EDEM3 Antibody - #DF9504
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Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# DF9504, RRID:AB_2842700.
Fold/Unfold
alpha-1,2-mannosidase EDEM3; C1orf22; EDEM 3; edem3; EDEM3_HUMAN; ER degradation enhancer, mannosidase alpha like 3; ER degradation enhancing alpha mannosidase like 3; ER degradation enhancing alpha mannosidase like protein 3; ER degradation-enhancing alpha-mannosidase-like 3;
Immunogens
- Q9BZQ6 EDEM3_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MSEAGGRGCGSPVPQRARWRLVAATAAFCLVSATSVWTAGAEPMSREEKQKLGNQVLEMFDHAYGNYMEHAYPADELMPLTCRGRVRGQEPSRGDVDDALGKFSLTLIDSLDTLVVLNKTKEFEDAVRKVLRDVNLDNDVVVSVFETNIRVLGGLLGGHSLAIMLKEKGEYMQWYNDELLQMAKQLGYKLLPAFNTTSGLPYPRINLKFGIRKPEARTGTETDTCTACAGTLILEFAALSRFTGATIFEEYARKALDFLWEKRQRSSNLVGVTINIHTGDWVRKDSGVGAGIDSYYEYLLKAYVLLGDDSFLERFNTHYDAIMRYISQPPLLLDVHIHKPMLNARTWMDALLAFFPGLQVLKGDIRPAIETHEMLYQVIKKHNFLPEAFTTDFRVHWAQHPLRPEFAESTYFLYKATGDPYYLEVGKTLIENLNKYARVPCGFAAMKDVRTGSHEDRMDSFFLAEMFKYLYLLFADKEDIIFDIEDYIFTTEAHLLPLWLSTTNQSISKKNTTSEYTELDDSNFDWTCPNTQILFPNDPLYAQSIREPLKNVVDKSCPRGIIRVEESFRSGAKPPLRARDFMATNPEHLEILKKMGVSLIHLKDGRVQLVQHAIQAASSIDAEDGLRFMQEMIELSSQQQKEQQLPPRAVQIVSHPFFGRVVLTAGPAQFGLDLSKHKETRGFVASSKPSNGCSELTNPEAVMGKIALIQRGQCMFAEKARNIQNAGAIGGIVIDDNEGSSSDTAPLFQMAGDGKDTDDIKIPMLFLFSKEGSIILDAIREYEEVEVLLSDKAKDRDPEMENEEQPSSENDSQNQSGEQISSSSQEVDLVDQESSEENSLNSHPESLSLADMDNAASISPSEQTSNPTENHETTNLNGECTDLDNQLQEQSETEEDSNPNVSWGKKVQPIDSILADWNEDIEAFEMMEKDEL
Predictions
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q9BZQ6 As Substrate
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| K189 | Ubiquitination | Uniprot | |
| N195 | N-Glycosylation | Uniprot | |
| K208 | Ubiquitination | Uniprot | |
| K262 | Ubiquitination | Uniprot | |
| S286 | Phosphorylation | Uniprot | |
| Y295 | Phosphorylation | Uniprot | |
| Y296 | Phosphorylation | Uniprot | |
| K427 | Ubiquitination | Uniprot | |
| K435 | Ubiquitination | Uniprot | |
| K447 | Ubiquitination | Uniprot | |
| K550 | Ubiquitination | Uniprot | |
| K555 | Ubiquitination | Uniprot | |
| K573 | Ubiquitination | Uniprot | |
| K594 | Ubiquitination | Uniprot | |
| S686 | Phosphorylation | Uniprot | |
| K705 | Ubiquitination | Uniprot | |
| K719 | Ubiquitination | Uniprot | |
| S835 | Phosphorylation | Uniprot |
Research Backgrounds
Involved in endoplasmic reticulum-associated degradation (ERAD). Accelerates the glycoprotein ERAD by proteasomes, by catalyzing mannose trimming from Man8GlcNAc2 to Man7GlcNAc2 in the N-glycans. Seems to have alpha 1,2-mannosidase activity (By similarity).
Endoplasmic reticulum lumen.
Contains a protease-associated domain (PA) of unknown function.
Belongs to the glycosyl hydrolase 47 family.
Research Fields
· Genetic Information Processing > Folding, sorting and degradation > Protein processing in endoplasmic reticulum. (View pathway)
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