Phospho-PRPS1 (Ser180) Antibody - #AF8611
| Product: | Phospho-PRPS1 (Ser180) Antibody |
| Catalog: | AF8611 |
| Description: | Rabbit polyclonal antibody to Phospho-PRPS1 (Ser180) |
| Application: | WB IHC |
| Reactivity: | Human, Mouse, Rat |
| Prediction: | Pig, Bovine, Horse, Sheep, Rabbit, Dog, Chicken, Xenopus |
| Mol.Wt.: | 34 KD; 35kD(Calculated). |
| Uniprot: | P60891 |
| RRID: | AB_2843462 |
Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# AF8611, RRID:AB_2843462.
Fold/Unfold
ARTS; CMTX5; Deafness 2 perceptive congenital; Deafness X linked 2 perceptive congenital; DFN2; DFNX1; EC 2.7.6.1; KIAA0967; Phosphoribosyl pyrophosphate synthase I; Phosphoribosyl pyrophosphate synthetase I; PPRibP; Prps1; PRPS1_HUMAN; PRS I; PRS-I; PRSI; Ribose phosphate pyrophosphokinase I; Ribose-phosphate pyrophosphokinase 1;
Immunogens
- P60891 PRPS1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MPNIKIFSGSSHQDLSQKIADRLGLELGKVVTKKFSNQETCVEIGESVRGEDVYIVQSGCGEINDNLMELLIMINACKIASASRVTAVIPCFPYARQDKKDKSRAPISAKLVANMLSVAGADHIITMDLHASQIQGFFDIPVDNLYAEPAVLKWIRENISEWRNCTIVSPDAGGAKRVTSIADRLNVDFALIHKERKKANEVDRMVLVGDVKDRVAILVDDMADTCGTICHAADKLLSAGATRVYAILTHGIFSGPAISRINNACFEAVVVTNTIPQEDKMKHCSKIQVIDISMILAEAIRRTHNGESVSYLFSHVPL
Predictions
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - P60891 As Substrate
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| K5 | Ubiquitination | Uniprot | |
| K18 | Ubiquitination | Uniprot | |
| R22 | Methylation | Uniprot | |
| K29 | Ubiquitination | Uniprot | |
| S36 | Phosphorylation | Uniprot | |
| S103 | Phosphorylation | Uniprot | |
| Y146 | Phosphorylation | Uniprot | |
| R156 | Methylation | Uniprot | |
| K176 | Acetylation | Uniprot | |
| K176 | Ubiquitination | Uniprot | |
| S180 | Phosphorylation | Uniprot | |
| R184 | Methylation | Uniprot | |
| K194 | Acetylation | Uniprot | |
| K194 | Ubiquitination | Uniprot | |
| R204 | Methylation | Uniprot | |
| K212 | Acetylation | Uniprot | |
| K212 | Ubiquitination | Uniprot | |
| T225 | Phosphorylation | Uniprot | |
| T228 | Phosphorylation | Uniprot | |
| K235 | Ubiquitination | Uniprot | |
| S238 | Phosphorylation | Uniprot | |
| T242 | Phosphorylation | Uniprot | |
| Y245 | Phosphorylation | Uniprot | |
| K280 | Ubiquitination | Uniprot | |
| S308 | Phosphorylation | Uniprot | |
| S310 | Phosphorylation | Uniprot | |
| Y311 | Phosphorylation | Uniprot |
Research Backgrounds
Catalyzes the synthesis of phosphoribosylpyrophosphate (PRPP) that is essential for nucleotide synthesis.
Homodimer. The active form is probably a hexamer composed of 3 homodimers.
Belongs to the ribose-phosphate pyrophosphokinase family.
Research Fields
· Metabolism > Carbohydrate metabolism > Pentose phosphate pathway.
· Metabolism > Nucleotide metabolism > Purine metabolism.
· Metabolism > Global and overview maps > Metabolic pathways.
· Metabolism > Global and overview maps > Carbon metabolism.
· Metabolism > Global and overview maps > Biosynthesis of amino acids.
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