M6PR Antibody - #DF9354
| Product: | M6PR Antibody |
| Catalog: | DF9354 |
| Description: | Rabbit polyclonal antibody to M6PR |
| Application: | WB IHC |
| Reactivity: | Human, Mouse, Rat |
| Prediction: | Pig, Bovine, Horse, Sheep, Rabbit, Dog |
| Mol.Wt.: | 31 kDa; 31kD(Calculated). |
| Uniprot: | P20645 |
| RRID: | AB_2842550 |
Related Downloads
Protocols
Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# DF9354, RRID:AB_2842550.
Fold/Unfold
46 kDa mannose 6 phosphate receptor; 46 kDa mannose 6-phosphate receptor; Cation dependent mannose 6 phosphate receptor; Cation dependent mannose 6 phosphate receptor precursor; Cation-dependent mannose-6-phosphate receptor; CD Man 6 P receptor; CD Man-6-P receptor; CD MPR; CD-M6PR; CD-MPR; FLJ32994; M6pr; M6PR protein; Man6PR; Mannose 6 phosphate receptor (cation dependent); Mannose 6 phosphate receptor; MPR 46; MPR46; MPRD; MPRD_HUMAN; Mr 46,000 Man6PR; Small mannose 6 phosphate receptor; SMPR;
Immunogens
- P20645 MPRD_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MFPFYSCWRTGLLLLLLAVAVRESWQTEEKTCDLVGEKGKESEKELALVKRLKPLFNKSFESTVGQGSDTYIYIFRVCREAGNHTSGAGLVQINKSNGKETVVGRLNETHIFNGSNWIMLIYKGGDEYDNHCGKEQRRAVVMISCNRHTLADNFNPVSEERGKVQDCFYLFEMDSSLACSPEISHLSVGSILLVTFASLVAVYVVGGFLYQRLVVGAKGMEQFPHLAFWQDLGNLVADGCDFVCRSKPRNVPAAYRGVGDDQLGEESEERDDHLLPM
Predictions
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - P20645 As Substrate
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| K44 | Ubiquitination | Uniprot | |
| K50 | Ubiquitination | Uniprot | |
| N83 | N-Glycosylation | Uniprot | |
| N107 | N-Glycosylation | Uniprot | |
| S267 | Phosphorylation | Uniprot |
Research Backgrounds
Transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex.
Lysosome membrane>Single-pass type I membrane protein.
Homodimer. Binds GGA1, GGA2 and GGA3.
The extracellular domain is homologous to the repeating units (of approximately 147 AA) of the cation-independent mannose 6-phosphate receptor.
Research Fields
· Cellular Processes > Transport and catabolism > Lysosome. (View pathway)
· Cellular Processes > Transport and catabolism > Phagosome. (View pathway)
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