DUSP3 Antibody - #DF8238
| Product: | DUSP3 Antibody |
| Catalog: | DF8238 |
| Description: | Rabbit polyclonal antibody to DUSP3 |
| Application: | WB IHC |
| Reactivity: | Human, Mouse |
| Prediction: | Pig, Bovine, Dog, Chicken |
| Mol.Wt.: | 20 kDa; 20kD(Calculated). |
| Uniprot: | P51452 |
| RRID: | AB_2841534 |
Related Downloads
Protocols
Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# DF8238, RRID:AB_2841534.
Fold/Unfold
Dual specificity phosphatase 3; Dual specificity protein phosphatase 3; Dual specificity protein phosphatase VHR; DUS3_HUMAN; DUSP3; Serine/threonine specific protein phosphatase; Vaccinia H1-related phosphatase; Vaccinia virus phosphatase VH1 related; VHR;
Immunogens
- P51452 DUS3_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MSGSFELSVQDLNDLLSDGSGCYSLPSQPCNEVTPRIYVGNASVAQDIPKLQKLGITHVLNAAEGRSFMHVNTNANFYKDSGITYLGIKANDTQEFNLSAYFERAADFIDQALAQKNGRVLVHCREGYSRSPTLVIAYLMMRQKMDVKSALSIVRQNREIGPNDGFLAQLCQLNDRLAKEGKLKP
Predictions
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - P51452 As Substrate
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S8 | Phosphorylation | Uniprot | |
| Y38 | Phosphorylation | P43403 (ZAP70) , P43405 (SYK) | Uniprot |
| K50 | Acetylation | Uniprot | |
| K50 | Ubiquitination | Uniprot | |
| K53 | Ubiquitination | Uniprot | |
| S67 | Phosphorylation | Uniprot | |
| S81 | Phosphorylation | Uniprot | |
| T93 | Phosphorylation | Uniprot | |
| Y101 | Phosphorylation | Uniprot | |
| K116 | Ubiquitination | Uniprot | |
| Y138 | Phosphorylation | P43403 (ZAP70) , P43405 (SYK) , P29597 (TYK2) | Uniprot |
| S149 | Phosphorylation | Uniprot |
Research Backgrounds
Shows activity both for tyrosine-protein phosphate and serine-protein phosphate, but displays a strong preference toward phosphotyrosines. Specifically dephosphorylates and inactivates ERK1 and ERK2.
Nucleus.
Interacts with VRK3, which seems to activate it's phosphatase activity.
Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
Research Fields
· Environmental Information Processing > Signal transduction > MAPK signaling pathway. (View pathway)
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