CD2 Tail-binding Antibody - #DF8644

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Product: CD2 Tail-binding Antibody
Catalog: DF8644
Description: Rabbit polyclonal antibody to CD2 Tail-binding
Application: WB IF/ICC
Reactivity: Human, Mouse
Prediction: Pig, Bovine, Horse, Sheep, Rabbit, Dog
Mol.Wt.: 37 kDa; 38kD(Calculated).
Uniprot: O95400
RRID: AB_2841848

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 100ul $280 In stock
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Related Downloads
MS Report
HPLC Report
MSDS
Data Sheet
COA
Protocols
WB Handbook
IHC Protocol
IF/ICC Protocol

Product Info

Source:
Rabbit
Application:
WB 1:1000-3000, IF/ICC 1:100-1:500
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

Reactivity:
Human,Mouse
Prediction:
Pig(91%), Bovine(91%), Horse(91%), Sheep(91%), Rabbit(91%), Dog(82%)
Clonality:
Polyclonal
Specificity:
CD2 Tail-binding Antibody detects endogenous levels of total CD2 Tail-binding.
RRID:
AB_2841848
Cite Format: Affinity Biosciences Cat# DF8644, RRID:AB_2841848.
Conjugate:
Unconjugated.
Purification:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
Storage:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
Alias:

Fold/Unfold

CD2 (cytoplasmic tail) binding protein 2; CD2 antigen (cytoplasmic tail) binding protein 2; CD2 antigen cytoplasmic tail-binding protein 2; CD2 cytoplasmic domain-binding protein 2; CD2 tail-binding protein 2; CD2B2_HUMAN; Cd2bp2; FWP010; LIN1; Snu40; U5 snRNP 52K protein; U5-52K;

Immunogens

Immunogen:
Uniprot:

O95400(CD2B2_HUMAN) >>Visit HPA database.

Gene(ID):
CD2BP2(10421)
Sequence:
MPKRKVTFQGVGDEEDEDEIIVPKKKLVDPVAGSGGPGSRFKGKHSLDSDEEEDDDDGGSSKYDILASEDVEGQEAATLPSEGGVRITPFNLQEEMEEGHFDADGNYFLNRDAQIRDSWLDNIDWVKIRERPPGQRQASDSEEEDSLGQTSMSAQALLEGLLELLLPRETVAGALRRLGARGGGKGRKGPGQPSSPQRLDRLSGLADQMVARGNLGVYQETRERLAMRLKGLGCQTLGPHNPTPPPSLDMFAEELAEEELETPTPTQRGEAESRGDGLVDVMWEYKWENTGDAELYGPFTSAQMQTWVSEGYFPDGVYCRKLDPPGGQFYNSKRIDFDLYT

Predictions

Predictions:

Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.

Species
Results
Score
Pig
91
Horse
91
Bovine
91
Sheep
91
Rabbit
91
Dog
82
Xenopus
67
Zebrafish
63
Chicken
0
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

PTMs - O95400 As Substrate

Site PTM Type Enzyme
T7 Phosphorylation
K24 Ubiquitination
K26 Sumoylation
S34 Phosphorylation
S46 Phosphorylation
S49 Phosphorylation
S60 Phosphorylation
S61 Phosphorylation
Y107 Phosphorylation
S118 Phosphorylation
K127 Ubiquitination
S139 Phosphorylation
S141 Phosphorylation
T150 Phosphorylation
S151 Phosphorylation
R176 Methylation
R181 Methylation
S194 Phosphorylation
S195 Phosphorylation
T243 Phosphorylation
S247 Phosphorylation
T262 Phosphorylation
K321 Sumoylation
K321 Ubiquitination
Y330 Phosphorylation
S332 Phosphorylation
K333 Acetylation
K333 Ubiquitination
T341 Phosphorylation

Research Backgrounds

Function:

Involved in pre-mRNA splicing as component of the U5 snRNP complex that is involved in spliceosome assembly.

Subcellular Location:

Cytoplasm. Nucleus.
Note: Predominantly nuclear.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
Subunit Structure:

Component of the U5 snRNP complex composed of the U5 snRNA and at least PRPF6, PRPF8, SNRNP200, EFTUD2, SNRNP40, DDX23, TXNL4A and CD2BP2. Interacts directly with TXNL4A and PRPF6. Interacts (via GYF domain) with CD2 (via Pro-rich sequence in the cytoplasmic domain). Interacts with PQBP1.

Restrictive clause

 

Affinity Biosciences tests all products strictly. Citations are provided as a resource for additional applications that have not been validated by Affinity Biosciences. Please choose the appropriate format for each application and consult Materials and Methods sections for additional details about the use of any product in these publications.

For Research Use Only.
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