ZHX2 Antibody - #DF8899
| Product: | ZHX2 Antibody |
| Catalog: | DF8899 |
| Description: | Rabbit polyclonal antibody to ZHX2 |
| Application: | WB IHC |
| Reactivity: | Human, Mouse |
| Prediction: | Pig, Bovine, Horse, Sheep, Rabbit, Dog |
| Mol.Wt.: | 92 kDa; 92kD(Calculated). |
| Uniprot: | Q9Y6X8 |
| RRID: | AB_2842095 |
Related Downloads
Protocols
Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# DF8899, RRID:AB_2842095.
Fold/Unfold
AFP regulator 1; AFR1; Alpha fetoprotein regulator 1; Alpha-fetoprotein regulator 1; KIAA0854; RAF; Regulator of AFP; Transcription factor ZHX2; ZHX2; ZHX2_HUMAN; Zinc finger and homeodomain protein 2; Zinc fingers and homeoboxes 2; Zinc fingers and homeoboxes protein 2;
Immunogens
- Q9Y6X8 ZHX2_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MASKRKSTTPCMVRTSQVVEQDVPEEVDRAKEKGIGTPQPDVAKDSWAAELENSSKENEVIEVKSMGESQSKKLQGGYECKYCPYSTQNLNEFTEHVDMQHPNVILNPLYVCAECNFTTKKYDSLSDHNSKFHPGEANFKLKLIKRNNQTVLEQSIETTNHVVSITTSGPGTGDSDSGISVSKTPIMKPGKPKADAKKVPKKPEEITPENHVEGTARLVTDTAEILSRLGGVELLQDTLGHVMPSVQLPPNINLVPKVPVPLNTTKYNSALDTNATMINSFNKFPYPTQAELSWLTAASKHPEEHIRIWFATQRLKHGISWSPEEVEEARKKMFNGTIQSVPPTITVLPAQLAPTKVTQPILQTALPCQILGQTSLVLTQVTSGSTTVSCSPITLAVAGVTNHGQKRPLVTPQAAPEPKRPHIAQVPEPPPKVANPPLTPASDRKKTKEQIAHLKASFLQSQFPDDAEVYRLIEVTGLARSEIKKWFSDHRYRCQRGIVHITSESLAKDQLAIAASRHGRTYHAYPDFAPQKFKEKTQGQVKILEDSFLKSSFPTQAELDRLRVETKLSRREIDSWFSERRKLRDSMEQAVLDSMGSGKKGQDVGAPNGALSRLDQLSGAQLTSSLPSPSPAIAKSQEQVHLLRSTFARTQWPTPQEYDQLAAKTGLVRTEIVRWFKENRCLLKTGTVKWMEQYQHQPMADDHGYDAVARKATKPMAESPKNGGDVVPQYYKDPKKLCEEDLEKLVTRVKVGSEPAKDCLPAKPSEATSDRSEGSSRDGQGSDENEESSVVDYVEVTVGEEDAISDRSDSWSQAAAEGVSELAESDSDCVPAEAGQA
Predictions
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q9Y6X8 As Substrate
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S7 | Phosphorylation | Uniprot | |
| T8 | Phosphorylation | Uniprot | |
| T9 | Phosphorylation | Uniprot | |
| T37 | Phosphorylation | Uniprot | |
| T207 | Phosphorylation | Uniprot | |
| T215 | Phosphorylation | Uniprot | |
| T220 | Phosphorylation | Uniprot | |
| T222 | Phosphorylation | Uniprot | |
| Y267 | Phosphorylation | Uniprot | |
| S269 | Phosphorylation | Uniprot | |
| T344 | Phosphorylation | Uniprot | |
| T355 | Phosphorylation | Uniprot | |
| T401 | Phosphorylation | Uniprot | |
| T411 | Phosphorylation | Uniprot | |
| T439 | Phosphorylation | Uniprot | |
| S442 | Phosphorylation | Uniprot | |
| K455 | Ubiquitination | Uniprot | |
| Y470 | Phosphorylation | Uniprot | |
| T566 | Phosphorylation | Uniprot | |
| S569 | Phosphorylation | Uniprot | |
| S586 | Phosphorylation | Uniprot | |
| S625 | Phosphorylation | Uniprot | |
| S628 | Phosphorylation | Uniprot | |
| T654 | Phosphorylation | Uniprot | |
| Y658 | Phosphorylation | Uniprot | |
| Y705 | Phosphorylation | Uniprot | |
| T713 | Phosphorylation | Uniprot | |
| S719 | Phosphorylation | Uniprot | |
| S769 | Phosphorylation | Uniprot | |
| S775 | Phosphorylation | Uniprot | |
| S776 | Phosphorylation | Uniprot |
Research Backgrounds
Acts as a transcriptional repressor. Represses the promoter activity of the CDC25C gene stimulated by NFYA. May play a role in retinal development where it regulates the composition of bipolar cell populations, by promoting differentiation of bipolar OFF-type cells (By similarity). In the brain, may promote maintenance and suppress differentiation of neural progenitor cells in the developing cortex (By similarity).
Nucleus.
Note: Colocalizes with EFNB1 intracellular domain in the nucleus.
Ubiquitously expressed. Expressed in podocytes.
Homodimer (via homeobox domain). Heterodimer with ZHX1 (via homeobox domain 1). Heterodimer with ZHX3 (via homeobox domain 1). Heterodimerization with ZHX1 is not necessary for repressor activity. Interacts (via homeobox domain) with NFYA (via N-terminus). Interacts with EFNB1 intracellular domain peptide; the interaction enhances ZHX2 transcriptional repression activity (By similarity).
Belongs to the ZHX family.
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