SEPT11 Antibody - #DF9880

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Product: SEPT11 Antibody
Catalog: DF9880
Description: Rabbit polyclonal antibody to SEPT11
Application: WB IHC
Reactivity: Human, Mouse, Rat
Prediction: Pig, Bovine, Horse, Sheep, Rabbit, Dog, Chicken
Mol.Wt.: 49 kDa; 49kD(Calculated).
Uniprot: Q9NVA2
RRID: AB_2843074

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 100ul $280 In stock
 200ul $350 In stock

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Related Downloads
MS Report
HPLC Report
MSDS
Data Sheet
COA
Protocols
WB Handbook
IHC Protocol
IF/ICC Protocol

Product Info

Source:
Rabbit
Application:
WB 1:1000-3000, IHC 1:50-1:200
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

Reactivity:
Human,Mouse,Rat
Prediction:
Pig(100%), Bovine(100%), Horse(100%), Sheep(100%), Rabbit(100%), Dog(100%), Chicken(100%)
Clonality:
Polyclonal
Specificity:
SEPT11 Antibody detects endogenous levels of total SEPT11.
RRID:
AB_2843074
Cite Format: Affinity Biosciences Cat# DF9880, RRID:AB_2843074.
Conjugate:
Unconjugated.
Purification:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
Storage:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
Alias:

Fold/Unfold

SEP11_HUMAN; SEPT 11; Sept11; Septin-11; Septin11;

Immunogens

Immunogen:
Uniprot:

Q9NVA2(SEP11_HUMAN) >>Visit HPA database.

Gene(ID):
SEPT11(55752)
Expression:
Q9NVA2 SEP11_HUMAN:

Widely expressed, except in leukocytes.

Sequence:
MAVAVGRPSNEELRNLSLSGHVGFDSLPDQLVNKSTSQGFCFNILCVGETGIGKSTLMDTLFNTKFESDPATHNEPGVRLKARSYELQESNVRLKLTIVDTVGFGDQINKDDSYKPIVEYIDAQFEAYLQEELKIKRSLFNYHDTRIHACLYFIAPTGHSLKSLDLVTMKKLDSKVNIIPIIAKADTIAKNELHKFKSKIMSELVSNGVQIYQFPTDEETVAEINATMSVHLPFAVVGSTEEVKIGNKMAKARQYPWGVVQVENENHCDFVKLREMLIRVNMEDLREQTHTRHYELYRRCKLEEMGFKDTDPDSKPFSLQETYEAKRNEFLGELQKKEEEMRQMFVMRVKEKEAELKEAEKELHEKFDLLKRTHQEEKKKVEDKKKELEEEVNNFQKKKAAAQLLQSQAQQSGAQQTKKDKDKKNASFT

Predictions

Predictions:

Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.

Species
Results
Score
Pig
100
Horse
100
Bovine
100
Sheep
100
Dog
100
Chicken
100
Rabbit
100
Xenopus
73
Zebrafish
0
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

PTMs - Q9NVA2 As Substrate

Site PTM Type Enzyme
A2 Acetylation
S9 Phosphorylation
S17 Phosphorylation
T64 Phosphorylation
K65 Ubiquitination
S84 Phosphorylation
Y85 Phosphorylation
S90 Phosphorylation
T145 Phosphorylation
K170 Ubiquitination
K175 Ubiquitination
K184 Ubiquitination
Y294 Phosphorylation
Y297 Phosphorylation
K301 Ubiquitination
K308 Ubiquitination
T310 Phosphorylation
S314 Phosphorylation
K315 Ubiquitination
S318 Phosphorylation
Y323 Phosphorylation
K326 Ubiquitination
K336 Ubiquitination
K337 Ubiquitination
K357 Ubiquitination
K361 Acetylation
K366 Ubiquitination
K378 Acetylation
K399 Ubiquitination
S407 Phosphorylation
S412 Phosphorylation
K418 Ubiquitination

Research Backgrounds

Function:

Filament-forming cytoskeletal GTPase. May play a role in cytokinesis (Potential). May play a role in the cytoarchitecture of neurons, including dendritic arborization and dendritic spines, and in GABAergic synaptic connectivity (By similarity). During Listeria monocytogenes infection, not required for the bacterial entry process, but restricts its efficacy.

Subcellular Location:

Cytoplasm>Cytoskeleton. Cell junction>Synapse. Cell projection>Dendritic spine. Cell projection>Axon.
Note: Partly colocalizes with stress fibers and microtubules. During bacterial infection, displays a collar shape structure next to actin at the pole of invading bacteria.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
Tissue Specificity:

Widely expressed, except in leukocytes.

Subunit Structure:

Septins polymerize into heterooligomeric protein complexes that form filaments, and can associate with cellular membranes, actin filaments and microtubules. Forms homooligomers. GTPase activity is required for filament formation. Interacts with SEPTIN7, SEPTIN9 and SEPTIN12.

Family&Domains:

Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.

Research Fields

· Human Diseases > Infectious diseases: Bacterial > Bacterial invasion of epithelial cells.

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