Ik3-1 Antibody - #DF8668
| Product: | Ik3-1 Antibody |
| Catalog: | DF8668 |
| Description: | Rabbit polyclonal antibody to Ik3-1 |
| Application: | WB IF/ICC |
| Reactivity: | Human, Mouse |
| Prediction: | Pig, Bovine, Horse, Sheep, Rabbit, Dog, Chicken, Xenopus |
| Mol.Wt.: | 67 kDa; 68kD(Calculated). |
| Uniprot: | Q8TDN4 |
| RRID: | AB_2841872 |
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Protocols
Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# DF8668, RRID:AB_2841872.
Fold/Unfold
CABL1_HUMAN; CABLES; Cables1; Cdk5 and Abl enzyme substrate 1; CDK5 and ABL1 enzyme substrate 1; FLJ35924; HsT2563; IK3 1; Ik3-1; Interactor with CDK3 1;
Immunogens
Expressed in breast, pancreas, colon, head and neck (at protein level). Strongly decreased in more than half of cases of atypical endometrial hyperplasia and in more than 90% of endometrial cancers.
- Q8TDN4 CABL1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MAAAAAAATTAACSSGSAGTDAAGASGLQQPPPQPQPQPAAAAPAQPPPEPPRKPRMDPRRRQAALSFLTNISLDGRLPPQDAEWGGGEEGGAAKPGAGGACGARTRFSLLAAAERGGCIALAAPGTPAAGLAAGSGPCLPQPSSLPPLIPGGHATVSGPGVARGFASPLGAGRASGEQWQPPRPAPLAACAQLQLLDGSGAAGQEELEEDDAFISVQVPAAAFLGSGTPGSGSGSRGRLNSFTQGILPIAFSRPTSQNYCSLEQPGQGGSTSAFEQLQRSRRRLISQRSSLETLEDIEENAPLRRCRTLSGSPRPKNFKKIHFIKNMRQHDTRNGRIVLISGRRSFCSIFSVLPYRDSTQVGDLKLDGGRQSTGAVSLKEIIGLEGVELGADGKTVSYTQFLLPTNAFGARRNTIDSTSSFSQFRNLSHRSLSIGRASGTQGSLDTGSDLGDFMDYDPNLLDDPQWPCGKHKRVLIFPSYMTTVIDYVKPSDLKKDMNETFKEKFPHIKLTLSKIRSLKREMRKLAQEDCGLEEPTVAMAFVYFEKLALKGKLNKQNRKLCAGACVLLAAKIGSDLKKHEVKHLIDKLEEKFRLNRRELIAFEFPVLVALEFALHLPEHEVMPHYRRLVQSS
Predictions
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q8TDN4 As Substrate
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| R107 | Methylation | Uniprot | |
| S109 | Phosphorylation | Uniprot | |
| S168 | Phosphorylation | Uniprot | |
| S242 | Phosphorylation | Uniprot | |
| T244 | Phosphorylation | Uniprot | |
| S257 | Phosphorylation | Uniprot | |
| Y260 | Phosphorylation | Uniprot | |
| S262 | Phosphorylation | Uniprot | |
| S287 | Phosphorylation | Uniprot | |
| S290 | Phosphorylation | Uniprot | |
| S291 | Phosphorylation | Uniprot | |
| T294 | Phosphorylation | Uniprot | |
| T309 | Phosphorylation | Uniprot | |
| S311 | Phosphorylation | Uniprot | |
| S313 | Phosphorylation | Q00526 (CDK3) | Uniprot |
| T333 | Phosphorylation | Uniprot | |
| S373 | Phosphorylation | Uniprot | |
| S378 | Phosphorylation | Uniprot | |
| T415 | Phosphorylation | Uniprot | |
| S418 | Phosphorylation | Uniprot | |
| T419 | Phosphorylation | Uniprot | |
| S421 | Phosphorylation | Uniprot | |
| S429 | Phosphorylation | Uniprot | |
| S432 | Phosphorylation | Uniprot | |
| S434 | Phosphorylation | Uniprot | |
| K515 | Ubiquitination | Uniprot | |
| S575 | Phosphorylation | Uniprot |
Research Backgrounds
Cyclin-dependent kinase binding protein. Enhances cyclin-dependent kinase tyrosine phosphorylation by nonreceptor tyrosine kinases, such as that of CDK5 by activated ABL1, which leads to increased CDK5 activity and is critical for neuronal development, and that of CDK2 by WEE1, which leads to decreased CDK2 activity and growth inhibition. Positively affects neuronal outgrowth. Plays a role as a regulator for p53/p73-induced cell death (By similarity).
Phosphorylated on Ser-313 by CCNE1/CDK3. Phosphorylated on serine/threonine residues by CDK5 and on tyrosine residues by ABL1. Also phosphorylated in vitro by CCNA1/CDK2, CCNE1/CDK2, CCNA1/CDK3 and CCNE1/CDK3 (By similarity).
Nucleus. Cytoplasm.
Note: Located in the cell body and proximal region of the developing axonal shaft of immature neurons. Located in axonal growth cone, but not in the distal part of the axon shaft or in dendritic growth cone of mature neurons (By similarity).
Expressed in breast, pancreas, colon, head and neck (at protein level). Strongly decreased in more than half of cases of atypical endometrial hyperplasia and in more than 90% of endometrial cancers.
Found in a complex with p53/TP53. Found in a number of complexes with CDK2, CDK3, CDK5, ABL1, TDRD7, CDK17, CCNA1, CCNE1 and TP73. Interacts with CDK2, CDK3, CDK5, ABL1 and TDRD7 (By similarity).
Belongs to the cyclin family.
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