FXYD2 Antibody - #DF9941

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Product: FXYD2 Antibody
Catalog: DF9941
Description: Rabbit polyclonal antibody to FXYD2
Application: WB IHC
Reactivity: Human, Mouse
Prediction: Chicken
Mol.Wt.: 7 kDa; 7kD(Calculated).
Uniprot: P54710
RRID: AB_2843135

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Related Downloads
MS Report
HPLC Report
MSDS
Data Sheet
COA
Protocols
WB Handbook
IHC Protocol
IF/ICC Protocol

Product Info

Source:
Rabbit
Application:
WB 1:1000-3000, IHC 1:50-1:200
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

Reactivity:
Human,Mouse
Prediction:
Chicken(88%)
Clonality:
Polyclonal
Specificity:
FXYD2 Antibody detects endogenous levels of total FXYD2.
RRID:
AB_2843135
Cite Format: Affinity Biosciences Cat# DF9941, RRID:AB_2843135.
Conjugate:
Unconjugated.
Purification:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
Storage:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
Alias:

Fold/Unfold

Sodium potassium ATPase, gamma-1 polypeptide; ATP 1C; ATP1 C; ATP1 G1; ATP1C; ATP1G 1; ATP1G1; ATPase, Na+/K+ transporting, gamma 1 polypeptide; FXYD 2; FXYD domain containing ion transport regulator 2; Gamma subunit of sodium potassium ATPase; GNAKATP; HOMG 2; HOMG2; Hypomagnesemia 2, renal; Na(+)/K(+) ATPase subunit gamma; Sodium potassium ATPase, gamma polypeptide; Sodium pump gamma chain; Sodium/potassium-transporting ATPase gamma chain; sodium/potassium-transporting ATPase subunit gamma;

Immunogens

Immunogen:
Uniprot:

P54710(ATNG_HUMAN) >>Visit HPA database.

Gene(ID):
FXYD2(486)
Expression:
P54710 ATNG_HUMAN:

Expressed in the distal convoluted tubule in the kidney. Found on basolateral membranes of nephron epithelial cells.

Sequence:
MTGLSMDGGGSPKGDVDPFYYDYETVRNGGLIFAGLAFIVGLLILLSRRFRCGGNKKRRQINEDEP

Predictions

Predictions:

Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.

Species
Results
Score
Chicken
88
Dog
67
Pig
0
Horse
0
Bovine
0
Sheep
0
Xenopus
0
Zebrafish
0
Rabbit
0
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

PTMs - P54710 As Substrate

Site PTM Type Enzyme

Research Backgrounds

Function:

May be involved in forming the receptor site for cardiac glycoside binding or may modulate the transport function of the sodium ATPase.

Subcellular Location:

Membrane>Single-pass type III membrane protein.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
Tissue Specificity:

Expressed in the distal convoluted tubule in the kidney. Found on basolateral membranes of nephron epithelial cells.

Subunit Structure:

Regulatory subunit of the sodium/potassium-transporting ATPase which is composed of a catalytic alpha subunit, an auxiliary non-catalytic beta subunit and an additional regulatory subunit.

Family&Domains:

Belongs to the FXYD family.

Research Fields

· Environmental Information Processing > Signal transduction > cGMP-PKG signaling pathway.   (View pathway)

· Environmental Information Processing > Signal transduction > cAMP signaling pathway.   (View pathway)

· Organismal Systems > Circulatory system > Cardiac muscle contraction.   (View pathway)

· Organismal Systems > Circulatory system > Adrenergic signaling in cardiomyocytes.   (View pathway)

· Organismal Systems > Endocrine system > Insulin secretion.   (View pathway)

· Organismal Systems > Endocrine system > Thyroid hormone synthesis.

· Organismal Systems > Endocrine system > Thyroid hormone signaling pathway.   (View pathway)

· Organismal Systems > Excretory system > Aldosterone-regulated sodium reabsorption.

· Organismal Systems > Excretory system > Endocrine and other factor-regulated calcium reabsorption.

· Organismal Systems > Excretory system > Proximal tubule bicarbonate reclamation.

· Organismal Systems > Digestive system > Salivary secretion.

· Organismal Systems > Digestive system > Pancreatic secretion.

· Organismal Systems > Digestive system > Carbohydrate digestion and absorption.

· Organismal Systems > Digestive system > Protein digestion and absorption.

· Organismal Systems > Digestive system > Mineral absorption.

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