PPP1R3D Antibody - #DF9780
| Product: | PPP1R3D Antibody |
| Catalog: | DF9780 |
| Description: | Rabbit polyclonal antibody to PPP1R3D |
| Application: | WB IHC IF/ICC |
| Reactivity: | Human, Mouse, Rat |
| Prediction: | Bovine, Sheep, Dog, Chicken |
| Mol.Wt.: | 33 kDa; 33kD(Calculated). |
| Uniprot: | O95685 |
| RRID: | AB_2842975 |
Related Downloads
Protocols
Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# DF9780, RRID:AB_2842975.
Fold/Unfold
PP1 subunit R6; PPP1R3D; PPP1R6; PPR3D_HUMAN; Protein phosphatase 1 regulatory subunit 3D; Protein phosphatase 1 regulatory subunit 6; Protein phosphatase 1-binding subunit R6;
Immunogens
- O95685 PPR3D_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MSRGPSSAVLPSALGSRKLGPRSLSCLSDLDGGVALEPRACRPPGSPGRAPPPTPAPSGCDPRLRPIILRRARSLPSSPERRQKAAGAPGAACRPGCSQKLRVRFADALGLELAQVKVFNAGDDPSVPLHVLSRLAINSDLCCSSQDLEFTLHCLVPDFPPPVEAADFGERLQRQLVCLERVTCSDLGISGTVRVCNVAFEKQVAVRYTFSGWRSTHEAVARWRGPAGPEGTEDVFTFGFPVPPFLLELGSRVHFAVRYQVAGAEYWDNNDHRDYSLTCRNHALHMPRGECEESWIHFI
Predictions
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - O95685 As Substrate
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| R3 | Methylation | Uniprot | |
| S6 | Phosphorylation | Uniprot | |
| S7 | Phosphorylation | Uniprot | |
| S16 | Phosphorylation | Uniprot | |
| S23 | Phosphorylation | Uniprot | |
| S25 | Phosphorylation | Uniprot | |
| S28 | Phosphorylation | Uniprot | |
| S46 | Phosphorylation | Uniprot | |
| T54 | Phosphorylation | Uniprot | |
| S74 | Phosphorylation | Uniprot | |
| S77 | Phosphorylation | Uniprot | |
| S78 | Phosphorylation | Uniprot | |
| S98 | Phosphorylation | Uniprot | |
| K100 | Ubiquitination | Uniprot | |
| S133 | Phosphorylation | Uniprot |
Research Backgrounds
Seems to act as a glycogen-targeting subunit for PP1. PP1 is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis.
Expressed in all tissues tested. High expression in skeletal muscle and heart.
Interacts with PPP1CC catalytic subunit of PP1, and associates with glycogen. Interacts with EPM2A; in the presence of NHLC1/malin the interaction leads to PPP1R3D ubiquitination and autophagic degradation.
The CBM21 domain is known to be involved in the localization to glycogen and is characteristic of some regulatory subunit of phosphatase complexes.
Research Fields
· Human Diseases > Endocrine and metabolic diseases > Insulin resistance.
· Organismal Systems > Endocrine system > Insulin signaling pathway. (View pathway)
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