TRAK2 Antibody - #DF9963

(6)  
Product: TRAK2 Antibody
Catalog: DF9963
Description: Rabbit polyclonal antibody to TRAK2
Application: WB IHC IF/ICC
Reactivity: Human
Prediction: Pig, Horse, Dog
Mol.Wt.: 101 kDa; 101kD(Calculated).
Uniprot: O60296
RRID: AB_2843157

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Related Downloads
MSDS
Data Sheet
COA
Protocols
WB Handbook
IHC Protocol
IF/ICC Protocol

Product Info

Source:
Rabbit
Application:
IF/ICC 1:100-1:500, IHC 1:50-1:200, WB 1:1000-3000
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

Reactivity:
Human
Prediction:
Pig(88%), Horse(88%), Dog(88%)
Clonality:
Polyclonal
Specificity:
TRAK2 Antibody detects endogenous levels of total TRAK2.
RRID:
AB_2843157
Cite Format: Affinity Biosciences Cat# DF9963, RRID:AB_2843157.
Conjugate:
Unconjugated.
Purification:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
Storage:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
Alias:

Fold/Unfold

ALS2CR 3; Amyotrophic lateral sclerosis 2 (juvenile) chromosome region candidate 3; Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 3 protein; CALS C; GRIF 1; GRIF1; KIAA0549; OIP98; Trafficking kinesin-binding protein 2; Trafficking protein kinesin binding 2; Trak2; TRAK2_HUMAN;

Immunogens

Immunogen:
Uniprot:

O60296(TRAK2_HUMAN) >>Visit HPA database.

Gene(ID):
TRAK2(66008)
Expression:
O60296 TRAK2_HUMAN:

Widely expressed, with highest expression in heart.

Sequence:
MSQSQNAIFTSPTGEENLMNSNHRDSESITDVCSNEDLPEVELVSLLEEQLPQYRLKVDTLFLYENQDWTQSPHQRQHASDALSPVLAEETFRYMILGTDRVEQMTKTYNDIDMVTHLLAERDRDLELAARIGQALLKRNHVLSEQNESLEEQLGQAFDQVNQLQHELCKKDELLRIVSIASEESETDSSCSTPLRFNESFSLSQGLLQLEMLQEKLKELEEENMALRSKACHIKTETVTYEEKEQQLVSDCVKELRETNAQMSRMTEELSGKSDELIRYQEELSSLLSQIVDLQHKLKEHVIEKEELKLHLQASKDAQRQLTMELHELQDRNMECLGMLHESQEEIKELRSRSGPTAHLYFSQSYGAFTGESLAAEIEGTMRKKLSLDEESSLFKQKAQQKRVFDTVRIANDTRGRSISFPALLPIPGSNRSSVIMTAKPFESGLQQTEDKSLLNQGSSSEEVAGSSQKMGQPGPSGDSDLATALHRLSLRRQNYLSEKQFFAEEWQRKIQVLADQKEGVSGCVTPTESLASLCTTQSEITDLSSASCLRGFMPEKLQIVKPLEGSQTLYHWQQLAQPNLGTILDPRPGVITKGFTQLPGDAIYHISDLEEDEEEGITFQVQQPLEVEEKLSTSKPVTGIFLPPITSAGGPVTVATANPGKCLSCTNSTFTFTTCRILHPSDITQVTPSSGFPSLSCGSSGSSSSNTAVNSPALSYRLSIGESITNRRDSTTTFSSTMSLAKLLQERGISAKVYHSPISENPLQPLPKSLAIPSTPPNSPSHSPCPSPLPFEPRVHLSENFLASRPAETFLQEMYGLRPSRNPPDVGQLKMNLVDRLKRLGIARVVKNPGAQENGRCQEAEIGPQKPDSAVYLNSGSSLLGGLRRNQSLPVIMGSFAAPVCTSSPKMGVLKED

Predictions

Predictions:

Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.

Species
Results
Score
Pig
88
Horse
88
Dog
88
Bovine
75
Sheep
75
Zebrafish
75
Rabbit
75
Xenopus
63
Chicken
63
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

PTMs - O60296 As Substrate

Site PTM Type Enzyme
S84 Phosphorylation
K107 Ubiquitination
K138 Ubiquitination
K254 Ubiquitination
K273 Ubiquitination
Y280 Phosphorylation
S285 Phosphorylation
S289 Phosphorylation
K299 Acetylation
K299 Ubiquitination
K316 Ubiquitination
K385 Ubiquitination
S387 Phosphorylation
K396 Ubiquitination
S420 Phosphorylation
S430 Phosphorylation
S498 Phosphorylation
K510 Ubiquitination
S567 Phosphorylation
T674 Phosphorylation
T675 Phosphorylation
T688 Phosphorylation
S691 Phosphorylation
T708 Phosphorylation
S731 Phosphorylation
S751 Phosphorylation
S760 Phosphorylation
S775 Phosphorylation
T776 Phosphorylation
S780 Phosphorylation
S782 Phosphorylation
S784 Phosphorylation
S788 Phosphorylation
T810 Phosphorylation
Y816 Phosphorylation
K831 Methylation
S889 Phosphorylation

Research Backgrounds

Function:

May regulate endosome-to-lysosome trafficking of membrane cargo, including EGFR.

PTMs:

O-glycosylated.

Subcellular Location:

Cytoplasm. Early endosome. Mitochondrion.
Note: Colocalizes with MGARP at the mitochondria. Translocates from the cytoplasm to the mitochondria in a MGARP-dependent manner (By similarity).

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
Tissue Specificity:

Widely expressed, with highest expression in heart.

Subunit Structure:

Interacts with GABA-A receptor and O-GlcNAc transferase. Interacts with HGS (By similarity). Interacts with RHOT1/Miro-1 and RHOT2/Miro-2.

Family&Domains:

Belongs to the milton family.

Research Fields

· Metabolism > Global and overview maps > Metabolic pathways.

· Organismal Systems > Nervous system > GABAergic synapse.

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