KIR2DS5 Antibody - #DF9601

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Product: KIR2DS5 Antibody
Catalog: DF9601
Description: Rabbit polyclonal antibody to KIR2DS5
Application: WB IF/ICC
Reactivity: Human
Mol.Wt.: 34 kDa; 34kD(Calculated).
Uniprot: Q14953
RRID: AB_2842797

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Related Downloads
MS Report
HPLC Report
MSDS
Data Sheet
COA
Protocols
WB Handbook
IHC Protocol
IF/ICC Protocol

Product Info

Source:
Rabbit
Application:
WB 1:1000-3000, IF/ICC 1:100-1:500
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

Reactivity:
Human
Clonality:
Polyclonal
Specificity:
KIR2DS5 Antibody detects endogenous levels of total KIR2DS5.
RRID:
AB_2842797
Cite Format: Affinity Biosciences Cat# DF9601, RRID:AB_2842797.
Conjugate:
Unconjugated.
Purification:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
Storage:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
Alias:

Fold/Unfold

CD158 antigen like family member G; CD158g; Flags: Precursor; Killer cell immunoglobulin like receptor 2DS5; Killer cell immunoglobulin like receptor two domains short cytoplasmic tail 5; KIR2DS5; MHC class I NK cell receptor; Natural killer associated transcript 9; Natural killer cell inhibitory receptor; NKAT 9; NKAT9;

Immunogens

Immunogen:
Uniprot:

Q14953(KI2S5_HUMAN) >>Visit HPA database.

Gene(ID):
KIR2DS5(3810)
Expression:
Q14953 KI2S5_HUMAN:

Expressed on a discrete subset of peripheral blood NK cells.

Sequence:
MSLMVISMACVAFFLLQGAWPHEGFRRKPSLLAHPGPLVKSEETVILQCWSDVMFEHFLLHREGTFNHTLRLIGEHIDGVSKGNFSIGRMTQDLAGTYRCYGSVTHSPYQLSAPSDPLDIVITGLYEKPSLSAQPGPTVLAGESVTLSCSSRSSYDMYHLSREGEAHERRLPAGPKVNRTFQADFPLDPATHGGTYRCFGSFRDSPYEWSKSSDPLLVSVTGNSSNSWPSPTEPSSETGNPRHLHVLIGTSVVKLPFTILLFFLLHRWCSNKKNASVMDQGPAGNRTVNREDSDEQDHQEVSYA

PTMs - Q14953 As Substrate

Site PTM Type Enzyme
N178 N-Glycosylation

Research Backgrounds

Function:

Activating natural killer (NK) receptor that recognizes C2 epitopes of HLA-C alleles. Bridging the innate and adaptive immune systems, NK cells express a number of cell surface receptors which either inhibit or stimulate their cytotoxicity. Able to activate NK cells citotoxicity and cytokine production such as IFNG. Receptor functions are attenuated even lost in some alleles, such as KIR2DS5*002 reprensented in this entry.

PTMs:

N-glycosylated, glycosylation varies depending on the allele which alters cell surface expression levels.

Subcellular Location:

Cell membrane>Single-pass type I membrane protein>Extracellular side.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
Tissue Specificity:

Expressed on a discrete subset of peripheral blood NK cells.

Subunit Structure:

Interacts with TYROBP.

Family&Domains:

Belongs to the immunoglobulin superfamily.

Research Fields

· Organismal Systems > Immune system > Antigen processing and presentation.   (View pathway)

· Organismal Systems > Immune system > Natural killer cell mediated cytotoxicity.   (View pathway)

Restrictive clause

 

Affinity Biosciences tests all products strictly. Citations are provided as a resource for additional applications that have not been validated by Affinity Biosciences. Please choose the appropriate format for each application and consult Materials and Methods sections for additional details about the use of any product in these publications.

For Research Use Only.
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