TASK-1 Antibody - #DF8620
| Product: | TASK-1 Antibody |
| Catalog: | DF8620 |
| Description: | Rabbit polyclonal antibody to TASK-1 |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Prediction: | Pig, Bovine, Horse, Sheep, Rabbit, Dog, Chicken |
| Mol.Wt.: | 43 kDa; 44kD(Calculated). |
| Uniprot: | O14649 |
| RRID: | AB_2841824 |
Related Downloads
Protocols
Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# DF8620, RRID:AB_2841824.
Fold/Unfold
Acid sensitive potassium channel protein TASK 1; Acid sensitive potassium channel protein TASK; Acid-sensitive potassium channel protein TASK-1; Cardiac two pore background K(+) channel; cTBAK 1; K2p3.1; KCNK3; KCNK3_HUMAN; OAT1; Potassium channel subfamily K member 3; potassium channel, subfamily K, member 3; Potassium inwardly rectifying channel subfamily K member 3; PPH4; rTASK; TASK 1; TASK; TBAK1; TWIK related acid sensitive K+ channel; TWIK-related acid-sensitive K(+) channel 1; Two P domain potassium channel; Two pore K(+) channel KT3.; Two pore K(+) channel KT3.1; Two pore potassium channel KT3.1;
Immunogens
Widespread expression in adult. Strongest expression in pancreas and placenta. Lower expression in brain, lung, prostate, heart, kidney, uterus, small intestine and colon.
- O14649 KCNK3_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MKRQNVRTLALIVCTFTYLLVGAAVFDALESEPELIERQRLELRQQELRARYNLSQGGYEELERVVLRLKPHKAGVQWRFAGSFYFAITVITTIGYGHAAPSTDGGKVFCMFYALLGIPLTLVMFQSLGERINTLVRYLLHRAKKGLGMRRADVSMANMVLIGFFSCISTLCIGAAAFSHYEHWTFFQAYYYCFITLTTIGFGDYVALQKDQALQTQPQYVAFSFVYILTGLTVIGAFLNLVVLRFMTMNAEDEKRDAEHRALLTRNGQAGGGGGGGSAHTTDTASSTAAAGGGGFRNVYAEVLHFQSMCSCLWYKSREKLQYSIPMIIPRDLSTSDTCVEQSHSSPGGGGRYSDTPSRRCLCSGAPRSAISSVSTGLHSLSTFRGLMKRRSSV
Predictions
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - O14649 As Substrate
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| R64 | Methylation | Uniprot | |
| Y113 | Phosphorylation | Uniprot | |
| Y300 | Phosphorylation | Uniprot | |
| Y315 | Phosphorylation | Uniprot | |
| Y323 | Phosphorylation | Uniprot | |
| T335 | Phosphorylation | Uniprot | |
| S336 | Phosphorylation | Q13464 (ROCK1) | Uniprot |
| S358 | Phosphorylation | Uniprot | |
| S364 | Phosphorylation | Uniprot | |
| S369 | Phosphorylation | Uniprot | |
| T383 | Phosphorylation | Q02156 (PRKCE) | Uniprot |
| S392 | Phosphorylation | Uniprot | |
| S393 | Phosphorylation | P51812 (RPS6KA3) , Q13464 (ROCK1) , P17612 (PRKACA) | Uniprot |
Research Backgrounds
pH-dependent, voltage-insensitive, background potassium channel protein. Rectification direction results from potassium ion concentration on either side of the membrane. Acts as an outward rectifier when external potassium concentration is low. When external potassium concentration is high, current is inward.
Cell membrane>Multi-pass membrane protein.
Widespread expression in adult. Strongest expression in pancreas and placenta. Lower expression in brain, lung, prostate, heart, kidney, uterus, small intestine and colon.
Homodimer (Probable). Heterodimer with KCNK1.
Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
Research Fields
· Organismal Systems > Endocrine system > Aldosterone synthesis and secretion.
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