CHST12 Antibody - #DF9328
| Product: | CHST12 Antibody |
| Catalog: | DF9328 |
| Description: | Rabbit polyclonal antibody to CHST12 |
| Application: | WB IHC |
| Reactivity: | Human, Mouse, Rat |
| Prediction: | Pig, Bovine, Horse, Sheep, Rabbit, Dog, Chicken, Xenopus |
| Mol.Wt.: | 48 kDa; 48kD(Calculated). |
| Uniprot: | Q9NRB3 |
| RRID: | AB_2842524 |
Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# DF9328, RRID:AB_2842524.
Fold/Unfold
C4S 2; C4S2; C4ST 2; C4ST2; Carbohydrate (chondroitin 4) sulfotransferase 12; Chondroitin 4 O sulfotransferase 2; Chondroitin 4 sulfotransferase 2; Sulfotransferase Hlo;
Immunogens
Widely expressed. Expressed a high level in spinal chord, heart, spleen, thyroid, pituitary gland, adrenal gland, peripheral blood leukocytes, thymus, lung, small intestine, fetal kidney, fetal spleen and fetal lung.
- Q9NRB3 CHSTC_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MTKARLFRLWLVLGSVFMILLIIVYWDSAGAAHFYLHTSFSRPHTGPPLPTPGPDRDRELTADSDVDEFLDKFLSAGVKQSDLPRKETEQPPAPGSMEESVRGYDWSPRDARRSPDQGRQQAERRSVLRGFCANSSLAFPTKERAFDDIPNSELSHLIVDDRHGAIYCYVPKVACTNWKRVMIVLSGSLLHRGAPYRDPLRIPREHVHNASAHLTFNKFWRRYGKLSRHLMKVKLKKYTKFLFVRDPFVRLISAFRSKFELENEEFYRKFAVPMLRLYANHTSLPASAREAFRAGLKVSFANFIQYLLDPHTEKLAPFNEHWRQVYRLCHPCQIDYDFVGKLETLDEDAAQLLQLLQVDRQLRFPPSYRNRTASSWEEDWFAKIPLAWRQQLYKLYEADFVLFGYPKPENLLRD
Predictions
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q9NRB3 As Substrate
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| K72 | Ubiquitination | Uniprot | |
| S75 | Phosphorylation | Uniprot | |
| K79 | Ubiquitination | Uniprot | |
| K86 | Ubiquitination | Uniprot | |
| T88 | O-Glycosylation | Uniprot | |
| K142 | Ubiquitination | Uniprot | |
| K172 | Ubiquitination | Uniprot | |
| K240 | Ubiquitination | Uniprot | |
| K258 | Ubiquitination | Uniprot | |
| Y396 | Phosphorylation | Uniprot | |
| Y405 | Phosphorylation | Uniprot |
Research Backgrounds
Catalyzes the transfer of sulfate to position 4 of the N-acetylgalactosamine (GalNAc) residue of chondroitin and desulfated dermatan sulfate. Chondroitin sulfate constitutes the predominant proteoglycan present in cartilage and is distributed on the surfaces of many cells and extracellular matrices. Activity toward partially desulfated dermatan sulfate is however lower. Does not form 4, 6-di-O-sulfated GalNAc when chondroitin sulfate C is used as an acceptor.
Golgi apparatus membrane>Single-pass type II membrane protein.
Widely expressed. Expressed a high level in spinal chord, heart, spleen, thyroid, pituitary gland, adrenal gland, peripheral blood leukocytes, thymus, lung, small intestine, fetal kidney, fetal spleen and fetal lung.
Belongs to the sulfotransferase 2 family.
Research Fields
· Metabolism > Glycan biosynthesis and metabolism > Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate.
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