SFRS6 Antibody - #DF8824

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Product: SFRS6 Antibody
Catalog: DF8824
Description: Rabbit polyclonal antibody to SFRS6
Application: WB
Reactivity: Human, Mouse, Rat
Prediction: Chicken
Mol.Wt.: 40 kDa; 40kD(Calculated).
Uniprot: Q13247
RRID: AB_2842021

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Related Downloads
MS Report
HPLC Report
MSDS
Data Sheet
COA
Protocols
WB Handbook
IHC Protocol
IF/ICC Protocol

Product Info

Source:
Rabbit
Application:
WB 1:1000-3000
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

Reactivity:
Human,Mouse,Rat
Prediction:
Chicken(86%)
Clonality:
Polyclonal
Specificity:
SFRS6 Antibody detects endogenous levels of total SFRS6.
RRID:
AB_2842021
Cite Format: Affinity Biosciences Cat# DF8824, RRID:AB_2842021.
Conjugate:
Unconjugated.
Purification:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
Storage:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
Alias:

Fold/Unfold

arginine/serine-rich 6; B52; Epididymis secretory protein Li 91; fc17h09; HEL S 91; MGC128807; MGC5045; Pre mRNA splicing factor SRP55; Pre-mRNA-splicing factor SRP55; Serine/arginine-rich splicing factor 6; SFRS6; Splicing factor; Splicing factor arginine/serine rich 55 kDa; Splicing factor arginine/serine rich 6; SR splicing factor 6; SRP55; SRSF6; SRSF6_HUMAN; wu:faa54g02; wu:fc17h09; zgc:103497;

Immunogens

Immunogen:
Uniprot:

Q13247(SRSF6_HUMAN) >>Visit HPA database.

Gene(ID):
SRSF6(6431)
Sequence:
MPRVYIGRLSYNVREKDIQRFFSGYGRLLEVDLKNGYGFVEFEDSRDADDAVYELNGKELCGERVIVEHARGPRRDRDGYSYGSRSGGGGYSSRRTSGRDKYGPPVRTEYRLIVENLSSRCSWQDLKDFMRQAGEVTYADAHKERTNEGVIEFRSYSDMKRALDKLDGTEINGRNIRLIEDKPRTSHRRSYSGSRSRSRSRRRSRSRSRRSSRSRSRSISKSRSRSRSRSKGRSRSRSKGRKSRSKSKSKPKSDRGSHSHSRSRSKDEYEKSRSRSRSRSPKENGKGDIKSKSRSRSQSRSNSPLPVPPSKARSVSPPPKRATSRSRSRSRSKSRSRSRSSSRD

Predictions

Predictions:

Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.

Species
Results
Score
Chicken
86
Pig
0
Horse
0
Bovine
0
Sheep
0
Dog
0
Xenopus
0
Zebrafish
0
Rabbit
0
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

PTMs - Q13247 As Substrate

Site PTM Type Enzyme
S23 Phosphorylation
S45 Phosphorylation
Y53 Phosphorylation
K58 Ubiquitination
R71 Methylation
Y80 Phosphorylation
S81 Phosphorylation
Y82 Phosphorylation
S84 Phosphorylation
R85 Methylation
S86 Phosphorylation
Y91 Phosphorylation
S97 Phosphorylation
K101 Acetylation
K101 Ubiquitination
Y102 Phosphorylation
S118 Phosphorylation
S119 Phosphorylation
S122 Phosphorylation
K127 Ubiquitination
T137 Phosphorylation
Y138 Phosphorylation
K143 Ubiquitination
T146 Phosphorylation
S157 Phosphorylation
K165 Acetylation
K165 Ubiquitination
T169 Phosphorylation
K182 Acetylation
K182 Ubiquitination
S190 Phosphorylation
Y191 Phosphorylation
S192 Phosphorylation
S194 Phosphorylation
S196 Phosphorylation
S253 Phosphorylation
S257 Phosphorylation
S259 Phosphorylation
S261 Phosphorylation
S263 Phosphorylation
S265 Phosphorylation
Y269 Phosphorylation
S272 Phosphorylation
S274 Phosphorylation
K290 Acetylation
S291 Phosphorylation
S293 Phosphorylation
S295 Phosphorylation
S297 Phosphorylation
S299 Phosphorylation
S301 Phosphorylation
S303 Phosphorylation
S310 Phosphorylation
S314 Phosphorylation
S316 Phosphorylation
S326 Phosphorylation

Research Backgrounds

Function:

Plays a role in constitutive splicing and modulates the selection of alternative splice sites. Plays a role in the alternative splicing of MAPT/Tau exon 10. Binds to alternative exons of TNC pre-mRNA and promotes the expression of alternatively spliced TNC. Plays a role in wound healing and in the regulation of keratinocyte differentiation and proliferation via its role in alternative splicing.

PTMs:

Extensively phosphorylated on serine residues in the RS domain. Phosphorylated by DYRK1A, probably in the RS domain. Phosphorylation by DYRK1A modulates alternative splice site selection and inhibits the expression of MAPT/Tau exon 10.

Subcellular Location:

Nucleus. Nucleus speckle.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
Subunit Structure:

Binds SREK1/SFRS12. Interacts with DYRK1A.

Family&Domains:

Belongs to the splicing factor SR family.

Research Fields

· Genetic Information Processing > Transcription > Spliceosome.

· Human Diseases > Infectious diseases: Viral > Herpes simplex infection.

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