Defensin beta-2 Antibody - #DF8531

(1)   (2)  
Product: Defensin beta-2 Antibody
Catalog: DF8531
Description: Rabbit polyclonal antibody to Defensin beta-2
Application: WB IF/ICC
Reactivity: Human
Mol.Wt.: 7 kDa; 7kD(Calculated).
Uniprot: O15263
RRID: AB_2841735

View similar products>>

   Size Price Inventory
 100ul $280 In stock
 200ul $350 In stock

Lead Time: Same day delivery

For pricing and ordering contact:
Local distributors
Related Downloads
MS Report
HPLC Report
MSDS
Data Sheet
COA
Protocols
WB Handbook
IHC Protocol
IF/ICC Protocol

Product Info

Source:
Rabbit
Application:
WB 1:1000-3000, IF/ICC 1:100-1:500
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

Reactivity:
Human
Clonality:
Polyclonal
Specificity:
Defensin beta-2 Antibody detects endogenous levels of total Defensin beta-2.
RRID:
AB_2841735
Cite Format: Affinity Biosciences Cat# DF8531, RRID:AB_2841735.
Conjugate:
Unconjugated.
Purification:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
Storage:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
Alias:

Fold/Unfold

BD 2; BD-2; BD2; beta 2; Beta defensin 2; Beta defensin 4B; Beta-defensin 2; Beta-defensin 4A; DEF B2; DEF B4; DEFB 102; DEFB 2; DEFB 4; DEFB102; DEFB2; DEFB2, formerly; DEFB4; DEFB4, formerly; DEFB4B; DEFB4P; Defensin; Defensin beta 2; Defensin, beta 4; Defensin, beta 4, pseudogene; Defensin, beta 4A; Defensin, beta 4B; Defensin, beta, 2, formerly; Defensin, beta, 4, formerly; DFB4A_HUMAN; HBD 2; hBD-2; HBD2; mBD-2; SAP 1; SAP1; Skin antimicrobial peptide 1; Skin-antimicrobial peptide 1;

Immunogens

Immunogen:
Uniprot:

O15263(DFB4A_HUMAN) >>Visit HPA database.

Gene(ID):
DEFB4A; DEFB4B(100289462)
Expression:
O15263 DFB4A_HUMAN:

Expressed in the skin and respiratory tract.

Sequence:
MRVLYLLFSFLFIFLMPLPGVFGGIGDPVTCLKSGAICHPVFCPRRYKQIGTCGLPGTKCCKKP

Research Backgrounds

Function:

Exhibits antimicrobial activity against Gram-negative bacteria and Gram-positive bacteria. May act as a ligand for C-C chemokine receptor CCR6. Can bind to both human and mouse CCR6 and induce chemotactic activity of CCR6-expressing cells.

Subcellular Location:

Secreted.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
Tissue Specificity:

Expressed in the skin and respiratory tract.

Family&Domains:

Belongs to the beta-defensin family. LAP/TAP subfamily.

Research Fields

· Organismal Systems > Immune system > IL-17 signaling pathway.   (View pathway)

References

1). Increased S. Aureus Colonization and Reduced Antimicrobial Peptide Expression in Erythrodermic Psoriasis. International immunopharmacology, 2024 (PubMed: 38096593) [IF=4.8]

Restrictive clause

 

Affinity Biosciences tests all products strictly. Citations are provided as a resource for additional applications that have not been validated by Affinity Biosciences. Please choose the appropriate format for each application and consult Materials and Methods sections for additional details about the use of any product in these publications.

For Research Use Only.
Not for use in diagnostic or therapeutic procedures. Not for resale. Not for distribution without written consent. Affinity Biosciences will not be held responsible for patent infringement or other violations that may occur with the use of our products. Affinity Biosciences, Affinity Biosciences Logo and all other trademarks are the property of Affinity Biosciences LTD.