ACSL5 Antibody - #DF9607
| Product: | ACSL5 Antibody |
| Catalog: | DF9607 |
| Description: | Rabbit polyclonal antibody to ACSL5 |
| Application: | WB IF/ICC |
| Reactivity: | Human, Mouse, Rat |
| Prediction: | Pig, Horse, Rabbit |
| Mol.Wt.: | 76kDa; 76kD(Calculated). |
| Uniprot: | Q9ULC5 |
| RRID: | AB_2842803 |
Related Downloads
Protocols
Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# DF9607, RRID:AB_2842803.
Fold/Unfold
ACS2; ACS5; Acyl CoA synthetase 5; Acyl CoA synthetase long chain family member 5; EC 6.2.1.3; FACL5; FACL5 for fatty acid coenzyme A ligase 5; Fatty acid CoA ligase, long chain 5; Fatty acid coenzyme A ligase 5; Fatty acid Coenzyme A ligase long chain 5; LACS 5; Long chain acyl CoA synthetase 5; Long chain fatty acid CoA ligase 5; Long chain fatty acid coenzyme A ligase 5;
Immunogens
- Q9ULC5 ACSL5_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MLFIFNFLFSPLPTPALICILTFGAAIFLWLITRPQPVLPLLDLNNQSVGIEGGARKGVSQKNNDLTSCCFSDAKTMYEVFQRGLAVSDNGPCLGYRKPNQPYRWLSYKQVSDRAEYLGSCLLHKGYKSSPDQFVGIFAQNRPEWIISELACYTYSMVAVPLYDTLGPEAIVHIVNKADIAMVICDTPQKALVLIGNVEKGFTPSLKVIILMDPFDDDLKQRGEKSGIEILSLYDAENLGKEHFRKPVPPSPEDLSVICFTSGTTGDPKGAMITHQNIVSNAAAFLKCVEHAYEPTPDDVAISYLPLAHMFERIVQAVVYSCGARVGFFQGDIRLLADDMKTLKPTLFPAVPRLLNRIYDKVQNEAKTPLKKFLLKLAVSSKFKELQKGIIRHDSFWDKLIFAKIQDSLGGRVRVIVTGAAPMSTSVMTFFRAAMGCQVYEAYGQTECTGGCTFTLPGDWTSGHVGVPLACNYVKLEDVADMNYFTVNNEGEVCIKGTNVFKGYLKDPEKTQEALDSDGWLHTGDIGRWLPNGTLKIIDRKKNIFKLAQGEYIAPEKIENIYNRSQPVLQIFVHGESLRSSLVGVVVPDTDVLPSFAAKLGVKGSFEELCQNQVVREAILEDLQKIGKESGLKTFEQVKAIFLHPEPFSIENGLLTPTLKAKRGELSKYFRTQIDSLYEHIQD
Predictions
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q9ULC5 As Substrate
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| Y96 | Phosphorylation | Uniprot | |
| Y163 | Phosphorylation | Uniprot | |
| K200 | Ubiquitination | Uniprot | |
| K220 | Ubiquitination | Uniprot | |
| K225 | Ubiquitination | Uniprot | |
| Y234 | Phosphorylation | Uniprot | |
| K241 | Methylation | Uniprot | |
| K241 | Ubiquitination | Uniprot | |
| K344 | Ubiquitination | Uniprot | |
| S380 | Phosphorylation | Uniprot | |
| S381 | Phosphorylation | Uniprot | |
| S395 | Phosphorylation | Uniprot | |
| K404 | Ubiquitination | Uniprot | |
| S408 | Phosphorylation | Uniprot | |
| K506 | Ubiquitination | Uniprot | |
| T511 | Phosphorylation | Uniprot | |
| Y552 | Phosphorylation | Uniprot | |
| K557 | Ubiquitination | Uniprot | |
| S580 | Phosphorylation | Uniprot | |
| S581 | Phosphorylation | Uniprot | |
| S595 | Phosphorylation | Uniprot | |
| K599 | Ubiquitination | Uniprot | |
| K603 | Ubiquitination | Uniprot | |
| T634 | Phosphorylation | Uniprot | |
| T656 | Phosphorylation | Uniprot | |
| Y678 | Phosphorylation | Uniprot |
Research Backgrounds
Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation. ACSL5 may activate fatty acids from exogenous sources for the synthesis of triacylglycerol destined for intracellular storage (By similarity). Utilizes a wide range of saturated fatty acids with a preference for C16-C18 unsaturated fatty acids (By similarity). It was suggested that it may also stimulate fatty acid oxidation (By similarity). At the villus tip of the crypt-villus axis of the small intestine may sensitize epithelial cells to apoptosis specifically triggered by the death ligand TRAIL. May have a role in the survival of glioma cells.
Mitochondrion. Endoplasmic reticulum. Mitochondrion outer membrane>Single-pass type III membrane protein. Endoplasmic reticulum membrane>Single-pass type III membrane protein. Cell membrane.
Belongs to the ATP-dependent AMP-binding enzyme family.
Research Fields
· Cellular Processes > Transport and catabolism > Peroxisome. (View pathway)
· Cellular Processes > Cell growth and death > Ferroptosis. (View pathway)
· Metabolism > Lipid metabolism > Fatty acid biosynthesis.
· Metabolism > Lipid metabolism > Fatty acid degradation.
· Metabolism > Global and overview maps > Metabolic pathways.
· Metabolism > Global and overview maps > Fatty acid metabolism.
· Organismal Systems > Endocrine system > PPAR signaling pathway.
· Organismal Systems > Endocrine system > Adipocytokine signaling pathway.
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