MARVELD2 Antibody - #DF9611

(2)  
Product: MARVELD2 Antibody
Catalog: DF9611
Description: Rabbit polyclonal antibody to MARVELD2
Application: WB IHC
Reactivity: Human, Mouse, Rat
Mol.Wt.: 64 kDa; 64kD(Calculated).
Uniprot: Q8N4S9
RRID: AB_2842807

View similar products>>

   Size Price Inventory
 100ul $280 In stock
 200ul $350 In stock

Lead Time: Same day delivery

For pricing and ordering contact:
Local distributors
Related Downloads
MS Report
HPLC Report
MSDS
Data Sheet
COA
Protocols
WB Handbook
IHC Protocol
IF/ICC Protocol

Product Info

Source:
Rabbit
Application:
WB 1:1000-3000, IHC 1:50-1:200
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

Reactivity:
Human,Mouse,Rat
Clonality:
Polyclonal
Specificity:
MARVELD2 Antibody detects endogenous levels of total MARVELD2.
RRID:
AB_2842807
Cite Format: Affinity Biosciences Cat# DF9611, RRID:AB_2842807.
Conjugate:
Unconjugated.
Purification:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
Storage:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
Alias:

Fold/Unfold

DFNB49; FLJ30532; MARVD2; MARVEL (membrane associating) domain containing 2; MARVEL domain containing 2; MARVEL domain containing protein 2; MARVELD 2; MARVELD2; MRVLDC2; Tric; Tricellulin;

Immunogens

Immunogen:
Uniprot:

Q8N4S9(MALD2_HUMAN) >>Visit HPA database.

Gene(ID):
MARVELD2(153562)
Sequence:
MSNDGRSRNRDRRYDEVPSDLPYQDTTIRTHPTLHDSERAVSADPLPPPPLPLQPPFGPDFYSSDTEEPAIAPDLKPVRRFVPDSWKNFFRGKKKDPEWDKPVSDIRYISDGVECSPPASPARPNHRSPLNSCKDPYGGSEGTFSSRKEADAVFPRDPYGSLDRHTQTVRTYSEKVEEYNLRYSYMKSWAGLLRILGVVELLLGAGVFACVTAYIHKDSEWYNLFGYSQPYGMGGVGGLGSMYGGYYYTGPKTPFVLVVAGLAWITTIIILVLGMSMYYRTILLDSNWWPLTEFGINVALFILYMAAAIVYVNDTNRGGLCYYPLFNTPVNAVFCRVEGGQIAAMIFLFVTMIVYLISALVCLKLWRHEAARRHREYMEQQEINEPSLSSKRKMCEMATSGDRQRDSEVNFKELRTAKMKPELLSGHIPPGHIPKPIVMPDYVAKYPVIQTDDERERYKAVFQDQFSEYKELSAEVQAVLRKFDELDAVMSRLPHHSESRQEHERISRIHEEFKKKKNDPTFLEKKERCDYLKNKLSHIKQRIQEYDKVMNWDVQGYS

PTMs - Q8N4S9 As Substrate

Site PTM Type Enzyme
Y14 Phosphorylation
Y23 Phosphorylation
T26 Phosphorylation
T27 Phosphorylation
S37 Phosphorylation
K87 Ubiquitination
K101 Ubiquitination
S104 Phosphorylation
S116 Phosphorylation
S120 Phosphorylation
S128 Phosphorylation
K134 Ubiquitination
Y137 Phosphorylation
S140 Phosphorylation
S146 Phosphorylation
K148 Ubiquitination
Y159 Phosphorylation
S161 Phosphorylation
T166 Phosphorylation
T168 Phosphorylation
S173 Phosphorylation
K175 Ubiquitination
Y377 Phosphorylation
S387 Phosphorylation
K391 Ubiquitination
S407 Phosphorylation
K412 Ubiquitination
Y442 Phosphorylation
Y446 Phosphorylation
S467 Phosphorylation
Y469 Phosphorylation
K548 Ubiquitination
Y557 Phosphorylation
S558 Phosphorylation

Research Backgrounds

Function:

Plays a role in the formation of tricellular tight junctions and of epithelial barriers (By similarity). Required for normal hearing via its role in the separation of the endolymphatic and perilymphatic spaces of the organ of Corti in the inner ear, and for normal survival of hair cells in the organ of Corti.

PTMs:

Ubiquitinated by ITCH; but this ubiquitination does not lead to proteasomal degradation.

Phosphorylated.

Subcellular Location:

Cell membrane>Multi-pass membrane protein. Cell junction>Tight junction.
Note: Found at tricellular contacts.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
Subunit Structure:

Interacts with TJP1. Interacts with the ubiquitin ligase ITCH.

Research Fields

· Cellular Processes > Cellular community - eukaryotes > Tight junction.   (View pathway)

Restrictive clause

 

Affinity Biosciences tests all products strictly. Citations are provided as a resource for additional applications that have not been validated by Affinity Biosciences. Please choose the appropriate format for each application and consult Materials and Methods sections for additional details about the use of any product in these publications.

For Research Use Only.
Not for use in diagnostic or therapeutic procedures. Not for resale. Not for distribution without written consent. Affinity Biosciences will not be held responsible for patent infringement or other violations that may occur with the use of our products. Affinity Biosciences, Affinity Biosciences Logo and all other trademarks are the property of Affinity Biosciences LTD.