PROX1 Antibody - #DF8389
| Product: | PROX1 Antibody |
| Catalog: | DF8389 |
| Description: | Rabbit polyclonal antibody to PROX1 |
| Application: | WB |
| Reactivity: | Human |
| Prediction: | Pig, Bovine, Horse, Sheep, Rabbit, Dog |
| Mol.Wt.: | 83 kDa; 83kD(Calculated). |
| Uniprot: | Q92786 |
| RRID: | AB_2841646 |
Related Downloads
Protocols
Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# DF8389, RRID:AB_2841646.
Fold/Unfold
Homeobox prospero like protein; Homeobox prospero like protein PROX1; Homeobox prospero-like protein PROX1; Prospero homeobox 1; Prospero homeobox protein 1; Prospero related homeobox 1; prospero-related homeobox gene 1; PROX 1; PROX-1; PROX1; PROX1_HUMAN; zgc:111888;
Immunogens
Most actively expressed in the developing lens. Detected also in embryonic brain, lung, liver and kidney. In adult, it is more abundant in heart and liver than in brain, skeletal muscle, kidney and pancreas.
- Q92786 PROX1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MPDHDSTALLSRQTKRRRVDIGVKRTVGTASAFFAKARATFFSAMNPQGSEQDVEYSVVQHADGEKSNVLRKLLKRANSYEDAMMPFPGATIISQLLKNNMNKNGGTEPSFQASGLSSTGSEVHQEDICSNSSRDSPPECLSPFGRPTMSQFDMDRLCDEHLRAKRARVENIIRGMSHSPSVALRGNENEREMAPQSVSPRESYRENKRKQKLPQQQQQSFQQLVSARKEQKREERRQLKQQLEDMQKQLRQLQEKFYQIYDSTDSENDEDGNLSEDSMRSEILDARAQDSVGRSDNEMCELDPGQFIDRARALIREQEMAENKPKREGNNKERDHGPNSLQPEGKHLAETLKQELNTAMSQVVDTVVKVFSAKPSRQVPQVFPPLQIPQARFAVNGENHNFHTANQRLQCFGDVIIPNPLDTFGNVQMASSTDQTEALPLVVRKNSSDQSASGPAAGGHHQPLHQSPLSATTGFTTSTFRHPFPLPLMAYPFQSPLGAPSGSFSGKDRASPESLDLTRDTTSLRTKMSSHHLSHHPCSPAHPPSTAEGLSLSLIKSECGDLQDMSEISPYSGSAMQEGLSPNHLKKAKLMFFYTRYPSSNMLKTYFSDVKFNRCITSQLIKWFSNFREFYYIQMEKYARQAINDGVTSTEELSITRDCELYRALNMHYNKANDFEVPERFLEVAQITLREFFNAIIAGKDVDPSWKKAIYKVICKLDSEVPEIFKSPNCLQELLHE
Predictions
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q92786 As Substrate
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S79 | Phosphorylation | Uniprot | |
| Y80 | Phosphorylation | Uniprot | |
| T91 | Phosphorylation | Uniprot | |
| S94 | Phosphorylation | Uniprot | |
| S177 | Phosphorylation | Uniprot | |
| S179 | Phosphorylation | Uniprot | |
| S181 | Phosphorylation | Uniprot | |
| S197 | Phosphorylation | Uniprot | |
| S199 | Phosphorylation | Uniprot | |
| S291 | Phosphorylation | Uniprot | |
| S295 | Phosphorylation | Uniprot | |
| K353 | Sumoylation | Uniprot | |
| S372 | Phosphorylation | Uniprot | |
| S511 | Phosphorylation | Uniprot | |
| S514 | Phosphorylation | Uniprot | |
| S539 | Phosphorylation | Uniprot | |
| S553 | Phosphorylation | Uniprot | |
| K556 | Sumoylation | Uniprot | |
| S557 | Phosphorylation | Uniprot | |
| K707 | Acetylation | Uniprot | |
| K708 | Acetylation | Uniprot |
Research Backgrounds
Transcription factor involved in developmental processes such as cell fate determination, gene transcriptional regulation and progenitor cell regulation in a number of organs. Plays a critical role in embryonic development and functions as a key regulatory protein in neurogenesis and the development of the heart, eye lens, liver, pancreas and the lymphatic system. Involved in the regulation of the circadian rhythm. Represses: transcription of the retinoid-related orphan receptor RORG, transcriptional activator activity of RORA and RORG and the expression of RORA/G-target genes including core clock components: ARNTL/BMAL1, NPAS2 and CRY1 and metabolic genes: AVPR1A and ELOVL3.
Nucleus.
Note: RORG promotes its nuclear localization.
Most actively expressed in the developing lens. Detected also in embryonic brain, lung, liver and kidney. In adult, it is more abundant in heart and liver than in brain, skeletal muscle, kidney and pancreas.
Interacts with RORA and RORG (via AF-2 motif).
The Prospero-type homeodomain and the adjacent Prospero domain act as a single structural unit, the Homeo-Prospero domain. The Prospero-type homeodomain is essential for repression of RORG transcriptional activator activity.
Belongs to the Prospero homeodomain family.
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