Product: GNRHR Antibody
Catalog: DF8428
Description: Rabbit polyclonal antibody to GNRHR
Application: WB IHC
Reactivity: Human
Prediction: Rat, Pig, Bovine, Horse, Sheep, Rabbit, Dog
Mol.Wt.: 38 kDa.; 38kD(Calculated).
Uniprot: P30968
RRID: AB_2841676

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 100ul $280 In stock
 200ul $350 In stock

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Product Info

Source:
Rabbit
Application:
IHC 1:50-1:200, WB 1:1000-3000
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

Reactivity:
Human
Prediction:
Rat(%), Pig(91%), Bovine(82%), Horse(91%), Sheep(82%), Rabbit(100%), Dog(100%)
Clonality:
Polyclonal
Specificity:
GNRHR Antibody detects endogenous levels of total GNRHR.
RRID:
AB_2841676
Cite Format: Affinity Biosciences Cat# DF8428, RRID:AB_2841676.
Conjugate:
Unconjugated.
Purification:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
Storage:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
Alias:

Fold/Unfold

GnRH receptor; GnRH-R; GNRHR; GNRHR_HUMAN; GNRHR1; Gonadotropin releasing hormone receptor; gonadotropin-releasing hormone (type 1) receptor 1; Gonadotropin-releasing hormone receptor; GRHR; HH7; leutinizing-releasing hormone receptor; lh-rh; LHRHR; LRHR; luliberin receptor; luteinizing hormone releasing hormone receptor; type I GnRH receptor;

Immunogens

Immunogen:
Uniprot:
Gene(ID):
Expression:
P30968 GNRHR_HUMAN:

Pituitary, ovary, testis, breast and prostate but not in liver and spleen.

Sequence:
MANSASPEQNQNHCSAINNSIPLMQGNLPTLTLSGKIRVTVTFFLFLLSATFNASFLLKLQKWTQKKEKGKKLSRMKLLLKHLTLANLLETLIVMPLDGMWNITVQWYAGELLCKVLSYLKLFSMYAPAFMMVVISLDRSLAITRPLALKSNSKVGQSMVGLAWILSSVFAGPQLYIFRMIHLADSSGQTKVFSQCVTHCSFSQWWHQAFYNFFTFSCLFIIPLFIMLICNAKIIFTLTRVLHQDPHELQLNQSKNNIPRARLKTLKMTVAFATSFTVCWTPYYVLGIWYWFDPEMLNRLSDPVNHFFFLFAFLNPCFDPLIYGYFSL

Predictions

Predictions:

Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.

Species
Results
Score
Rabbit
100
Dog
100
Pig
91
Horse
91
Bovine
82
Sheep
82
Xenopus
0
Zebrafish
0
Chicken
0
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

Research Backgrounds

Function:

Receptor for gonadotropin releasing hormone (GnRH) that mediates the action of GnRH to stimulate the secretion of the gonadotropic hormones luteinizing hormone (LH) and follicle-stimulating hormone (FSH). This receptor mediates its action by association with G-proteins that activate a phosphatidylinositol-calcium second messenger system. Isoform 2 may act as an inhibitor of GnRH-R signaling.

Subcellular Location:

Cell membrane>Multi-pass membrane protein.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
Tissue Specificity:

Pituitary, ovary, testis, breast and prostate but not in liver and spleen.

Family&Domains:

Belongs to the G-protein coupled receptor 1 family.

Research Fields

· Environmental Information Processing > Signaling molecules and interaction > Neuroactive ligand-receptor interaction.

Restrictive clause

 

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