MYST4 Antibody - #DF8854

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Product: MYST4 Antibody
Catalog: DF8854
Description: Rabbit polyclonal antibody to MYST4
Application: WB IHC
Reactivity: Human, Mouse
Prediction: Pig, Bovine, Horse, Sheep, Rabbit, Dog, Chicken
Mol.Wt.: 231kda; 231kD(Calculated).
Uniprot: Q8WYB5
RRID: AB_2842051

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 100ul $280 In stock
 200ul $350 In stock

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Related Downloads
MS Report
HPLC Report
MSDS
Data Sheet
COA
Protocols
WB Handbook
IHC Protocol
IF/ICC Protocol

Product Info

Source:
Rabbit
Application:
WB 1:1000-3000, IHC 1:50-1:200
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

Reactivity:
Human,Mouse
Prediction:
Pig(100%), Bovine(100%), Horse(100%), Sheep(100%), Rabbit(100%), Dog(100%), Chicken(100%)
Clonality:
Polyclonal
Specificity:
MYST4 Antibody detects endogenous levels of total MYST4.
RRID:
AB_2842051
Cite Format: Affinity Biosciences Cat# DF8854, RRID:AB_2842051.
Conjugate:
Unconjugated.
Purification:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
Storage:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
Alias:

Fold/Unfold

DKFZp313G1618; FLJ90335; Histone acetyltransferase MORF; Histone acetyltransferase MOZ2; Histone acetyltransferase MYST4; KAT 6B; KIAA0383; Monocytic leukemia zinc finger protein related factor; Monocytic leukemia zinc finger protein-related factor; MOZ 2; MOZ; MOZ related factor; MOZ YBF2/SAS3 SAS2 and TIP60 protein 4; MOZ2; MYST 4; MYST histone acetyltransferase (monocytic leukemia) 4; MYST protein 4; MYST-4; MYST4; MYST4_HUMAN; OTTHUMP00000019866; OTTHUMP00000019867; OTTHUMP00000019869; OTTHUMP00000019870; QKF; Querkopf; SAS2 and TIP60 protein 4; YBF2/SAS3;

Immunogens

Immunogen:
Uniprot:

Q8WYB5(KAT6B_HUMAN) >>Visit HPA database.

Gene(ID):
KAT6B(23522)
Expression:
Q8WYB5 KAT6B_HUMAN:

Ubiquitously expressed, with high levels in heart, pancreas, testis and ovary.

Sequence:
MVKLANPLYTEWILEAIQKIKKQKQRPSEERICHAVSTSHGLDKKTVSEQLELSVQDGSVLKVTNKGLASYKDPDNPGRFSSVKPGTFPKSAKGSRGSCNDLRNVDWNKLLRRAIEGLEEPNGSSLKNIEKYLRSQSDLTSTTNNPAFQQRLRLGAKRAVNNGRLLKDGPQYRVNYGSLDGKGAPQYPSAFPSSLPPVSLLPHEKDQPRADPIPICSFCLGTKESNREKKPEELLSCADCGSSGHPSCLKFCPELTTNVKALRWQCIECKTCSACRVQGRNADNMLFCDSCDRGFHMECCDPPLSRMPKGMWICQVCRPKKKGRKLLHEKAAQIKRRYAKPIGRPKNKLKQRLLSVTSDEGSMNAFTGRGSPGRGQKTKVCTTPSSGHAASGKDSSSRLAVTDPTRPGATTKITTTSTYISASTLKVNKKTKGLIDGLTKFFTPSPDGRRSRGEIIDFSKHYRPRKKVSQKQSCTSHVLATGTTQKLKPPPSSLPPPTPISGQSPSSQKSSTATSSPSPQSSSSQCSVPSLSSLTTNSQLKALFDGLSHIYTTQGQSRKKGHPSYAPPKRMRRKTELSSTAKSKAHFFGKRDIRSRFISHSSSSSWGMARGSIFKAIAHFKRTTFLKKHRMLGRLKYKVTPQMGTPSPGKGSLTDGRIKPDQDDDTEIKINIKQESADVNVIGNKDVVTEEDLDVFKQAQELSWEKIECESGVEDCGRYPSVIEFGKYEIQTWYSSPYPQEYARLPKLYLCEFCLKYMKSKNILLRHSKKCGWFHPPANEIYRRKDLSVFEVDGNMSKIYCQNLCLLAKLFLDHKTLYYDVEPFLFYVLTKNDEKGCHLVGYFSKEKLCQQKYNVSCIMIMPQHQRQGFGRFLIDFSYLLSRREGQAGSPEKPLSDLGRLSYLAYWKSVILEYLYHHHERHISIKAISRATGMCPHDIATTLQHLHMIDKRDGRFVIIRREKLILSHMEKLKTCSRANELDPDSLRWTPILISNAAVSEEEREAEKEAERLMEQASCWEKEEQEILSTRANSRQSPAKVQSKNKYLHSPESRPVTGERGQLLELSKESSEEEEEEEDEEEEEEEEEEEEDEEEEEEEEEEEEEENIQSSPPRLTKPQSVAIKRKRPFVLKKKRGRKRRRINSSVTTETISETTEVLNEPFDNSDEERPMPQLEPTCEIEVEEDGRKPVLRKAFQHQPGKKRQTEEEEGKDNHCFKNADPCRNNMNDDSSNLKEGSKDNPEPLKCKQVWPKGTKRGLSKWRQNKERKTGFKLNLYTPPETPMEPDEQVTVEEQKETSEGKTSPSPIRIEEEVKETGEALLPQEENRREETCAPVSPNTSPGEKPEDDLIKPEEEEEEEEEEEEEEEEEEGEEEEGGGNVEKDPDGAKSQEKEEPEISTEKEDSARLDDHEEEEEEDEEPSHNEDHDADDEDDSHMESAEVEKEELPRESFKEVLENQETFLDLNVQPGHSNPEVLMDCGVDLTASCNSEPKELAGDPEAVPESDEEPPPGEQAQKQDQKNSKEVDTEFKEGNPATMEIDSETVQAVQSLTQESSEQDDTFQDCAETQEACRSLQNYTRADQSPQIATTLDDCQQSDHSSPVSSVHSHPGQSVRSVNSPSVPALENSYAQISPDQSAISVPSLQNMETSPMMDVPSVSDHSQQVVDSGFSDLGSIESTTENYENPSSYDSTMGGSICGNGSSQNSCSYSNLTSSSLTQSSCAVTQQMSNISGSCSMLQQTSISSPPTCSVKSPQGCVVERPPSSSQQLAQCSMAANFTPPMQLAEIPETSNANIGLYERMGQSDFGAGHYPQPSATFSLAKLQQLTNTLIDHSLPYSHSAAVTSYANSASLSTPLSNTGLVQLSQSPHSVPGGPQAQATMTPPPNLTPPPMNLPPPLLQRNMAASNIGISHSQRLQTQIASKGHISMRTKSASLSPAAATHQSQIYGRSQTVAMQGPARTLTMQRGMNMSVNLMPAPAYNVNSVNMNMNTLNAMNGYSMSQPMMNSGYHSNHGYMNQTPQYPMQMQMGMMGTQPYAQQPMQTPPHGNMMYTAPGHHGYMNTGMSKQSLNGSYMRR

Predictions

Predictions:

Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.

Species
Results
Score
Pig
100
Horse
100
Bovine
100
Sheep
100
Dog
100
Chicken
100
Rabbit
100
Xenopus
0
Zebrafish
0
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

PTMs - Q8WYB5 As Substrate

Site PTM Type Enzyme
K127 Ubiquitination
S217 Phosphorylation
T222 Phosphorylation
K223 Acetylation
S355 Phosphorylation
S362 Phosphorylation
T367 Phosphorylation
R374 Methylation
K379 Acetylation
S391 Phosphorylation
K393 Acetylation
T402 Phosphorylation
K412 Acetylation
T416 Phosphorylation
S417 Phosphorylation
T418 Phosphorylation
Y419 Phosphorylation
K440 Acetylation
K440 Ubiquitination
T443 Phosphorylation
S445 Phosphorylation
S451 Phosphorylation
K584 Acetylation
K590 Acetylation
K615 Acetylation
T640 Phosphorylation
T645 Phosphorylation
S647 Phosphorylation
S652 Phosphorylation
T654 Phosphorylation
K673 Sumoylation
Y728 Phosphorylation
Y757 Phosphorylation
K785 Ubiquitination
K815 Acetylation
Y878 Phosphorylation
S889 Phosphorylation
S998 Phosphorylation
S1027 Phosphorylation
S1035 Phosphorylation
K1038 Acetylation
K1042 Acetylation
K1044 Acetylation
S1048 Phosphorylation
S1051 Phosphorylation
T1055 Phosphorylation
T1114 Phosphorylation
K1115 Acetylation
K1245 Acetylation
R1265 Methylation
T1267 Phosphorylation
T1279 Phosphorylation
T1300 Phosphorylation
S1301 Phosphorylation
S1303 Phosphorylation
S1502 Phosphorylation
S1571 Phosphorylation
S1581 Phosphorylation
S1903 Phosphorylation
S1924 Phosphorylation
S1933 Phosphorylation
S1947 Phosphorylation

Research Backgrounds

Function:

Histone acetyltransferase which may be involved in both positive and negative regulation of transcription. Required for RUNX2-dependent transcriptional activation. May be involved in cerebral cortex development. Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity.

PTMs:

Autoacetylatedand. Autoacetylation at Lys-815 is required for proper function.

Subcellular Location:

Nucleus.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
Tissue Specificity:

Ubiquitously expressed, with high levels in heart, pancreas, testis and ovary.

Subunit Structure:

Component of the MOZ/MORF complex composed at least of ING5, KAT6A, KAT6B, MEAF6 and one of BRPF1, BRD1/BRPF2 and BRPF3. Interacts with RUNX1 and RUNX2.

Family&Domains:

The N-terminus is involved in transcriptional activation while the C-terminus is involved in transcriptional repression.

Belongs to the MYST (SAS/MOZ) family.

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