SLC25A5 Antibody - #DF9179

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Product: SLC25A5 Antibody
Catalog: DF9179
Description: Rabbit polyclonal antibody to SLC25A5
Application: WB
Reactivity: Human, Mouse, Rat
Prediction: Pig, Zebrafish, Bovine, Horse, Sheep, Rabbit, Dog, Chicken, Xenopus
Mol.Wt.: 33 kDa; 33kD(Calculated).
Uniprot: P05141
RRID: AB_2842375

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Related Downloads
MS Report
HPLC Report
MSDS
Data Sheet
COA
Protocols
WB Handbook
IHC Protocol
IF/ICC Protocol

Product Info

Source:
Rabbit
Application:
WB 1:1000-3000
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

Reactivity:
Human,Mouse,Rat
Prediction:
Pig(100%), Zebrafish(100%), Bovine(100%), Horse(90%), Sheep(100%), Rabbit(100%), Dog(100%), Chicken(100%), Xenopus(88%)
Clonality:
Polyclonal
Specificity:
SLC25A5 Antibody detects endogenous levels of total SLC25A5.
RRID:
AB_2842375
Cite Format: Affinity Biosciences Cat# DF9179, RRID:AB_2842375.
Conjugate:
Unconjugated.
Purification:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
Storage:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
Alias:

Fold/Unfold

2F1; AAC2; Adenine nucleotide translocator 2; ADP; ADP ATP carrier protein 2; ADP/ATP translocase 2; ADT2_HUMAN; ANT 2; ANT2; ATP carrier protein 2; ATP carrier protein; fibroblast isoform; OTTHUMP00000024324; SLC25A5; Solute carrier family 25 (mitochondrial carrier adenine nucleotide translocator) member 5; Solute carrier family 25 member 5; T2; T3;

Immunogens

Immunogen:
Uniprot:

P05141(ADT2_HUMAN) >>Visit HPA database.

Gene(ID):
SLC25A5(292)
Sequence:
MTDAAVSFAKDFLAGGVAAAISKTAVAPIERVKLLLQVQHASKQITADKQYKGIIDCVVRIPKEQGVLSFWRGNLANVIRYFPTQALNFAFKDKYKQIFLGGVDKRTQFWLYFAGNLASGGAAGATSLCFVYPLDFARTRLAADVGKAGAEREFRGLGDCLVKIYKSDGIKGLYQGFNVSVQGIIIYRAAYFGIYDTAKGMLPDPKNTHIVISWMIAQTVTAVAGLTSYPFDTVRRRMMMQSGRKGTDIMYTGTLDCWRKIARDEGGKAFFKGAWSNVLRGMGGAFVLVLYDEIKKYT

Predictions

Predictions:

Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.

Species
Results
Score
Pig
100
Bovine
100
Sheep
100
Dog
100
Zebrafish
100
Chicken
100
Rabbit
100
Horse
90
Xenopus
88
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

PTMs - P05141 As Substrate

Site PTM Type Enzyme
M1 Acetylation
T2 Acetylation
T2 Phosphorylation
S7 Phosphorylation
K10 Acetylation
K10 Methylation
K10 Ubiquitination
S22 Phosphorylation
K23 Acetylation
K23 Ubiquitination
T24 Phosphorylation
K33 Acetylation
K33 Ubiquitination
S42 Phosphorylation
K43 Acetylation
K43 Methylation
K43 Ubiquitination
K49 Ubiquitination
K52 Acetylation
K52 Methylation
K52 Ubiquitination
K63 Acetylation
K63 Ubiquitination
S69 Phosphorylation
Y81 Phosphorylation
T84 Phosphorylation
K92 Acetylation
K92 Ubiquitination
K94 Acetylation
K96 Acetylation
K96 Ubiquitination
K105 Acetylation
K105 Ubiquitination
Y112 Phosphorylation
S119 Phosphorylation
C129 S-Nitrosylation
T139 Phosphorylation
R140 Methylation
K147 Methylation
K147 Ubiquitination
R155 Methylation
C160 S-Nitrosylation
K163 Acetylation
K163 Ubiquitination
K166 Methylation
K166 Ubiquitination
S167 Phosphorylation
Y191 Phosphorylation
Y195 Phosphorylation
T197 Phosphorylation
K199 Acetylation
K199 Sumoylation
K199 Ubiquitination
K206 Sumoylation
S242 Phosphorylation
K245 Ubiquitination
T247 Phosphorylation
T252 Phosphorylation
T254 Phosphorylation
C257 S-Nitrosylation
K268 Acetylation
K268 Ubiquitination
K272 Acetylation
K272 Methylation
K272 Ubiquitination
S276 Phosphorylation
K295 Acetylation
K295 Ubiquitination
Y297 Phosphorylation

Research Backgrounds

Function:

Catalyzes the exchange of cytoplasmic ADP with mitochondrial ATP across the mitochondrial inner membrane. As part of the mitotic spindle-associated MMXD complex it may play a role in chromosome segregation.

PTMs:

Trimethylated by ANTKMT at Lys-52.

Subcellular Location:

Mitochondrion inner membrane>Multi-pass membrane protein.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
Subunit Structure:

Homodimer. Component of the MMXD complex, which includes CIAO1, ERCC2, CIAO2B, MMS19 and SLC25A5. Interacts with AK4.

(Microbial infection) Interacts with HIV-1 Vpr.

Family&Domains:

The transmembrane helices are not perpendicular to the plane of the membrane, but cross the membrane at an angle. Odd-numbered transmembrane helices exhibit a sharp kink, due to the presence of a conserved proline residue.

Belongs to the mitochondrial carrier (TC 2.A.29) family.

Research Fields

· Cellular Processes > Cell growth and death > Necroptosis.   (View pathway)

· Cellular Processes > Cell growth and death > Cellular senescence.   (View pathway)

· Environmental Information Processing > Signal transduction > Calcium signaling pathway.   (View pathway)

· Environmental Information Processing > Signal transduction > cGMP-PKG signaling pathway.   (View pathway)

· Human Diseases > Neurodegenerative diseases > Parkinson's disease.

· Human Diseases > Neurodegenerative diseases > Huntington's disease.

· Human Diseases > Infectious diseases: Viral > HTLV-I infection.

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