COX7a2/3 Antibody - #AF9048
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Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# AF9048, RRID:AB_2843239.
Fold/Unfold
COX7A3; COX7AL2; COX7S/A2; Cytochrome c oxidase subunit 7A3, mitochondrial; Cytochrome c oxidase subunit VIIa 3; COX7A2; COX7AL; COX7AL1; COXVIIa L; COXVIIAL; CX7A2_HUMAN; Cytochrome c oxidase polypeptide 7A2 mitochondrial; Cytochrome c oxidase polypeptide VIIa liver/heart; Cytochrome c oxidase subunit 7A2; Cytochrome c oxidase subunit 7A2 mitochondrial; Cytochrome c oxidase subunit VIIa polypeptide 2; Cytochrome c oxidase subunit VIIa-L; Cytochrome c oxidase subunit VIIa-liver/heart; Cytochrome c oxidase subunit VIIaL; Hepatic cytochrome c oxidase chain VIIa; MGC118950; MGC118951; MGC118952; MGC126875; MGC126877; mitochondrial; VIIAL;
Immunogens
- O60397 COX7S_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MLWNLLALHQIGQRTISTASHRHFKNKVPEKQKLFQEDDGIPLYLKGGIADALLHRATMILTVGGTAYAIYQLAVASFPNKGVTSIIPAITWFTFIQLSMDQKSDK
- P14406 CX7A2_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MLRNLLALRQIGQRTISTASRRHFKNKVPEKQKLFQEDDEIPLYLKGGVADALLYRATMILTVGGTAYAIYELAVASFPKKQE
PTMs - O60397/P14406 As Substrate
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| M1 | Acetylation | Uniprot | |
| K33 | Acetylation | Uniprot | |
| K33 | Ubiquitination | Uniprot | |
| Y44 | Phosphorylation | Uniprot | |
| K46 | Ubiquitination | Uniprot | |
| Y55 | Phosphorylation | Uniprot | |
| Y71 | Phosphorylation | Uniprot |
Research Backgrounds
Mitochondrion inner membrane.
Belongs to the cytochrome c oxidase VIIa family.
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
Mitochondrion inner membrane>Single-pass membrane protein.
Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits. The complex is composed of a catalytic core of 3 subunits MT-CO1, MT-CO2 and MT-CO3, encoded in the mitochondrial DNA, and 11 supernumerary subunits COX4I1 (or COX4I2), COX5A, COX5B, COX6A1 (or COX6A2), COX6B1 (or COX6B2), COX6C, COX7A2 (or COX7A1), COX7B, COX7C, COX8A and NDUFA4, which are encoded in the nuclear genome. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)). Interacts with PET100.
Belongs to the cytochrome c oxidase VIIa family.
Research Fields
· Human Diseases > Endocrine and metabolic diseases > Non-alcoholic fatty liver disease (NAFLD).
· Human Diseases > Neurodegenerative diseases > Alzheimer's disease.
· Human Diseases > Neurodegenerative diseases > Parkinson's disease.
· Human Diseases > Neurodegenerative diseases > Huntington's disease.
· Metabolism > Energy metabolism > Oxidative phosphorylation.
· Organismal Systems > Circulatory system > Cardiac muscle contraction. (View pathway)
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