HNRPDL Antibody - #DF9571

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Product: HNRPDL Antibody
Catalog: DF9571
Description: Rabbit polyclonal antibody to HNRPDL
Application: WB IHC IF/ICC
Reactivity: Human, Mouse, Rat
Prediction: Pig, Bovine, Horse, Sheep, Rabbit, Chicken, Xenopus
Mol.Wt.: 46 kDa,37kDa; 46kD(Calculated).
Uniprot: O14979
RRID: AB_2842767

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 100ul $280 In stock
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Related Downloads
MS Report
HPLC Report
MSDS
Data Sheet
COA
Protocols
WB Handbook
IHC Protocol
IF/ICC Protocol

Product Info

Source:
Rabbit
Application:
WB 1:1000-3000, IHC 1:50-1:200, IF/ICC 1:100-1:500
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

Reactivity:
Human,Mouse,Rat
Prediction:
Pig(100%), Bovine(100%), Horse(100%), Sheep(100%), Rabbit(100%), Chicken(100%), Xenopus(91%)
Clonality:
Polyclonal
Specificity:
HNRPDL Antibody detects endogenous levels of total HNRPDL.
RRID:
AB_2842767
Cite Format: Affinity Biosciences Cat# DF9571, RRID:AB_2842767.
Conjugate:
Unconjugated.
Purification:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
Storage:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
Alias:

Fold/Unfold

A+U-rich element RNA binding factor; AA407431; AA959857; AU rich element RNA binding factor; AU-rich element RNA-binding factor; D5Ertd650e; D5Wsu145e; Heterogeneous nuclear ribonucleoprotein D like; Heterogeneous nuclear ribonucleoprotein D like protein; Heterogeneous nuclear ribonucleoprotein D-like; hnHNRP DL; HNRDL_HUMAN; HNRNP; hnRNP D-like; hnRNP DL; HNRNPDL; hnRPD like protein; JKT41 binding protein; JKT41-binding protein; JKTBP; JKTBP2; laAUF1; MGC125262; Protein laAUF1;

Immunogens

Immunogen:
Uniprot:

O14979(HNRDL_HUMAN) >>Visit HPA database.

Gene(ID):
HNRNPDL(9987)
Expression:
O14979 HNRDL_HUMAN:

Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney, pancreas, spleen, thymus, prostate, testis, ovary, small intestine, colon and leukocytes. Expressed in myeloid leukemia, gastric adenocarcinoma, cervical carcinoma, hepatoma, fibrosarcoma, colon adenocarcinoma, epidermoid carcinoma, osteosarcoma and urinary bladder carcinoma cells.

Sequence:
MEVPPRLSHVPPPLFPSAPATLASRSLSHWRPRPPRQLAPLLPSLAPSSARQGARRAQRHVTAQQPSRLAGGAAIKGGRRRRPDLFRRHFKSSSIQRSAAAAAATRTARQHPPADSSVTMEDMNEYSNIEEFAEGSKINASKNQQDDGKMFIGGLSWDTSKKDLTEYLSRFGEVVDCTIKTDPVTGRSRGFGFVLFKDAASVDKVLELKEHKLDGKLIDPKRAKALKGKEPPKKVFVGGLSPDTSEEQIKEYFGAFGEIENIELPMDTKTNERRGFCFITYTDEEPVKKLLESRYHQIGSGKCEIKVAQPKEVYRQQQQQQKGGRGAAAGGRGGTRGRGRGQGQNWNQGFNNYYDQGYGNYNSAYGGDQNYSGYGGYDYTGYNYGNYGYGQGYADYSGQQSTYGKASRGGGNHQNNYQPY

Predictions

Predictions:

Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.

Species
Results
Score
Pig
100
Horse
100
Bovine
100
Sheep
100
Chicken
100
Rabbit
100
Xenopus
91
Zebrafish
75
Dog
0
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

PTMs - O14979 As Substrate

Site PTM Type Enzyme
R6 Methylation
S24 Phosphorylation
R25 Methylation
R68 Methylation
K76 Methylation
K76 Ubiquitination
R81 Methylation
R82 Methylation
S94 Phosphorylation
S98 Phosphorylation
S117 Phosphorylation
T119 Phosphorylation
Y126 Phosphorylation
S127 Phosphorylation
S136 Phosphorylation
K137 Acetylation
K137 Ubiquitination
K142 Ubiquitination
K149 Ubiquitination
S156 Phosphorylation
S160 Phosphorylation
K161 Acetylation
K161 Methylation
K161 Ubiquitination
K162 Ubiquitination
T165 Phosphorylation
Y167 Phosphorylation
S169 Phosphorylation
C177 S-Nitrosylation
T178 Phosphorylation
K180 Acetylation
K180 Ubiquitination
R189 Methylation
K197 Acetylation
K197 Ubiquitination
K204 Acetylation
K204 Ubiquitination
K209 Ubiquitination
K216 Acetylation
K216 Ubiquitination
K234 Ubiquitination
S241 Phosphorylation
T244 Phosphorylation
K269 Ubiquitination
K288 Ubiquitination
Y295 Phosphorylation
S300 Phosphorylation
K302 Acetylation
K302 Ubiquitination
K306 Ubiquitination
K311 Ubiquitination
Y314 Phosphorylation
Y387 Phosphorylation
Y389 Phosphorylation
Y396 Phosphorylation
R408 Methylation
Y417 Phosphorylation
Y420 Phosphorylation

Research Backgrounds

Function:

Acts as a transcriptional regulator. Promotes transcription repression. Promotes transcription activation in differentiated myotubes (By similarity). Binds to double- and single-stranded DNA sequences. Binds to the transcription suppressor CATR sequence of the COX5B promoter (By similarity). Binds with high affinity to RNA molecules that contain AU-rich elements (AREs) found within the 3'-UTR of many proto-oncogenes and cytokine mRNAs. Binds both to nuclear and cytoplasmic poly(A) mRNAs. Binds to poly(G) and poly(A), but not to poly(U) or poly(C) RNA homopolymers. Binds to the 5'-ACUAGC-3' RNA consensus sequence.

PTMs:

Dimethylation of Arg-408 is probably of the asymmetric type.

Subcellular Location:

Nucleus. Cytoplasm.
Note: Shuttles between the nucleus and the cytoplasm in a TNPO1-dependent manner.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
Tissue Specificity:

Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney, pancreas, spleen, thymus, prostate, testis, ovary, small intestine, colon and leukocytes. Expressed in myeloid leukemia, gastric adenocarcinoma, cervical carcinoma, hepatoma, fibrosarcoma, colon adenocarcinoma, epidermoid carcinoma, osteosarcoma and urinary bladder carcinoma cells.

Subunit Structure:

Interacts with ZNF148 (By similarity). Interacts with TNPO1.

Restrictive clause

 

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For Research Use Only.
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