Phospho-ADAM9 (Thr761) Antibody - #AF7059
| Product: | Phospho-ADAM9 (Thr761) Antibody |
| Catalog: | AF7059 |
| Description: | Rabbit polyclonal antibody to Phospho-ADAM9 (Thr761) |
| Application: | WB IHC |
| Reactivity: | Human, Mouse, Rat |
| Prediction: | Pig, Horse, Rabbit |
| Mol.Wt.: | 91kDa,105kDa; 91kD(Calculated). |
| Uniprot: | Q13443 |
| RRID: | AB_2843499 |
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Protocols
Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# AF7059, RRID:AB_2843499.
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A disintegrin and metalloproteinase domain 9; ADAM 9; ADAM metallopeptidase domain 9; Cellular disintegrin related protein; Cone rod dystrophy 9; CORD9; Disintegrin and metalloproteinase domain 9; Disintegrin and metalloproteinase domain containing protein 9; KIAA0021; MCMP; MDC 9; MDC9; Meltrin gamma; Metalloprotease disintegrin cysteine rich protein 9; Mltng; Myeloma cell metalloproteinase;
Immunogens
Widely expressed. Expressed in chondrocytes. Isoform 2 is highly expressed in liver and heart.
- Q13443 ADAM9_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MGSGARFPSGTLRVRWLLLLGLVGPVLGAARPGFQQTSHLSSYEIITPWRLTRERREAPRPYSKQVSYVIQAEGKEHIIHLERNKDLLPEDFVVYTYNKEGTLITDHPNIQNHCHYRGYVEGVHNSSIALSDCFGLRGLLHLENASYGIEPLQNSSHFEHIIYRMDDVYKEPLKCGVSNKDIEKETAKDEEEEPPSMTQLLRRRRAVLPQTRYVELFIVVDKERYDMMGRNQTAVREEMILLANYLDSMYIMLNIRIVLVGLEIWTNGNLINIVGGAGDVLGNFVQWREKFLITRRRHDSAQLVLKKGFGGTAGMAFVGTVCSRSHAGGINVFGQITVETFASIVAHELGHNLGMNHDDGRDCSCGAKSCIMNSGASGSRNFSSCSAEDFEKLTLNKGGNCLLNIPKPDEAYSAPSCGNKLVDAGEECDCGTPKECELDPCCEGSTCKLKSFAECAYGDCCKDCRFLPGGTLCRGKTSECDVPEYCNGSSQFCQPDVFIQNGYPCQNNKAYCYNGMCQYYDAQCQVIFGSKAKAAPKDCFIEVNSKGDRFGNCGFSGNEYKKCATGNALCGKLQCENVQEIPVFGIVPAIIQTPSRGTKCWGVDFQLGSDVPDPGMVNEGTKCGAGKICRNFQCVDASVLNYDCDVQKKCHGHGVCNSNKNCHCENGWAPPNCETKGYGGSVDSGPTYNEMNTALRDGLLVFFFLIVPLIVCAIFIFIKRDQLWRSYFRKKRSQTYESDGKNQANPSRQPGSVPRHVSPVTPPREVPIYANRFAVPTYAAKQPQQFPSRPPPPQPKVSSQGNLIPARPAPAPPLYSSLT
Predictions
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q13443 As Substrate
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| K85 | Ubiquitination | Uniprot | |
| K184 | Acetylation | Uniprot | |
| K188 | Acetylation | Uniprot | |
| Y213 | Phosphorylation | Uniprot | |
| Y250 | Phosphorylation | Uniprot | |
| S364 | Phosphorylation | Uniprot | |
| S377 | Phosphorylation | Uniprot | |
| S379 | Phosphorylation | Uniprot | |
| K392 | Ubiquitination | Uniprot | |
| K397 | Ubiquitination | Uniprot | |
| K450 | Ubiquitination | Uniprot | |
| S451 | Phosphorylation | Uniprot | |
| Y457 | Phosphorylation | Uniprot | |
| K533 | Acetylation | Uniprot | |
| K546 | Ubiquitination | Uniprot | |
| K561 | Ubiquitination | Uniprot | |
| T735 | Phosphorylation | Uniprot | |
| Y736 | Phosphorylation | Uniprot | |
| S738 | Phosphorylation | Uniprot | |
| K741 | Ubiquitination | Uniprot | |
| S747 | Phosphorylation | Uniprot | |
| S752 | Phosphorylation | Uniprot | |
| S758 | O-Glycosylation | Uniprot | |
| S758 | Phosphorylation | Uniprot | |
| T761 | O-Glycosylation | Uniprot | |
| T761 | Phosphorylation | Uniprot | |
| Y769 | Phosphorylation | Uniprot | |
| R772 | Methylation | Uniprot | |
| T777 | O-Glycosylation | Uniprot | |
| T777 | Phosphorylation | Uniprot | |
| Y778 | Phosphorylation | Uniprot | |
| K781 | Ubiquitination | Uniprot | |
| K796 | Ubiquitination | Uniprot | |
| S798 | Phosphorylation | Uniprot | |
| S799 | Phosphorylation | Uniprot | |
| Y815 | Phosphorylation | Uniprot | |
| S816 | Phosphorylation | Uniprot | |
| S817 | Phosphorylation | Uniprot | |
| T819 | Phosphorylation | Uniprot |
Research Backgrounds
Cleaves and releases a number of molecules with important roles in tumorigenesis and angiogenesis, such as TEK, KDR, EPHB4, CD40, VCAM1 and CDH5. May mediate cell-cell, cell-matrix interactions and regulate the motility of cells via interactions with integrins.
May act as alpha-secretase for amyloid precursor protein (APP).
Proteolytically cleaved in the trans-Golgi network before it reaches the plasma membrane to generate a mature protein. The removal of the pro-domain occurs via cleavage at two different sites. Processed most likely by a pro-protein convertase such as furin, at the boundary between the pro-domain and the catalytic domain. An additional upstream cleavage pro-protein convertase site (Arg-56/Glu-57) has an important role in the activation of ADAM9.
Phosphorylation is induced in vitro by phorbol-12-myristate-13-acetate (PMA).
Cell membrane>Single-pass type I membrane protein.
Secreted.
Widely expressed. Expressed in chondrocytes. Isoform 2 is highly expressed in liver and heart.
Interacts with SH3GL2 and SNX9 through its cytoplasmic tail. Interacts with ITGA6.
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