PDE2A Antibody - #DF9370
| Product: | PDE2A Antibody |
| Catalog: | DF9370 |
| Description: | Rabbit polyclonal antibody to PDE2A |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Prediction: | Pig, Bovine, Horse, Sheep, Rabbit, Dog |
| Mol.Wt.: | 106 kDa; 106kD(Calculated). |
| Uniprot: | O00408 |
| RRID: | AB_2842566 |
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Protocols
Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# DF9370, RRID:AB_2842566.
Fold/Unfold
5''-cyclic phosphodiesterase; cGMP dependent 3'5' cyclic phosphodiesterase; cGMP stimulated phosphodiesterase 1; cGMP stimulated phosphodiesterase 4; cGMP-dependent 3''; cGMP-stimulated phosphodiesterase 2; CGS PDE; CGS-PDE; cGSPDE; Cyclic GMP stimulated phosphodiesterase; Cyclic GMP-stimulated phosphodiesterase; Human cGMP stimulated 3'5' cyclic nucleotide phosphodiesterase; PDE 2A; PDE 2A1; PDE 2A4; PDE2A; PDE2A_HUMAN; PDE2A1; PDE2A4; phosphodiesterase 2A; Phosphodiesterase 2A cGMP stimulated;
Immunogens
Expressed in brain and to a lesser extent in heart, placenta, lung, skeletal muscle, kidney and pancreas.
- O00408 PDE2A_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MGQACGHSILCRSQQYPAARPAEPRGQQVFLKPDEPPPPPQPCADSLQDALLSLGSVIDISGLQRAVKEALSAVLPRVETVYTYLLDGESQLVCEDPPHELPQEGKVREAIISQKRLGCNGLGFSDLPGKPLARLVAPLAPDTQVLVMPLADKEAGAVAAVILVHCGQLSDNEEWSLQAVEKHTLVALRRVQVLQQRGPREAPRAVQNPPEGTAEDQKGGAAYTDRDRKILQLCGELYDLDASSLQLKVLQYLQQETRASRCCLLLVSEDNLQLSCKVIGDKVLGEEVSFPLTGCLGQVVEDKKSIQLKDLTSEDVQQLQSMLGCELQAMLCVPVISRATDQVVALACAFNKLEGDLFTDEDEHVIQHCFHYTSTVLTSTLAFQKEQKLKCECQALLQVAKNLFTHLDDVSVLLQEIITEARNLSNAEICSVFLLDQNELVAKVFDGGVVDDESYEIRIPADQGIAGHVATTGQILNIPDAYAHPLFYRGVDDSTGFRTRNILCFPIKNENQEVIGVAELVNKINGPWFSKFDEDLATAFSIYCGISIAHSLLYKKVNEAQYRSHLANEMMMYHMKVSDDEYTKLLHDGIQPVAAIDSNFASFTYTPRSLPEDDTSMAILSMLQDMNFINNYKIDCPTLARFCLMVKKGYRDPPYHNWMHAFSVSHFCYLLYKNLELTNYLEDIEIFALFISCMCHDLDHRGTNNSFQVASKSVLAALYSSEGSVMERHHFAQAIAILNTHGCNIFDHFSRKDYQRMLDLMRDIILATDLAHHLRIFKDLQKMAEVGYDRNNKQHHRLLLCLLMTSCDLSDQTKGWKTTRKIAELIYKEFFSQGDLEKAMGNRPMEMMDREKAYIPELQISFMEHIAMPIYKLLQDLFPKAAELYERVASNREHWTKVSHKFTIRGLPSNNSLDFLDEEYEVPDLDGTRAPINGCCSLDAE
Predictions
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - O00408 As Substrate
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| G2 | Myristoylation | Uniprot | |
| S13 | Phosphorylation | Uniprot | |
| S125 | Phosphorylation | Uniprot | |
| T213 | Phosphorylation | Uniprot | |
| K508 | Ubiquitination | Uniprot | |
| K523 | Ubiquitination | Uniprot | |
| Y573 | Phosphorylation | Uniprot | |
| Y582 | Phosphorylation | Uniprot | |
| K584 | Ubiquitination | Uniprot | |
| K712 | Ubiquitination | Uniprot | |
| Y754 | Phosphorylation | Uniprot | |
| Y854 | Phosphorylation | Uniprot | |
| Y871 | Phosphorylation | Uniprot | |
| K880 | Ubiquitination | Uniprot | |
| S912 | Phosphorylation | Uniprot | |
| Y920 | Phosphorylation | Uniprot |
Research Backgrounds
Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Plays an important role in growth and invasion of malignant melanoma cells (e.g. pseudomyxoma peritonei (PMP) cell line).
Regulates mitochondrial cAMP levels and respiration (By similarity). Involved in the regulation of mitochondria morphology/dynamics and apoptotic cell death via local modulation of cAMP/PKA signaling in the mitochondrion, including the monitoring of local cAMP levels at the outer mitochondrial membrane and of PKA-dependent phosphorylation of DNM1L.
Cell membrane>Lipid-anchor.
Mitochondrion matrix. Mitochondrion inner membrane. Mitochondrion outer membrane.
Cytoplasm.
Mitochondrion.
Expressed in brain and to a lesser extent in heart, placenta, lung, skeletal muscle, kidney and pancreas.
Homodimer.
GAF 1 functions as a dimerization domain, whereas GAF 2 binds cGMP, which causes activation of the catalytic activity of the enzyme.
Belongs to the cyclic nucleotide phosphodiesterase family. PDE2 subfamily.
Research Fields
· Environmental Information Processing > Signal transduction > cGMP-PKG signaling pathway. (View pathway)
· Human Diseases > Substance dependence > Morphine addiction.
· Metabolism > Nucleotide metabolism > Purine metabolism.
· Organismal Systems > Sensory system > Olfactory transduction.
· Organismal Systems > Endocrine system > Aldosterone synthesis and secretion.
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