ACSL3 Antibody - #DF9606
| Product: | ACSL3 Antibody |
| Catalog: | DF9606 |
| Description: | Rabbit polyclonal antibody to ACSL3 |
| Application: | WB IF/ICC |
| Reactivity: | Human, Mouse, Rat |
| Prediction: | Pig, Bovine, Horse, Sheep, Rabbit, Dog, Chicken |
| Mol.Wt.: | 70 kDa; 80kD(Calculated). |
| Uniprot: | O95573 |
| RRID: | AB_2842802 |
Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# DF9606, RRID:AB_2842802.
Fold/Unfold
ACS3; Acsl3; ACSL3_HUMAN; Acyl CoA synthetase long chain family member 3; FACL3; Fatty acid Coenzyme A ligase long chain 3; LACS 3; LACS3; Lignoceroyl CoA synthase; Long chain acyl CoA synthetase 3; Long chain fatty acid CoA ligase 3; Long-chain acyl-CoA synthetase 3; Long-chain-fatty-acid--CoA ligase 3; PRO2194;
Immunogens
- O95573 ACSL3_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MNNHVSSKPSTMKLKHTINPILLYFIHFLISLYTILTYIPFYFFSESRQEKSNRIKAKPVNSKPDSAYRSVNSLDGLASVLYPGCDTLDKVFTYAKNKFKNKRLLGTREVLNEEDEVQPNGKIFKKVILGQYNWLSYEDVFVRAFNFGNGLQMLGQKPKTNIAIFCETRAEWMIAAQACFMYNFQLVTLYATLGGPAIVHALNETEVTNIITSKELLQTKLKDIVSLVPRLRHIITVDGKPPTWSEFPKGIIVHTMAAVEALGAKASMENQPHSKPLPSDIAVIMYTSGSTGLPKGVMISHSNIIAGITGMAERIPELGEEDVYIGYLPLAHVLELSAELVCLSHGCRIGYSSPQTLADQSSKIKKGSKGDTSMLKPTLMAAVPEIMDRIYKNVMNKVSEMSSFQRNLFILAYNYKMEQISKGRNTPLCDSFVFRKVRSLLGGNIRLLLCGGAPLSATTQRFMNICFCCPVGQGYGLTESAGAGTISEVWDYNTGRVGAPLVCCEIKLKNWEEGGYFNTDKPHPRGEILIGGQSVTMGYYKNEAKTKADFFEDENGQRWLCTGDIGEFEPDGCLKIIDRKKDLVKLQAGEYVSLGKVEAALKNLPLVDNICAYANSYHSYVIGFVVPNQKELTELARKKGLKGTWEELCNSCEMENEVLKVLSEAAISASLEKFEIPVKIRLSPEPWTPETGLVTDAFKLKRKELKTHYQADIERMYGRK
Predictions
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - O95573 As Substrate
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S6 | Phosphorylation | Uniprot | |
| K13 | Ubiquitination | Uniprot | |
| K56 | Ubiquitination | Uniprot | |
| K58 | Ubiquitination | Uniprot | |
| K63 | Ubiquitination | Uniprot | |
| K90 | Ubiquitination | Uniprot | |
| K96 | Ubiquitination | Uniprot | |
| T107 | Phosphorylation | Uniprot | |
| K122 | Acetylation | Uniprot | |
| K122 | Ubiquitination | Uniprot | |
| K157 | Ubiquitination | Uniprot | |
| C166 | S-Nitrosylation | Uniprot | |
| K220 | Ubiquitination | Uniprot | |
| K222 | Ubiquitination | Uniprot | |
| K240 | Ubiquitination | Uniprot | |
| Y351 | Phosphorylation | Uniprot | |
| S353 | Phosphorylation | Uniprot | |
| K363 | Ubiquitination | Uniprot | |
| K376 | Ubiquitination | Uniprot | |
| K392 | Ubiquitination | Uniprot | |
| K397 | Ubiquitination | Uniprot | |
| K422 | Ubiquitination | Uniprot | |
| C450 | S-Nitrosylation | Uniprot | |
| K507 | Ubiquitination | Uniprot | |
| K509 | Ubiquitination | Uniprot | |
| Y516 | Phosphorylation | Uniprot | |
| K521 | Acetylation | Uniprot | |
| K521 | Ubiquitination | Uniprot | |
| K547 | Ubiquitination | Uniprot | |
| C561 | S-Nitrosylation | Uniprot | |
| C573 | S-Nitrosylation | Uniprot | |
| K575 | Ubiquitination | Uniprot | |
| Y591 | Phosphorylation | Uniprot | |
| S593 | Phosphorylation | Uniprot | |
| K596 | Ubiquitination | Uniprot | |
| K642 | Ubiquitination | Uniprot | |
| K673 | Ubiquitination | Uniprot | |
| K679 | Ubiquitination | Uniprot | |
| S683 | Phosphorylation | Uniprot | |
| T688 | Phosphorylation | Uniprot | |
| T691 | Phosphorylation | Uniprot | |
| T695 | Phosphorylation | Uniprot | |
| K699 | Acetylation | Uniprot | |
| K699 | Ubiquitination | Uniprot | |
| K706 | Acetylation | Uniprot | |
| K706 | Ubiquitination | Uniprot | |
| Y709 | Phosphorylation | Uniprot |
Research Backgrounds
Acyl-CoA synthetases (ACSL) activates long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Required for the incorporation of fatty acids into phosphatidylcholine, the major phospholipid located on the surface of VLDL (very low density lipoproteins). Has mainly an anabolic role in energy metabolism. Mediates hepatic lipogenesis. Preferentially uses myristate, laurate, arachidonate and eicosapentaenoate as substrates. Both isoforms exhibit the same level of activity (By similarity).
Mitochondrion outer membrane>Single-pass type III membrane protein. Peroxisome membrane>Single-pass type III membrane protein. Microsome membrane>Single-pass type III membrane protein. Endoplasmic reticulum membrane>Single-pass type III membrane protein.
Belongs to the ATP-dependent AMP-binding enzyme family.
Research Fields
· Cellular Processes > Transport and catabolism > Peroxisome. (View pathway)
· Cellular Processes > Cell growth and death > Ferroptosis. (View pathway)
· Metabolism > Lipid metabolism > Fatty acid biosynthesis.
· Metabolism > Lipid metabolism > Fatty acid degradation.
· Metabolism > Global and overview maps > Metabolic pathways.
· Metabolism > Global and overview maps > Fatty acid metabolism.
· Organismal Systems > Endocrine system > PPAR signaling pathway.
· Organismal Systems > Endocrine system > Adipocytokine signaling pathway.
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