NDUFS8 Antibody - #DF9672
| Product: | NDUFS8 Antibody |
| Catalog: | DF9672 |
| Description: | Rabbit polyclonal antibody to NDUFS8 |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Prediction: | Pig, Bovine, Horse, Sheep, Dog, Chicken, Xenopus |
| Mol.Wt.: | 24 kDa; 24kD(Calculated). |
| Uniprot: | O00217 |
| RRID: | AB_2842868 |
Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# DF9672, RRID:AB_2842868.
Fold/Unfold
CI 23kD; CI-23kD; Complex I 23kD; Complex I-23kD; EC 1.6.5.3; EC 1.6.99.3; Human mitochondrial NADH dehydrogenase ubiquinone Fe S protein 8; NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial; NADH ubiquinone oxidoreductase 23 kDa subunit; NADH-ubiquinone oxidoreductase 23 kDa subunit; NDUFS8; NDUS8_HUMAN; TYKY; TYKY subunit; Ubiquinoneiron sulfur protein 8, mitochondrial precursor;
Immunogens
- O00217 NDUS8_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MRCLTTPMLLRALAQAARAGPPGGRSLHSSAVAATYKYVNMQDPEMDMKSVTDRAARTLLWTELFRGLGMTLSYLFREPATINYPFEKGPLSPRFRGEHALRRYPSGEERCIACKLCEAICPAQAITIEAEPRADGSRRTTRYDIDMTKCIYCGFCQEACPVDAIVEGPNFEFSTETHEELLYNKEKLLNNGDKWEAEIAANIQADYLYR
Predictions
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - O00217 As Substrate
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| Y38 | Phosphorylation | Uniprot | |
| K49 | Ubiquitination | Uniprot | |
| T52 | Phosphorylation | Uniprot | |
| S73 | Phosphorylation | Uniprot | |
| Y74 | Phosphorylation | Uniprot | |
| K88 | Ubiquitination | Uniprot | |
| R96 | Methylation | Uniprot | |
| R133 | Methylation | Uniprot |
Research Backgrounds
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity). May donate electrons to ubiquinone.
Mitochondrion.
Mammalian complex I is composed of 45 different subunits. This is a component of the iron-sulfur (IP) fragment of the enzyme. Interacts with RAB5IF.
Belongs to the complex I 23 kDa subunit family.
Research Fields
· Human Diseases > Endocrine and metabolic diseases > Non-alcoholic fatty liver disease (NAFLD).
· Human Diseases > Neurodegenerative diseases > Alzheimer's disease.
· Human Diseases > Neurodegenerative diseases > Parkinson's disease.
· Human Diseases > Neurodegenerative diseases > Huntington's disease.
· Metabolism > Energy metabolism > Oxidative phosphorylation.
· Metabolism > Global and overview maps > Metabolic pathways.
· Organismal Systems > Nervous system > Retrograde endocannabinoid signaling. (View pathway)
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For Research Use Only.
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