UGGT1 Antibody - #DF8205

(2)  
Product: UGGT1 Antibody
Catalog: DF8205
Description: Rabbit polyclonal antibody to UGGT1
Application: WB IHC
Reactivity: Human
Prediction: Pig, Zebrafish, Bovine, Horse, Dog
Mol.Wt.: 177 kDa; 177kD(Calculated).
Uniprot: Q9NYU2
RRID: AB_2841513

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Related Downloads
MS Report
HPLC Report
MSDS
Data Sheet
COA
Protocols
WB Handbook
IHC Protocol
IF/ICC Protocol

Product Info

Source:
Rabbit
Application:
WB 1:1000-3000, IHC 1:50-1:200
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

Reactivity:
Human
Prediction:
Pig(100%), Zebrafish(82%), Bovine(100%), Horse(91%), Dog(100%)
Clonality:
Polyclonal
Specificity:
UGGT1 Antibody detects endogenous levels of total UGGT1.
RRID:
AB_2841513
Cite Format: Affinity Biosciences Cat# DF8205, RRID:AB_2841513.
Conjugate:
Unconjugated.
Purification:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
Storage:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
Alias:

Fold/Unfold

GT; HUGT1; UDP glucose glycoprotein glucosyltransferase 1; UDP Glucose Glycoprotein Glucosyltransferase; UDP--Glc:glycoprotein glucosyltransferase; UDP-glucose ceramide glucosyltransferase-like 1; UDP-glucose:glycoprotein glucosyltransferase 1; UGCGL1; UGGG1; UGGG1_HUMAN; UGGT; Uggt1; UGT1; UGTR;

Immunogens

Immunogen:
Uniprot:

Q9NYU2(UGGG1_HUMAN) >>Visit HPA database.

Gene(ID):
UGGT1(56886)
Expression:
Q9NYU2 UGGG1_HUMAN:

Higher levels in pancreas, skeletal muscle, kidney, and brain. Low levels in lung and heart.

Sequence:
MGCKGDASGACAAGALPVTGVCYKMGVLVVLTVLWLFSSVKADSKAITTSLTTKWFSTPLLLEASEFLAEDSQEKFWNFVEASQNIGSSDHDGTDYSYYHAILEAAFQFLSPLQQNLFKFCLSLRSYSATIQAFQQIAADEPPPEGCNSFFSVHGKKTCESDTLEALLLTASERPKPLLFKGDHRYPSSNPESPVVIFYSEIGSEEFSNFHRQLISKSNAGKINYVFRHYIFNPRKEPVYLSGYGVELAIKSTEYKAKDDTQVKGTEVNTTVIGENDPIDEVQGFLFGKLRDLHPDLEGQLKELRKHLVESTNEMAPLKVWQLQDLSFQTAARILASPVELALVVMKDLSQNFPTKARAITKTAVSSELRTEVEENQKYFKGTLGLQPGDSALFINGLHMDLDTQDIFSLFDVLRNEARVMEGLHRLGIEGLSLHNVLKLNIQPSEADYAVDIRSPAISWVNNLEVDSRYNSWPSSLQELLRPTFPGVIRQIRKNLHNMVFIVDPAHETTAELMNTAEMFLSNHIPLRIGFIFVVNDSEDVDGMQDAGVAVLRAYNYVAQEVDDYHAFQTLTHIYNKVRTGEKVKVEHVVSVLEKKYPYVEVNSILGIDSAYDRNRKEARGYYEQTGVGPLPVVLFNGMPFEREQLDPDELETITMHKILETTTFFQRAVYLGELPHDQDVVEYIMNQPNVVPRINSRILTAERDYLDLTASNNFFVDDYARFTILDSQGKTAAVANSMNYLTKKGMSSKEIYDDSFIRPVTFWIVGDFDSPSGRQLLYDAIKHQKSSNNVRISMINNPAKEISYENTQISRAIWAALQTQTSNAAKNFITKMAKEGAAEALAAGADIAEFSVGGMDFSLFKEVFESSKMDFILSHAVYCRDVLKLKKGQRAVISNGRIIGPLEDSELFNQDDFHLLENIILKTSGQKIKSHIQQLRVEEDVASDLVMKVDALLSAQPKGDPRIEYQFFEDRHSAIKLRPKEGETYFDVVAVVDPVTREAQRLAPLLLVLAQLINMNLRVFMNCQSKLSDMPLKSFYRYVLEPEISFTSDNSFAKGPIAKFLDMPQSPLFTLNLNTPESWMVESVRTPYDLDNIYLEEVDSVVAAEYELEYLLLEGHCYDITTGQPPRGLQFTLGTSANPVIVDTIVMANLGYFQLKANPGAWILRLRKGRSEDIYRIYSHDGTDSPPDADEVVIVLNNFKSKIIKVKVQKKADMVNEDLLSDGTSENESGFWDSFKWGFTGQKTEEVKQDKDDIINIFSVASGHLYERFLRIMMLSVLKNTKTPVKFWFLKNYLSPTFKEFIPYMANEYNFQYELVQYKWPRWLHQQTEKQRIIWGYKILFLDVLFPLVVDKFLFVDADQIVRTDLKELRDFNLDGAPYGYTPFCDSRREMDGYRFWKSGYWASHLAGRKYHISALYVVDLKKFRKIAAGDRLRGQYQGLSQDPNSLSNLDQDLPNNMIHQVPIKSLPQEWLWCETWCDDASKKRAKTIDLCNNPMTKEPKLEAAVRIVPEWQDYDQEIKQLQIRFQKEKETGALYKEKTKEPSREGPQKREEL

Predictions

Predictions:

Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.

Species
Results
Score
Pig
100
Bovine
100
Dog
100
Horse
91
Zebrafish
82
Chicken
64
Sheep
57
Xenopus
50
Rabbit
0
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

PTMs - Q9NYU2 As Substrate

Site PTM Type Enzyme
Y96 Phosphorylation
Y98 Phosphorylation
Y99 Phosphorylation
K157 Ubiquitination
K217 Ubiquitination
Y240 Phosphorylation
Y244 Phosphorylation
T253 Phosphorylation
Y255 Phosphorylation
S337 Phosphorylation
K356 Ubiquitination
K362 Ubiquitination
K378 Acetylation
K378 Ubiquitination
S445 Phosphorylation
Y449 Phosphorylation
S538 Phosphorylation
Y565 Phosphorylation
T580 Phosphorylation
Y684 Phosphorylation
Y741 Phosphorylation
S748 Phosphorylation
Y779 Phosphorylation
K930 Ubiquitination
S955 Phosphorylation
K959 Ubiquitination
Y966 Phosphorylation
R972 Methylation
S1026 Phosphorylation
K1034 Acetylation
R1038 Methylation
T1145 Phosphorylation
T1241 O-Glycosylation
S1277 Phosphorylation
T1282 Phosphorylation
K1287 Ubiquitination
S1296 Phosphorylation
R1435 Methylation
Y1516 Phosphorylation

Research Backgrounds

Function:

Recognizes glycoproteins with minor folding defects. Reglucosylates single N-glycans near the misfolded part of the protein, thus providing quality control for protein folding in the endoplasmic reticulum. Reglucosylated proteins are recognized by calreticulin for recycling to the endoplasmic reticulum and refolding or degradation.

Subcellular Location:

Endoplasmic reticulum lumen. Endoplasmic reticulum-Golgi intermediate compartment.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
Tissue Specificity:

Higher levels in pancreas, skeletal muscle, kidney, and brain. Low levels in lung and heart.

Subunit Structure:

Monomer as well as in a tight complex with SELENOF. Interacts with METTL23.

Family&Domains:

The N-terminal non-catalytic domain is assumed to mediate recognition of proteins with partial folding defects.

Belongs to the glycosyltransferase 8 family.

Research Fields

· Genetic Information Processing > Folding, sorting and degradation > Protein processing in endoplasmic reticulum.   (View pathway)

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