DHRS3 Antibody - #DF12070
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Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# DF12070, RRID:AB_2844875.
Fold/Unfold
DD83.1; Dehydrogenase/reductase (SDR family) member 3; DHRS3; DHRS3_HUMAN; EC 1.1.1.300; MGC125166; RDH17; Retinal short chain dehydrogenase/reductase 1; Retinal short-chain dehydrogenase/reductase 1; retSDR1; Rsdr1; SDR family, member 3; SDR1; SDR16C1; Short-chain dehydrogenase/reductase 3; Short-chain dehydrogenase/reductase family, member 3;
Immunogens
Widely expressed with highest levels found in heart, placenta, lung, liver, kidney, pancreas, thyroid, testis, stomach, trachea and spinal cord. Lower levels found in skeletal muscle, intestine and lymph node. No expression detected in brain. In the retina, expressed in cone but not rod outer segments.
- O75911 DHRS3_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MVWKRLGALVMFPLQMIYLVVKAAVGLVLPAKLRDLSRENVLITGGGRGIGRQLAREFAERGARKIVLWGRTEKCLKETTEEIRQMGTECHYFICDVGNREEVYQTAKAVREKVGDITILVNNAAVVHGKSLMDSDDDALLKSQHINTLGQFWTTKAFLPRMLELQNGHIVCLNSVLALSAIPGAIDYCTSKASAFAFMESLTLGLLDCPGVSATTVLPFHTSTEMFQGMRVRFPNLFPPLKPETVARRTVEAVQLNQALLLLPWTMHALVILKSILPQAALEEIHKFSGTYTCMNTFKGRT
Predictions
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - O75911 As Substrate
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| K32 | Ubiquitination | Uniprot | |
| R48 | Methylation | Uniprot | |
| K108 | Ubiquitination | Uniprot | |
| K130 | Ubiquitination | Uniprot | |
| S135 | Phosphorylation | Uniprot | |
| K142 | Ubiquitination | Uniprot | |
| K156 | Ubiquitination | Uniprot | |
| K242 | Ubiquitination | Uniprot | |
| K299 | Ubiquitination | Uniprot |
Research Backgrounds
Catalyzes the reduction of all-trans-retinal to all-trans-retinol in the presence of NADPH.
Membrane>Multi-pass membrane protein.
Widely expressed with highest levels found in heart, placenta, lung, liver, kidney, pancreas, thyroid, testis, stomach, trachea and spinal cord. Lower levels found in skeletal muscle, intestine and lymph node. No expression detected in brain. In the retina, expressed in cone but not rod outer segments.
Belongs to the short-chain dehydrogenases/reductases (SDR) family.
Research Fields
· Metabolism > Metabolism of cofactors and vitamins > Retinol metabolism.
· Metabolism > Global and overview maps > Metabolic pathways.
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