NLGN1 Antibody - #DF9690
| Product: | NLGN1 Antibody |
| Catalog: | DF9690 |
| Description: | Rabbit polyclonal antibody to NLGN1 |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Prediction: | Pig, Bovine, Horse, Rabbit, Chicken |
| Mol.Wt.: | 94 kDa; 96kD(Calculated). |
| Uniprot: | Q8N2Q7 |
| RRID: | AB_2842886 |
Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# DF9690, RRID:AB_2842886.
Fold/Unfold
NLG 1; KIAA1070; MGC45115; Neuroligin-1; NL1; NLG1; Nlgn1; NLGN1_HUMAN;
Immunogens
Expressed in the blood vessel walls (at protein level). Detected in brain, and at lower levels in pancreas islet beta cells.
- Q8N2Q7 NLGN1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MALPRCTWPNYVWRAVMACLVHRGLGAPLTLCMLGCLLQAGHVLSQKLDDVDPLVATNFGKIRGIKKELNNEILGPVIQFLGVPYAAPPTGERRFQPPEPPSPWSDIRNATQFAPVCPQNIIDGRLPEVMLPVWFTNNLDVVSSYVQDQSEDCLYLNIYVPTEDVKRISKECARKPGKKICRKGGPLTKKQTDDLGDNDGAEDEDIRDSGGPKPVMVYIHGGSYMEGTGNLYDGSVLASYGNVIVITVNYRLGVLGFLSTGDQAAKGNYGLLDLIQALRWTSENIGFFGGDPLRITVFGSGAGGSCVNLLTLSHYSEGNRWSNSTKGLFQRAIAQSGTALSSWAVSFQPAKYARMLATKVGCNVSDTVELVECLQKKPYKELVDQDIQPARYHIAFGPVIDGDVIPDDPQILMEQGEFLNYDIMLGVNQGEGLKFVENIVDSDDGISASDFDFAVSNFVDNLYGYPEGKDVLRETIKFMYTDWADRHNPETRRKTLLALFTDHQWVAPAVATADLHSNFGSPTYFYAFYHHCQTDQVPAWADAAHGDEVPYVLGIPMIGPTELFPCNFSKNDVMLSAVVMTYWTNFAKTGDPNQPVPQDTKFIHTKPNRFEEVAWTRYSQKDQLYLHIGLKPRVKEHYRANKVNLWLELVPHLHNLNDISQYTSTTTKVPSTDITFRPTRKNSVPVTSAFPTAKQDDPKQQPSPFSVDQRDYSTELSVTIAVGASLLFLNILAFAALYYKKDKRRHDVHRRCSPQRTTTNDLTHAQEEEIMSLQMKHTDLDHECESIHPHEVVLRTACPPDYTLAMRRSPDDVPLMTPNTITMIPNTIPGIQPLHTFNTFTGGQNNTLPHPHPHPHSHSTTRV
Predictions
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q8N2Q7 As Substrate
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S102 | Phosphorylation | Uniprot | |
| S105 | Phosphorylation | Uniprot | |
| K583 | Ubiquitination | Uniprot | |
| S660 | O-Glycosylation | Uniprot | |
| T664 | O-Glycosylation | Uniprot | |
| S665 | O-Glycosylation | Uniprot | |
| T669 | O-Glycosylation | Uniprot | |
| Y689 | Phosphorylation | Uniprot | |
| Y716 | Phosphorylation | Uniprot |
Research Backgrounds
Cell surface protein involved in cell-cell-interactions via its interactions with neurexin family members. Plays a role in synapse function and synaptic signal transmission, and probably mediates its effects by recruiting and clustering other synaptic proteins. May promote the initial formation of synapses, but is not essential for this. In vitro, triggers the de novo formation of presynaptic structures. May be involved in specification of excitatory synapses. Required to maintain wakefulness quality and normal synchrony of cerebral cortex activity during wakefulness and sleep.
Cell membrane>Single-pass type I membrane protein. Cell junction>Synapse>Postsynaptic density. Cell junction>Synapse>Synaptic cleft. Cell junction>Synapse>Synaptic cell membrane.
Note: Enriched in synaptic plasma membranes and clustered in synaptic clefts and postsynaptic densities. Colocalized with DLG4/PSD-95 and GRIN1/NMDAR1.
Expressed in the blood vessel walls (at protein level). Detected in brain, and at lower levels in pancreas islet beta cells.
Interacts with NRXN1, NRXN2 and NRXN3. Interacts with NLGN3. Interacts with AIP1 and PDZRN3 (By similarity). Interacts (via its C-terminus) with DLG4/PSD-95 (via PDZ domain 3). Interacts with GOPC.
Belongs to the type-B carboxylesterase/lipase family.
Research Fields
· Environmental Information Processing > Signaling molecules and interaction > Cell adhesion molecules (CAMs). (View pathway)
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