GLUD1 Antibody - #DF12116
Product: | GLUD1 Antibody |
Catalog: | DF12116 |
Description: | Rabbit polyclonal antibody to GLUD1 |
Application: | WB IHC |
Reactivity: | Human, Mouse, Rat |
Prediction: | Bovine, Sheep, Rabbit, Chicken, Xenopus |
Mol.Wt.: | 45-55 kDa; 61kD(Calculated). |
Uniprot: | P00367 |
RRID: | AB_2844921 |
Related Downloads
Protocols
Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# DF12116, RRID:AB_2844921.
Fold/Unfold
AI118167; DHE3_HUMAN; EC 1.4.1.3; GDH 1; GDH; Gdh-X; GDH1; GLUD; Glud1; Glud1a; Glud1b; Gludl; Glutamate dehydrogenase (NAD(P)+); Glutamate dehydrogenase 1; Glutamate dehydrogenase 1 mitochondrial; Glutamate dehydrogenase 1a; Glutamate dehydrogenase 1b; Memory-related gene 2 protein; MGC127177; MGC132003; MGC80801; MGC93608; mitochondrial; MRG-2;
Immunogens
- P00367 DHE3_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MYRYLGEALLLSRAGPAALGSASADSAALLGWARGQPAAAPQPGLALAARRHYSEAVADREDDPNFFKMVEGFFDRGASIVEDKLVEDLRTRESEEQKRNRVRGILRIIKPCNHVLSLSFPIRRDDGSWEVIEGYRAQHSQHRTPCKGGIRYSTDVSVDEVKALASLMTYKCAVVDVPFGGAKAGVKINPKNYTDNELEKITRRFTMELAKKGFIGPGIDVPAPDMSTGEREMSWIADTYASTIGHYDINAHACVTGKPISQGGIHGRISATGRGVFHGIENFINEASYMSILGMTPGFGDKTFVVQGFGNVGLHSMRYLHRFGAKCIAVGESDGSIWNPDGIDPKELEDFKLQHGSILGFPKAKPYEGSILEADCDILIPAASEKQLTKSNAPRVKAKIIAEGANGPTTPEADKIFLERNIMVIPDLYLNAGGVTVSYFEWLKNLNHVSYGRLTFKYERDSNYHLLMSVQESLERKFGKHGGTIPIVPTAEFQDRISGASEKDIVHSGLAYTMERSARQIMRTAMKYNLGLDLRTAAYVNAIEKVFKVYNEAGVTFT
Predictions
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - P00367 As Substrate
Site | PTM Type | Enzyme | Source |
---|---|---|---|
K68 | Acetylation | Uniprot | |
R76 | Methylation | Uniprot | |
S79 | Phosphorylation | Uniprot | |
K84 | Acetylation | Uniprot | |
K84 | Ubiquitination | Uniprot | |
K98 | Acetylation | Uniprot | |
C112 | S-Nitrosylation | Uniprot | |
S128 | Phosphorylation | Uniprot | |
Y135 | Phosphorylation | Uniprot | |
S153 | Phosphorylation | Uniprot | |
T154 | Phosphorylation | Uniprot | |
S157 | Phosphorylation | Uniprot | |
K162 | Acetylation | Uniprot | |
K162 | Ubiquitination | Uniprot | |
Y170 | Phosphorylation | Uniprot | |
K171 | Methylation | Uniprot | |
K183 | Sumoylation | Uniprot | |
K183 | Ubiquitination | Uniprot | |
K187 | Ubiquitination | Uniprot | |
K191 | Ubiquitination | Uniprot | |
T194 | Phosphorylation | Uniprot | |
K200 | Ubiquitination | Uniprot | |
T206 | Phosphorylation | Uniprot | |
K211 | Acetylation | Uniprot | |
K211 | Ubiquitination | Uniprot | |
K212 | Ubiquitination | Uniprot | |
S227 | Phosphorylation | Uniprot | |
T228 | Phosphorylation | Uniprot | |
K302 | Methylation | Uniprot | |
S316 | Phosphorylation | Uniprot | |
S333 | Phosphorylation | Uniprot | |
S336 | Phosphorylation | Uniprot | |
K346 | Acetylation | Uniprot | |
K352 | Acetylation | Uniprot | |
K352 | Ubiquitination | Uniprot | |
S357 | Phosphorylation | Uniprot | |
K363 | Ubiquitination | Uniprot | |
K365 | Ubiquitination | Uniprot | |
Y367 | Phosphorylation | Uniprot | |
S370 | Phosphorylation | Uniprot | |
S384 | Phosphorylation | Uniprot | |
K386 | Ubiquitination | Uniprot | |
K390 | Acetylation | Uniprot | |
K390 | Ubiquitination | Uniprot | |
K399 | Ubiquitination | Uniprot | |
T409 | Phosphorylation | Uniprot | |
T410 | Phosphorylation | Uniprot | |
K415 | Acetylation | Uniprot | |
K415 | Ubiquitination | Uniprot | |
S438 | Phosphorylation | Uniprot | |
Y439 | Phosphorylation | Uniprot | |
S450 | Phosphorylation | Uniprot | |
Y451 | Phosphorylation | Uniprot | |
K457 | Acetylation | Uniprot | |
S462 | Phosphorylation | Uniprot | |
Y464 | Phosphorylation | Uniprot | |
K480 | Acetylation | Uniprot | |
K480 | Ubiquitination | Uniprot | |
R496 | Methylation | Uniprot | |
K503 | Acetylation | Uniprot | |
K503 | Ubiquitination | Uniprot | |
Y512 | Phosphorylation | Uniprot | |
T513 | Phosphorylation | Uniprot | |
K527 | Acetylation | Uniprot | |
K527 | Ubiquitination | Uniprot | |
Y528 | Phosphorylation | Uniprot | |
Y539 | Phosphorylation | Uniprot | |
K545 | Acetylation | Uniprot | |
K545 | Ubiquitination | Uniprot | |
Y550 | Phosphorylation | Uniprot |
Research Backgrounds
Mitochondrial glutamate dehydrogenase that converts L-glutamate into alpha-ketoglutarate. Plays a key role in glutamine anaplerosis by producing alpha-ketoglutarate, an important intermediate in the tricarboxylic acid cycle. May be involved in learning and memory reactions by increasing the turnover of the excitatory neurotransmitter glutamate (By similarity).
ADP-ribosylated by SIRT4, leading to inactivate glutamate dehydrogenase activity (By similarity). Stoichiometry shows that ADP-ribosylation occurs in one subunit per catalytically active homohexamer.
Mitochondrion matrix.
Homohexamer.
Belongs to the Glu/Leu/Phe/Val dehydrogenases family.
Research Fields
· Cellular Processes > Cell growth and death > Necroptosis. (View pathway)
· Metabolism > Amino acid metabolism > Arginine biosynthesis.
· Metabolism > Amino acid metabolism > Alanine, aspartate and glutamate metabolism.
· Metabolism > Metabolism of other amino acids > D-Glutamine and D-glutamate metabolism.
· Metabolism > Energy metabolism > Nitrogen metabolism.
· Metabolism > Global and overview maps > Metabolic pathways.
· Metabolism > Global and overview maps > Carbon metabolism.
· Organismal Systems > Excretory system > Proximal tubule bicarbonate reclamation.
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