LAB Antibody - #DF10355

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Product: LAB Antibody
Catalog: DF10355
Description: Rabbit polyclonal antibody to LAB
Application: WB
Reactivity: Human, Mouse
Prediction: Pig, Bovine, Horse, Sheep, Dog
Mol.Wt.: 26KD; 27kD(Calculated).
Uniprot: Q9GZY6
RRID: AB_2844362

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 100ul $280 In stock
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Related Downloads
MS Report
HPLC Report
MSDS
Data Sheet
COA
Protocols
WB Handbook
IHC Protocol
IF/ICC Protocol

Product Info

Source:
Rabbit
Application:
WB 1:500-1:2000
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

Reactivity:
Human,Mouse
Prediction:
Pig(100%), Bovine(100%), Horse(100%), Sheep(100%), Dog(100%)
Clonality:
Polyclonal
Specificity:
LAB Antibody detects endogenous levels of total LAB.
RRID:
AB_2844362
Cite Format: Affinity Biosciences Cat# DF10355, RRID:AB_2844362.
Conjugate:
Unconjugated.
Purification:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
Storage:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
Alias:

Fold/Unfold

HSPC046; LAB; LAT2; Linker for activation of B cells; Linker for activation of B-cells; Linker for activation of T cells family member 2; Linker for activation of T cells transmembrane adaptor 2; Linker for activation of T-cells family member 2; Membrane associated adapter molecule; Membrane-associated adapter molecule; Non T cell activation linker; Non-T-cell activation linker; NTAL_HUMAN; WBSCR 5; Wbscr15; Williams Beuren syndrome chromosome region 15; Williams Beuren syndrome chromosome region 5; Williams-Beuren syndrome chromosomal region 15 protein; Williams-Beuren syndrome chromosomal region 5 protein; WSCR5;

Immunogens

Immunogen:
Uniprot:

Q9GZY6(NTAL_HUMAN) >>Visit HPA database.

Gene(ID):
LAT2(7462)
Expression:
Q9GZY6 NTAL_HUMAN:

Highly expressed in spleen, peripheral blood lymphocytes, and germinal centers of lymph nodes. Also expressed in placenta, lung, pancreas and small intestine. Present in B-cells, NK cells and monocytes. Absent from T-cells (at protein level).

Sequence:
MSSGTELLWPGAALLVLLGVAASLCVRCSRPGAKRSEKIYQQRSLREDQQSFTGSRTYSLVGQAWPGPLADMAPTRKDKLLQFYPSLEDPASSRYQNFSKGSRHGSEEAYIDPIAMEYYNWGRFSKPPEDDDANSYENVLICKQKTTETGAQQEGIGGLCRGDLSLSLALKTGPTSGLCPSASPEEDEESEDYQNSASIHQWRESRKVMGQLQREASPGPVGSPDEEDGEPDYVNGEVAATEA

Predictions

Predictions:

Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.

Species
Results
Score
Pig
100
Horse
100
Bovine
100
Sheep
100
Dog
100
Chicken
63
Xenopus
0
Zebrafish
0
Rabbit
0
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

PTMs - Q9GZY6 As Substrate

Site PTM Type Enzyme
Y40 Phosphorylation
S44 Phosphorylation
S51 Phosphorylation
S55 Phosphorylation
T57 Phosphorylation
Y58 Phosphorylation
S59 Phosphorylation
K77 Ubiquitination
K79 Ubiquitination
Y84 Phosphorylation
S86 Phosphorylation
Y95 Phosphorylation P07948 (LYN)
K100 Ubiquitination
S102 Phosphorylation
S106 Phosphorylation
Y110 Phosphorylation P10721 (KIT) , P07948 (LYN)
Y118 Phosphorylation P10721 (KIT) , P07948 (LYN)
Y119 Phosphorylation P07948 (LYN)
K126 Ubiquitination
S135 Phosphorylation
Y136 Phosphorylation P07948 (LYN) , P43405 (SYK)
S167 Phosphorylation
S183 Phosphorylation
S190 Phosphorylation
Y193 Phosphorylation P43405 (SYK)
S196 Phosphorylation
S198 Phosphorylation
S205 Phosphorylation
S217 Phosphorylation
Y233 Phosphorylation P43405 (SYK)

Research Backgrounds

Function:

Involved in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. May also be involved in BCR (B-cell antigen receptor)-mediated signaling in B-cells and FCGR1 (high affinity immunoglobulin gamma Fc receptor I)-mediated signaling in myeloid cells. Couples activation of these receptors and their associated kinases with distal intracellular events through the recruitment of GRB2.

PTMs:

Phosphorylated on tyrosines following cross-linking of BCR in B-cells, FCGR1 in myeloid cells, or FCER1 in mast cells; which induces the recruitment of GRB2.

May be polyubiquitinated.

Subcellular Location:

Cell membrane>Single-pass type III membrane protein.
Note: Present in lipid rafts.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
Tissue Specificity:

Highly expressed in spleen, peripheral blood lymphocytes, and germinal centers of lymph nodes. Also expressed in placenta, lung, pancreas and small intestine. Present in B-cells, NK cells and monocytes. Absent from T-cells (at protein level).

Subunit Structure:

When phosphorylated, interacts with GRB2. May also interact with SOS1, GAB1 and CBL.

Restrictive clause

 

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