Defensin beta-2 Antibody - #DF8531

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Product: Defensin beta-2 Antibody
Catalog: DF8531
Description: Rabbit polyclonal antibody to Defensin beta-2
Application: WB IF/ICC
Reactivity: Human
Mol.Wt.: 7 kDa; 7kD(Calculated).
Uniprot: O15263
RRID: AB_2841735

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Related Downloads
MS Report
HPLC Report
MSDS
Data Sheet
COA
Protocols
WB Handbook
IHC Protocol
IF/ICC Protocol

Product Info

Source:
Rabbit
Application:
WB 1:1000-3000, IF/ICC 1:100-1:500
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

Reactivity:
Human
Clonality:
Polyclonal
Specificity:
Defensin beta-2 Antibody detects endogenous levels of total Defensin beta-2.
RRID:
AB_2841735
Cite Format: Affinity Biosciences Cat# DF8531, RRID:AB_2841735.
Conjugate:
Unconjugated.
Purification:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
Storage:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
Alias:

Fold/Unfold

BD 2; BD-2; BD2; beta 2; Beta defensin 2; Beta defensin 4B; Beta-defensin 2; Beta-defensin 4A; DEF B2; DEF B4; DEFB 102; DEFB 2; DEFB 4; DEFB102; DEFB2; DEFB2, formerly; DEFB4; DEFB4, formerly; DEFB4B; DEFB4P; Defensin; Defensin beta 2; Defensin, beta 4; Defensin, beta 4, pseudogene; Defensin, beta 4A; Defensin, beta 4B; Defensin, beta, 2, formerly; Defensin, beta, 4, formerly; DFB4A_HUMAN; HBD 2; hBD-2; HBD2; mBD-2; SAP 1; SAP1; Skin antimicrobial peptide 1; Skin-antimicrobial peptide 1;

Immunogens

Immunogen:
Uniprot:

O15263(DFB4A_HUMAN) >>Visit HPA database.

Gene(ID):
DEFB4A; DEFB4B(100289462)
Expression:
O15263 DFB4A_HUMAN:

Expressed in the skin and respiratory tract.

Sequence:
MRVLYLLFSFLFIFLMPLPGVFGGIGDPVTCLKSGAICHPVFCPRRYKQIGTCGLPGTKCCKKP

Research Backgrounds

Function:

Exhibits antimicrobial activity against Gram-negative bacteria and Gram-positive bacteria. May act as a ligand for C-C chemokine receptor CCR6. Can bind to both human and mouse CCR6 and induce chemotactic activity of CCR6-expressing cells.

Subcellular Location:

Secreted.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
Tissue Specificity:

Expressed in the skin and respiratory tract.

Family&Domains:

Belongs to the beta-defensin family. LAP/TAP subfamily.

Research Fields

· Organismal Systems > Immune system > IL-17 signaling pathway.   (View pathway)

References

1). Increased S. Aureus Colonization and Reduced Antimicrobial Peptide Expression in Erythrodermic Psoriasis. International immunopharmacology, 2024 (PubMed: 38096593) [IF=5.6]

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