ABCD3 Antibody - #DF8315
Related Downloads
Protocols
Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# DF8315, RRID:AB_2841593.
Fold/Unfold
70 kDa peroxisomal membrane protein; ABC 43; ABC D3; ABC43; ABCD 3; Abcd3; ABCD3 protein; ABCD3_HUMAN; ATP binding cassette sub family D (ALD) member 3; ATP binding cassette sub family D member 3; ATP-binding cassette sub-family D member 3; CBAS5; dJ824O18.1 (ATP-binding cassette, sub family D (ALD), member 3 (PMP70, PXMP1)); Peroxisomal membrane protein 1 (70kD); Peroxisomal membrane protein 1 (70kD, Zellweger syndrome); Peroxisomal membrane protein 1; PMP 70; PMP70; PXMP 1; PXMP1; ZWS2;
Immunogens
- P28288 ABCD3_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MAAFSKYLTARNSSLAGAAFLLLCLLHKRRRALGLHGKKSGKPPLQNNEKEGKKERAVVDKVFFSRLIQILKIMVPRTFCKETGYLVLIAVMLVSRTYCDVWMIQNGTLIESGIIGRSRKDFKRYLLNFIAAMPLISLVNNFLKYGLNELKLCFRVRLTKYLYEEYLQAFTYYKMGNLDNRIANPDQLLTQDVEKFCNSVVDLYSNLSKPFLDIVLYIFKLTSAIGAQGPASMMAYLVVSGLFLTRLRRPIGKMTITEQKYEGEYRYVNSRLITNSEEIAFYNGNKREKQTVHSVFRKLVEHLHNFILFRFSMGFIDSIIAKYLATVVGYLVVSRPFLDLSHPRHLKSTHSELLEDYYQSGRMLLRMSQALGRIVLAGREMTRLAGFTARITELMQVLKDLNHGKYERTMVSQQEKGIEGVQVIPLIPGAGEIIIADNIIKFDHVPLATPNGDVLIRDLNFEVRSGANVLICGPNGCGKSSLFRVLGELWPLFGGRLTKPERGKLFYVPQRPYMTLGTLRDQVIYPDGREDQKRKGISDLVLKEYLDNVQLGHILEREGGWDSVQDWMDVLSGGEKQRMAMARLFYHKPQFAILDECTSAVSVDVEGYIYSHCRKVGITLFTVSHRKSLWKHHEYYLHMDGRGNYEFKQITEDTVEFGS
Predictions
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - P28288 As Substrate
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| K6 | Acetylation | Uniprot | |
| K6 | Ubiquitination | Uniprot | |
| C24 | S-Nitrosylation | Uniprot | |
| K38 | Ubiquitination | Uniprot | |
| K39 | Ubiquitination | Uniprot | |
| S40 | Phosphorylation | Uniprot | |
| K42 | Ubiquitination | Uniprot | |
| K50 | Ubiquitination | Uniprot | |
| K61 | Ubiquitination | Uniprot | |
| S65 | Phosphorylation | Uniprot | |
| S95 | Phosphorylation | Uniprot | |
| Y145 | Phosphorylation | Uniprot | |
| Y163 | Phosphorylation | Uniprot | |
| Y173 | Phosphorylation | Uniprot | |
| K253 | Ubiquitination | Uniprot | |
| K260 | Acetylation | Uniprot | |
| K260 | Ubiquitination | Uniprot | |
| K286 | Ubiquitination | Uniprot | |
| K347 | Ubiquitination | Uniprot | |
| Y357 | Phosphorylation | Uniprot | |
| Y358 | Phosphorylation | Uniprot | |
| S360 | Phosphorylation | Uniprot | |
| T388 | Phosphorylation | Uniprot | |
| K399 | Acetylation | Uniprot | |
| K399 | Ubiquitination | Uniprot | |
| K405 | Ubiquitination | Uniprot | |
| K416 | Ubiquitination | Uniprot | |
| T449 | Phosphorylation | Uniprot | |
| C472 | S-Nitrosylation | Uniprot | |
| K479 | Ubiquitination | Uniprot | |
| K504 | Ubiquitination | Uniprot | |
| Y525 | Phosphorylation | Uniprot | |
| K533 | Acetylation | Uniprot | |
| K533 | Ubiquitination | Uniprot | |
| K535 | Ubiquitination | Uniprot | |
| K543 | Ubiquitination | Uniprot | |
| Y545 | Phosphorylation | Uniprot | |
| S572 | Phosphorylation | Uniprot | |
| K576 | Ubiquitination | Uniprot | |
| K631 | Acetylation | Uniprot | |
| Y635 | Phosphorylation | Uniprot | |
| Y636 | Phosphorylation | Uniprot | |
| Y645 | Phosphorylation | Uniprot | |
| T654 | Phosphorylation | Uniprot | |
| S659 | Phosphorylation | Uniprot |
Research Backgrounds
Probable transporter involved in the transport of branched-chain fatty acids and C27 bile acids into the peroxisome; the latter function is a crucial step in bile acid biosynthesis. The nucleotide-binding fold acts as an ATP-binding subunit with ATPase activity.
Peroxisome membrane>Multi-pass membrane protein.
Can form heterodimers with ABCD1/ALD and ABCD2/ALDR. Dimerization is necessary to form an active transporter. Interacts with PEX19.
Belongs to the ABC transporter superfamily. ABCD family. Peroxisomal fatty acyl CoA transporter (TC 3.A.1.203) subfamily.
Research Fields
· Cellular Processes > Transport and catabolism > Peroxisome. (View pathway)
· Environmental Information Processing > Membrane transport > ABC transporters.
Restrictive clause
Affinity Biosciences tests all products strictly. Citations are provided as a resource for additional applications that have not been validated by Affinity Biosciences. Please choose the appropriate format for each application and consult Materials and Methods sections for additional details about the use of any product in these publications.
For Research Use Only.
Not for use in diagnostic or therapeutic procedures. Not for resale. Not for distribution without written consent. Affinity Biosciences will not be held responsible for patent infringement or other violations that may occur with the use of our products. Affinity Biosciences, Affinity Biosciences Logo and all other trademarks are the property of Affinity Biosciences LTD.