TAB3 Antibody - #DF8284
| Product: | TAB3 Antibody |
| Catalog: | DF8284 |
| Description: | Rabbit polyclonal antibody to TAB3 |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Prediction: | Pig, Horse, Sheep, Rabbit, Dog, Chicken, Xenopus |
| Mol.Wt.: | 79 kDa; 79kD(Calculated). |
| Uniprot: | Q8N5C8 |
| RRID: | AB_2841571 |
Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# DF8284, RRID:AB_2841571.
Fold/Unfold
MAP3K7IP 3; Mitogen-activated protein kinase kinase kinase 7-interacting protein 3; NAP1; NF-kappa-B-activating protein 1; NFkB activating protein 1; TAB-3; Tab3; TAB3_HUMAN; TAK1 binding protein 3; TAK1-binding protein 3; TGF-beta-activated kinase 1 and MAP3K7-binding protein 3; TGF-beta-activated kinase 1-binding protein 3;
Immunogens
Widely expressed. Constitutively overexpressed in certain tumor tissues. Isoform 1 is a major transcript while isoform 2 is a minor transcript.
- Q8N5C8 TAB3_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MAQSSPQLDIQVLHDLRQRFPEIPEGVVSQCMLQNNNNLEACCRALSQESSKYLYMEYHSPDDNRMNRNRLLHINLGIHSPSSYHPGDGAQLNGGRTLVHSSSDGHIDPQHAAGKQLICLVQEPHSAPAVVAATPNYNPFFMNEQNRSAATPPSQPPQQPSSMQTGMNPSAMQGPSPPPPPPSYMHIPRYSTNPITVTVSQNLPSGQTVPRALQILPQIPSNLYGSPGSIYIRQTSQSSSGRQTPQSTPWQSSPQGPVPHYSQRPLPVYPHQQNYQPSQYSPKQQQIPQSAYHSPPPSQCPSPFSSPQHQVQPSQLGHIFMPPSPSTTPPHPYQQGPPSYQKQGSHSVAYLPYTASSLSKGSMKKIEITVEPSQRPGTAINRSPSPISNQPSPRNQHSLYTATTPPSSSPSRGISSQPKPPFSVNPVYITYTQPTGPSCTPSPSPRVIPNPTTVFKITVGRATTENLLNLVDQEERSAAPEPIQPISVIPGSGGEKGSHKYQRSSSSGSDDYAYTQALLLHQRARMERLAKQLKLEKEELERLKSEVNGMEHDLMQRRLRRVSCTTAIPTPEEMTRLRSMNRQLQINVDCTLKEVDLLQSRGNFDPKAMNNFYDNIEPGPVVPPKPSKKDSSDPCTIERKARRISVTSKVQADIHDTQAAAADEHRTGSTQSPRTQPRDEDYEGAPWNCDSCTFLNHPALNRCEQCEMPRYT
Predictions
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q8N5C8 As Substrate
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| A2 | Acetylation | Uniprot | |
| S5 | Phosphorylation | Uniprot | |
| Y53 | Phosphorylation | Uniprot | |
| Y55 | Phosphorylation | Uniprot | |
| Y58 | Phosphorylation | Uniprot | |
| S60 | Phosphorylation | Uniprot | |
| S80 | Phosphorylation | Uniprot | |
| S82 | Phosphorylation | Uniprot | |
| S83 | Phosphorylation | Uniprot | |
| Y84 | Phosphorylation | Uniprot | |
| T97 | Phosphorylation | Uniprot | |
| S101 | Phosphorylation | Uniprot | |
| S102 | Phosphorylation | Uniprot | |
| S103 | Phosphorylation | Uniprot | |
| S126 | Phosphorylation | Uniprot | |
| T134 | Phosphorylation | Uniprot | |
| Y224 | Phosphorylation | Uniprot | |
| R264 | Methylation | Uniprot | |
| K283 | Methylation | Uniprot | |
| T354 | Phosphorylation | Uniprot | |
| S385 | Phosphorylation | Uniprot | |
| T404 | Phosphorylation | Uniprot | |
| S407 | Phosphorylation | Uniprot | |
| S408 | O-Glycosylation | Uniprot | |
| S408 | Phosphorylation | Uniprot | |
| S409 | Phosphorylation | Uniprot | |
| Y428 | Phosphorylation | Uniprot | |
| T440 | Phosphorylation | Uniprot | |
| S442 | Phosphorylation | Uniprot | |
| S444 | Phosphorylation | Uniprot | |
| S492 | Phosphorylation | Uniprot | |
| S504 | Phosphorylation | Uniprot | |
| S506 | Phosphorylation | Uniprot | |
| Y512 | Phosphorylation | Uniprot | |
| S563 | Phosphorylation | Uniprot | |
| Y613 | Phosphorylation | Uniprot | |
| S627 | Phosphorylation | Uniprot | |
| S645 | Phosphorylation | Uniprot | |
| T657 | Phosphorylation | Uniprot |
Research Backgrounds
Adapter linking MAP3K7/TAK1 and TRAF6 or TRAF2. Mediator of MAP3K7 activation, respectively in the IL1 and TNF signaling pathways. Plays a role in activation of NF-kappa-B and AP1 transcription factor. Isoform 2 may be an oncogenic factor.
Ubiquitinated; following IL1 stimulation or TRAF6 overexpression.
Phosphorylated at Ser-506 by MAPKAPK2 and MAPKAPK3 following IL1 treatment.
Widely expressed. Constitutively overexpressed in certain tumor tissues. Isoform 1 is a major transcript while isoform 2 is a minor transcript.
Interacts with TAB1, TAB2, MAP3K7, TRAF2 and TRAF6. The minimal TAB3-containing complex (TAB1-MAP3K7-TAB3) appears not to contain TAB2. However, it seems sensible to consider that TAB2 may also join this complex and may act in a cooperative manner with TAB3. Interacts with WDR34 (via the WD domains). Interacts with RBCK1. Binds 'Lys-63'-linked polyubiquitin chains. Interacts with TRIM5.
The RanBP2-type zinc finger (NZF) mediates binding to two consecutive 'Lys-63'-linked ubiquitins.
Research Fields
· Environmental Information Processing > Signal transduction > NF-kappa B signaling pathway. (View pathway)
· Environmental Information Processing > Signal transduction > TNF signaling pathway. (View pathway)
· Organismal Systems > Immune system > NOD-like receptor signaling pathway. (View pathway)
· Organismal Systems > Immune system > IL-17 signaling pathway. (View pathway)
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