FAIM2 Antibody - #DF9515
| Product: | FAIM2 Antibody |
| Catalog: | DF9515 |
| Description: | Rabbit polyclonal antibody to FAIM2 |
| Application: | WB |
| Reactivity: | Human |
| Prediction: | Pig, Bovine, Horse, Sheep, Rabbit, Dog, Chicken, Xenopus |
| Mol.Wt.: | 35 kDa; 35kD(Calculated). |
| Uniprot: | Q9BWQ8 |
| RRID: | AB_2842711 |
Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# DF9515, RRID:AB_2842711.
Fold/Unfold
FAIM 2; Faim2; FAIM2_HUMAN; Fas apoptotic inhibitory molecule 2; KIAA0950; LFG; Lifeguard; Neural membrane protein 35; NGP 35; NGP35; NMP 35; NMP35; Protein lifeguard; TMBIM 2; TMBIM2; Transmembrane BAX inhibitor motif containing 2; Transmembrane BAX inhibitor motif containing protein 2; Transmembrane BAX inhibitor motif-containing protein 2;
Immunogens
Highly expressed in breast carcinoma tissues. Enhanced expression correlates with the grade of the tumor (grade II/grade III) in primary breast tumors (at protein level). Widely expressed. Expressed at high levels in the brain especially in the hippocampus.
- Q9BWQ8 LFG2_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MTQGKLSVANKAPGTEGQQQVHGEKKEAPAVPSAPPSYEEATSGEGMKAGAFPPAPTAVPLHPSWAYVDPSSSSSYDNGFPTGDHELFTTFSWDDQKVRRVFVRKVYTILLIQLLVTLAVVALFTFCDPVKDYVQANPGWYWASYAVFFATYLTLACCSGPRRHFPWNLILLTVFTLSMAYLTGMLSSYYNTTSVLLCLGITALVCLSVTVFSFQTKFDFTSCQGVLFVLLMTLFFSGLILAILLPFQYVPWLHAVYAALGAGVFTLFLALDTQLLMGNRRHSLSPEEYIFGALNIYLDIIYIFTFFLQLFGTNRE
Predictions
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q9BWQ8 As Substrate
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| K11 | Acetylation | Uniprot | |
| S33 | Phosphorylation | Uniprot | |
| Y38 | Phosphorylation | Uniprot | |
| T42 | Phosphorylation | Uniprot |
Research Backgrounds
Antiapoptotic protein which protects cells uniquely from Fas-induced apoptosis. Regulates Fas-mediated apoptosis in neurons by interfering with caspase-8 activation. May play a role in cerebellar development by affecting cerebellar size, internal granular layer (IGL) thickness, and Purkinje cell (PC) development.
Cell membrane>Multi-pass membrane protein. Membrane raft. Cell junction>Synapse>Postsynaptic cell membrane.
Highly expressed in breast carcinoma tissues. Enhanced expression correlates with the grade of the tumor (grade II/grade III) in primary breast tumors (at protein level). Widely expressed. Expressed at high levels in the brain especially in the hippocampus.
Interacts with FAS/TNFRSF6 and BAX.
Belongs to the BI1 family. LFG subfamily.
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