Phospho-CD226/DNAM-1 (Ser329) Antibody - #AF4478
| Product: | Phospho-CD226/DNAM-1 (Ser329) Antibody |
| Catalog: | AF4478 |
| Description: | Rabbit polyclonal antibody to Phospho-CD226/DNAM-1 (Ser329) |
| Application: | WB IHC |
| Reactivity: | Human, Mouse, Monkey |
| Prediction: | Pig, Horse |
| Mol.Wt.: | 58kDa; 39kD(Calculated). |
| Uniprot: | Q15762 |
| RRID: | AB_2844641 |
Related Downloads
Protocols
Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# AF4478, RRID:AB_2844641.
Fold/Unfold
adhesion glycoprotein; CD226; CD226 antigen; CD226 molecule; CD226_HUMAN; DNAM 1; DNAM-1; DNAM1; DNAX accessory molecule 1; platelet and T cell activation antigen 1; PTA1; T lineage specific activation antigen 1 antigen; TLiSA1;
Immunogens
- Q15762 CD226_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MDYPTLLLALLHVYRALCEEVLWHTSVPFAENMSLECVYPSMGILTQVEWFKIGTQQDSIAIFSPTHGMVIRKPYAERVYFLNSTMASNNMTLFFRNASEDDVGYYSCSLYTYPQGTWQKVIQVVQSDSFEAAVPSNSHIVSEPGKNVTLTCQPQMTWPVQAVRWEKIQPRQIDLLTYCNLVHGRNFTSKFPRQIVSNCSHGRWSVIVIPDVTVSDSGLYRCYLQASAGENETFVMRLTVAEGKTDNQYTLFVAGGTVLLLLFVISITTIIVIFLNRRRRRERRDLFTESWDTQKAPNNYRSPISTSQPTNQSMDDTREDIYVNYPTFSRRPKTRV
Predictions
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q15762 As Substrate
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| K167 | Ubiquitination | Uniprot | |
| Y249 | Phosphorylation | Uniprot | |
| T250 | Phosphorylation | Uniprot | |
| S290 | Phosphorylation | Uniprot | |
| T293 | Phosphorylation | Uniprot | |
| K295 | Ubiquitination | Uniprot | |
| S313 | Phosphorylation | Uniprot | |
| Y322 | Phosphorylation | P06241 (FYN) | Uniprot |
| Y325 | Phosphorylation | Uniprot | |
| S329 | Phosphorylation | P17252 (PRKCA) | Uniprot |
Research Backgrounds
Involved in intercellular adhesion, lymphocyte signaling, cytotoxicity and lymphokine secretion mediated by cytotoxic T-lymphocyte (CTL) and NK cell. Cell surface receptor for NECTIN2. Upon ligand binding, stimulates T-cell proliferation and cytokine production, including that of IL2, IL5, IL10, IL13, and IFNG. Competes with PVRIG for NECTIN2-binding.
Cell membrane>Single-pass type I membrane protein.
Expressed by peripheral blood T-lymphocytes.
Interacts with PVR and NECTIN2. Competes with PVRIG for NECTIN2-binding.
Research Fields
· Environmental Information Processing > Signaling molecules and interaction > Cell adhesion molecules (CAMs). (View pathway)
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