferase 2 family polypeptide B7; UDP glucuronosyltransferase 2 family, member B9; UDP glucuronosyltransferase 2B7; UDP glucuronosyltransferase2 family, polypeptide B7; UDP glucuronyltransferase family 2 beta 7; UDP glycosyltransferase 2 family polypeptide B7; UDP-glucuronosyltransferase 2B7; UDP-glucuronosyltransferase 2B9; UDPGT; UDPGT 2B7; UDPGT 2B9; UDPGT2B7; UDPGTh 2; UDPGTh-2; UDPGTh2; UGT2B7; UGT2B9; UGTB2B9; uridine diphosphate glycosyltransferase 2 family, member B7; uridine diphosphate glycosyltransferase 2 family, member B9;

Immunogens

Immunogen:

Uniprot:

P16662(UD2B7_HUMAN) >>Visit HPA database.

Gene(ID):

UGT2B7(7364)

Sequence:

P16662 UD2B7_HUMAN:
Protein BLAST With
NCBI/
ExPASy/
Uniprot

MSVKWTSVILLIQLSFCFSSGNCGKVLVWAAEYSHWMNIKTILDELIQRGHEVTVLASSASILFDPNNSSALKIEIYPTSLTKTELENFIMQQIKRWSDLPKDTFWLYFSQVQEIMSIFGDITRKFCKDVVSNKKFMKKVQESRFDVIFADAIFPCSELLAELFNIPFVYSLSFSPGYTFEKHSGGFIFPPSYVPVVMSELTDQMTFMERVKNMIYVLYFDFWFEIFDMKKWDQFYSEVLGRPTTLSETMGKADVWLIRNSWNFQFPYPLLPNVDFVGGLHCKPAKPLPKEMEDFVQSSGENGVVVFSLGSMVSNMTEERANVIASALAQIPQKVLWRFDGNKPDTLGLNTRLYKWIPQNDLLGHPKTRAFITHGGANGIYEAIYHGIPMVGIPLFADQPDNIAHMKARGAAVRVDFNTMSSTDLLNALKRVINDPSYKENVMKLSRIQHDQPVKPLDRAVFWIEFVMRHKGAKHLRVAAHDLTWFQYHSLDVIGFLLVCVATVIFIVTKCCLFCFWKFARKAKKGKND

Predictions

Predictions:

Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.

Species

Results

Score

Sheep

100

Pig

Horse

Bovine

Dog

Xenopus

Zebrafish

Chicken

Rabbit

Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

PTMs - P16662 As Substrate

P16662

Site	PTM Type	Enzyme	Source
N68	N-Glycosylation		Uniprot
Y236	Phosphorylation		Uniprot
K430	Acetylation		Uniprot
Y438	Phosphorylation	P12931 (SRC)	Uniprot
R469	Methylation		Uniprot

Research Backgrounds

P16662_UD2B7_HUMAN

Function:

UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds.

Its unique specificity for 3,4-catechol estrogens and estriol suggests it may play an important role in regulating the level and activity of these potent and active estrogen metabolites. Is also active with androsterone, hyodeoxycholic acid and tetrachlorocatechol (in vitro).

Subcellular Location:

Microsome membrane>Single-pass membrane protein. Endoplasmic reticulum membrane>Single-pass membrane protein.

Family&Domains:

Belongs to the UDP-glycosyltransferase family.

Research Fields

· Human Diseases > Cancers: Overview > Chemical carcinogenesis.

· Metabolism > Carbohydrate metabolism > Pentose and glucuronate interconversions.

· Metabolism > Carbohydrate metabolism > Ascorbate and aldarate metabolism.

· Metabolism > Lipid metabolism > Steroid hormone biosynthesis.

· Metabolism > Metabolism of cofactors and vitamins > Retinol metabolism.

· Metabolism > Metabolism of cofactors and vitamins > Porphyrin and chlorophyll metabolism.

· Metabolism > Xenobiotics biodegradation and metabolism > Metabolism of xenobiotics by cytochrome P450.

· Metabolism > Xenobiotics biodegradation and metabolism > Drug metabolism - cytochrome P450.

· Metabolism > Xenobiotics biodegradation and metabolism > Drug metabolism - other enzymes.

· Metabolism > Global and overview maps > Metabolic pathways.

References

1). The inhibition of tamoxifen on UGT2B gene expression and enzyme activity in rat liver contribute to the estrogen homeostasis dysregulation. BMC Pharmacology and Toxicology (PubMed: 35642027) [IF=2.9]

Restrictive clause

Affinity Biosciences tests all products strictly. Citations are provided as a resource for additional applications that have not been validated by Affinity Biosciences. Please choose the appropriate format for each application and consult Materials and Methods sections for additional details about the use of any product in these publications.

For Research Use Only.
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UGT2B7 Antibody - #DF12140