Oxytocin Receptor Antibody | Affinity Biosciences

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Western blot analysis of Oxytocin Receptor in lysates of PC-3 , using Oxytocin Receptor Antibody(AF4667).

Product:	Oxytocin Receptor Antibody
Catalog:	AF4667
Description:	Rabbit polyclonal antibody to Oxytocin Receptor
Application:	WB
Reactivity:	Human, Mouse, Rat
Prediction:	Pig, Bovine, Horse, Sheep, Rabbit, Dog
Mol.Wt.:	43 kDa; 43kD(Calculated).
Uniprot:	P30559
RRID:	AB_2844593

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Blocking peptides are peptides that bind specifically to the target antibody and block antibody binding. These peptide usually contains the epitope recognized by the antibody. Antibodies bound to the blocking peptide no longer bind to the epitope on the target protein. By comparing the staining from the blocked antibody versus the antibody alone, one can see which staining is specific.

Size	Price	Inventory
50ul	$250	In stock
100ul	$350	In stock
200ul	$450	In stock

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Related Downloads

MSDS

Data Sheet

COA

Protocols

WB Handbook

IHC Protocol

IF/ICC Protocol

Product Info

Source:

Rabbit

Application:

WB 1:500-1:2000
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

Reactivity:

Human,Mouse,Rat

Prediction:

Pig(100%), Bovine(100%), Horse(100%), Sheep(100%), Rabbit(100%), Dog(100%)

Clonality:

Polyclonal

Specificity:

Oxytocin Receptor Antibody detects endogenous levels of total Oxytocin Receptor.

RRID:

AB_2844593
Cite Format: Affinity Biosciences Cat# AF4667, RRID:AB_2844593.

Conjugate:

Unconjugated.

Purification:

The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).

Storage:

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.

Alias:

Fold/Unfold

OT R; OT-R; OTR 1; OTR; OTR1; OXT R; Oxtr; OXYR_HUMAN; Oxytocin receptor;

Immunogens

Immunogen:

Uniprot:

P30559(OXYR_HUMAN) >>Visit HPA database.

Gene(ID):

OXTR(5021)

Sequence:

P30559 OXYR_HUMAN:
Protein BLAST With
NCBI/
ExPASy/
Uniprot

MEGALAANWSAEAANASAAPPGAEGNRTAGPPRRNEALARVEVAVLCLILLLALSGNACVLLALRTTRQKHSRLFFFMKHLSIADLVVAVFQVLPQLLWDITFRFYGPDLLCRLVKYLQVVGMFASTYLLLLMSLDRCLAICQPLRSLRRRTDRLAVLATWLGCLVASAPQVHIFSLREVADGVFDCWAVFIQPWGPKAYITWITLAVYIVPVIVLAACYGLISFKIWQNLRLKTAAAAAAEAPEGAAAGDGGRVALARVSSVKLISKAKIRTVKMTFIIVLAFIVCWTPFFFVQMWSVWDANAPKEASAFIIVMLLASLNSCCNPWIYMLFTGHLFHELVQRFLCCSASYLKGRRLGETSASKKSNSSSFVLSHRSSSQRSCSQPSTA

Predictions

Predictions:

Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.

Species

Results

Score

Pig

100

Horse

100

Bovine

100

Sheep

100

Dog

100

Rabbit

100

Xenopus

Zebrafish

Chicken

Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

PTMs - P30559 As Substrate

P30559

Site	PTM Type	Source
K234	Ubiquitination	Uniprot
T235	Phosphorylation	Uniprot
S366	Phosphorylation	Uniprot
S370	Phosphorylation	Uniprot

Research Backgrounds

P30559_OXYR_HUMAN

Function:

Receptor for oxytocin. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system.

Subcellular Location:

Cell membrane>Multi-pass membrane protein.

Family&Domains:

Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.

Research Fields

· Environmental Information Processing > Signal transduction > Calcium signaling pathway. (View pathway)

· Environmental Information Processing > Signal transduction > cAMP signaling pathway. (View pathway)

· Environmental Information Processing > Signaling molecules and interaction > Neuroactive ligand-receptor interaction.

· Organismal Systems > Endocrine system > Oxytocin signaling pathway.

References

1). In need of a specific antibody against the oxytocin receptor for neuropsychiatric research: A KO validation study. Journal of psychiatric research, 2024 (PubMed: 38554622) [IF=4.8]

Restrictive clause

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For Research Use Only.
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Oxytocin Receptor Antibody - #AF4667