PYCR1 Antibody - #DF12051
| Product: | PYCR1 Antibody |
| Catalog: | DF12051 |
| Description: | Rabbit polyclonal antibody to PYCR1 |
| Application: | WB IHC IF/ICC |
| Reactivity: | Human, Mouse, Rat |
| Prediction: | Pig, Bovine, Horse, Sheep, Dog, Xenopus |
| Mol.Wt.: | 33 kDa, 35 kDa; 33kD(Calculated). |
| Uniprot: | P32322 |
| RRID: | AB_2844856 |
Related Downloads
Protocols
Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# DF12051, RRID:AB_2844856.
Fold/Unfold
P5C; P5C reductase 1; P5C reductase; P5CR 1; P5CR; PIG45; PP222; Proliferation inducing protein 45; PYCR 1; PYCR; Pyrroline 5 carboxylate reductase 1; Pyrroline 5 carboxylate reductase 1 mitochondrial;
Immunogens
- P32322 P5CR1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MSVGFIGAGQLAFALAKGFTAAGVLAAHKIMASSPDMDLATVSALRKMGVKLTPHNKETVQHSDVLFLAVKPHIIPFILDEIGADIEDRHIVVSCAAGVTISSIEKKLSAFRPAPRVIRCMTNTPVVVREGATVYATGTHAQVEDGRLMEQLLSSVGFCTEVEEDLIDAVTGLSGSGPAYAFTALDALADGGVKMGLPRRLAVRLGAQALLGAAKMLLHSEQHPGQLKDNVSSPGGATIHALHVLESGGFRSLLINAVEASCIRTRELQSMADQEQVSPAAIKKTILDKVKLDSPAGTALSPSGHTKLLPRSLAPAGKD
Predictions
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - P32322 As Substrate
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S2 | Acetylation | Uniprot | |
| K51 | Ubiquitination | Uniprot | |
| K215 | Acetylation | Uniprot | |
| K215 | Ubiquitination | Uniprot | |
| K228 | Ubiquitination | Uniprot | |
| S233 | Phosphorylation | Uniprot | |
| T238 | Phosphorylation | Uniprot | |
| S261 | Phosphorylation | Uniprot | |
| C262 | S-Nitrosylation | Uniprot | |
| S270 | Phosphorylation | Uniprot | |
| S278 | Phosphorylation | Uniprot | |
| K283 | Ubiquitination | Uniprot | |
| K289 | Ubiquitination | Uniprot | |
| K291 | Ubiquitination | Uniprot | |
| S294 | Phosphorylation | Uniprot | |
| T298 | Phosphorylation | Uniprot | |
| S301 | Phosphorylation | P24941 (CDK2) | Uniprot |
| S303 | Phosphorylation | P24941 (CDK2) | Uniprot |
Research Backgrounds
Housekeeping enzyme that catalyzes the last step in proline biosynthesis. Can utilize both NAD and NADP, but has higher affinity for NAD. Involved in the cellular response to oxidative stress.
Mitochondrion.
Homodecamer; composed of 5 homodimers Ref.18). Interacts with LTO1.
Belongs to the pyrroline-5-carboxylate reductase family.
Research Fields
· Metabolism > Amino acid metabolism > Arginine and proline metabolism.
· Metabolism > Global and overview maps > Metabolic pathways.
· Metabolism > Global and overview maps > Biosynthesis of amino acids.
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For Research Use Only.
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