SerpinB6 Antibody - #DF9895
| Product: | SerpinB6 Antibody |
| Catalog: | DF9895 |
| Description: | Rabbit polyclonal antibody to SerpinB6 |
| Application: | WB IHC |
| Reactivity: | Human, Mouse, Rat |
| Prediction: | Dog |
| Mol.Wt.: | 43 kDa; 43kD(Calculated). |
| Uniprot: | P35237 |
| RRID: | AB_2843089 |
Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# DF9895, RRID:AB_2843089.
Fold/Unfold
CAP; Cytoplasmic antiproteinase; Peptidase inhibitor 6; PI-6; PI6; Placental thrombin inhibitor; Protease inhibitor 6 (placental thrombin inhibitor); PTI; Serpin B6; SERPINB6; SPB6_HUMAN;
Immunogens
Expressed in keratinocytes (at protein level). Highest levels in skeletal muscle. Also found in placenta, cardiac muscle, lung, liver, kidney and pancreas. Expressed in the inner ear hair cells. Expressed abundantly by normal mast cells in different tissues and by mast cells in mastocytoma lesions.
- P35237 SPB6_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MDVLAEANGTFALNLLKTLGKDNSKNVFFSPMSMSCALAMVYMGAKGNTAAQMAQILSFNKSGGGGDIHQGFQSLLTEVNKTGTQYLLRMANRLFGEKSCDFLSSFRDSCQKFYQAEMEELDFISAVEKSRKHINTWVAEKTEGKIAELLSPGSVDPLTRLVLVNAVYFRGNWDEQFDKENTEERLFKVSKNEEKPVQMMFKQSTFKKTYIGEIFTQILVLPYVGKELNMIIMLPDETTDLRTVEKELTYEKFVEWTRLDMMDEEEVEVSLPRFKLEESYDMESVLRNLGMTDAFELGKADFSGMSQTDLSLSKVVHKSFVEVNEEGTEAAAATAAIMMMRCARFVPRFCADHPFLFFIQHSKTNGILFCGRFSSP
Predictions
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - P35237 As Substrate
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| M1 | Acetylation | Uniprot | |
| Y42 | Phosphorylation | Uniprot | |
| T49 | Phosphorylation | Uniprot | |
| S58 | Phosphorylation | Uniprot | |
| K61 | Ubiquitination | Uniprot | |
| S62 | Phosphorylation | Uniprot | |
| R89 | Methylation | Uniprot | |
| R93 | Methylation | Uniprot | |
| S99 | Phosphorylation | Uniprot | |
| K129 | Ubiquitination | Uniprot | |
| K132 | Ubiquitination | Uniprot | |
| K141 | Ubiquitination | Uniprot | |
| S151 | Phosphorylation | Uniprot | |
| Y168 | Phosphorylation | Uniprot | |
| K179 | Ubiquitination | Uniprot | |
| T182 | Phosphorylation | Uniprot | |
| K208 | Ubiquitination | Uniprot | |
| K246 | Ubiquitination | Uniprot | |
| Y250 | Phosphorylation | Uniprot | |
| K252 | Acetylation | Uniprot | |
| K252 | Ubiquitination | Uniprot | |
| S306 | Phosphorylation | Uniprot | |
| K314 | Ubiquitination | Uniprot |
Research Backgrounds
May be involved in the regulation of serine proteinases present in the brain or extravasated from the blood (By similarity). Inhibitor of cathepsin G, kallikrein-8 and thrombin. May play an important role in the inner ear in the protection against leakage of lysosomal content during stress and loss of this protection results in cell death and sensorineural hearing loss.
Cytoplasm.
Expressed in keratinocytes (at protein level). Highest levels in skeletal muscle. Also found in placenta, cardiac muscle, lung, liver, kidney and pancreas. Expressed in the inner ear hair cells. Expressed abundantly by normal mast cells in different tissues and by mast cells in mastocytoma lesions.
Forms a complex with the monomeric form of beta-tryptase.
Belongs to the serpin family. Ov-serpin subfamily.
Research Fields
· Human Diseases > Infectious diseases: Parasitic > Amoebiasis.
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