Product: Parathyroid Hormone Antibody
Catalog: AF0234
Description: Rabbit polyclonal antibody to Parathyroid Hormone
Application: WB IF/ICC
Reactivity: Human
Prediction: Pig, Bovine, Horse, Rabbit, Dog
Mol.Wt.: 16kDa; 13kD(Calculated).
Uniprot: P01270
RRID: AB_2833409

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 100ul $280 In stock
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Product Info

Source:
Rabbit
Application:
WB 1:500-1:3000, IF/ICC 1:100-1:500
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

Reactivity:
Human
Prediction:
Pig(93%), Bovine(87%), Horse(93%), Rabbit(86%), Dog(80%)
Clonality:
Polyclonal
Specificity:
Parathyroid Hormone Antibody detects endogenous levels of total Parathyroid Hormone.
RRID:
AB_2833409
Cite Format: Affinity Biosciences Cat# AF0234, RRID:AB_2833409.
Conjugate:
Unconjugated.
Purification:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
Storage:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
Alias:

Fold/Unfold

hPTH; Parathormone; Parathyrin; Parathyroid hormone 1; Parathyroid hormone; Prepro PTH; Preproparathyroid hormone; PTH; PTH1; PTH1 receptor; PTH1R; PTHR; PTHR1; PTHY_HUMAN;

Immunogens

Immunogen:
Uniprot:
Gene(ID):
Description:
PTH PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion. Belongs to the parathyroid hormone family.
Sequence:
MIPAKDMAKVMIVMLAICFLTKSDGKSVKKRSVSEIQLMHNLGKHLNSMERVEWLRKKLQDVHNFVALGAPLAPRDAGSQRPRKKEDNVLVESHEKSLGEADKADVNVLTKAKSQ

Predictions

Predictions:

Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.

Species
Results
Score
Pig
93
Horse
93
Bovine
87
Rabbit
86
Dog
80
Sheep
73
Chicken
73
Xenopus
0
Zebrafish
0
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

PTMs - P01270 As Substrate

Site PTM Type Enzyme
T21 Phosphorylation
S23 Phosphorylation
S32 Phosphorylation
S34 Phosphorylation
S48 Phosphorylation

Research Backgrounds

Function:

PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion. Stimulates [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblastic cells.

Subcellular Location:

Secreted.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
Subunit Structure:

Interacts with PTH1R (via N-terminal extracellular domain).

Family&Domains:

Belongs to the parathyroid hormone family.

References

1). Design, semi-synthesis and bioactivity evaluation of novel podophyllotoxin derivatives as potent anti-tumor agents. Bioorganic Chemistry, 2022 (PubMed: 35661529) [IF=5.1]

Restrictive clause

 

Affinity Biosciences tests all products strictly. Citations are provided as a resource for additional applications that have not been validated by Affinity Biosciences. Please choose the appropriate format for each application and consult Materials and Methods sections for additional details about the use of any product in these publications.

For Research Use Only.
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