GPR40 Antibody - #DF8146
| Product: | GPR40 Antibody |
| Catalog: | DF8146 |
| Description: | Rabbit polyclonal antibody to GPR40 |
| Application: | WB IHC |
| Reactivity: | Human, Mouse, Rat |
| Prediction: | Pig, Bovine, Sheep, Rabbit, Dog |
| Mol.Wt.: | 31 kDa; 31kD(Calculated). |
| Uniprot: | O14842 |
| RRID: | AB_2841477 |
Related Downloads
Protocols
Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# DF8146, RRID:AB_2841477.
Fold/Unfold
FFA1R; FFAR 1; Ffar1; FFAR1_HUMAN; Free fatty acid receptor 1; G protein coupled receptor 40; G-protein coupled receptor 40; GPCR40; GPR 40; GPR40;
Immunogens
- O14842 FFAR1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MDLPPQLSFGLYVAAFALGFPLNVLAIRGATAHARLRLTPSLVYALNLGCSDLLLTVSLPLKAVEALASGAWPLPASLCPVFAVAHFFPLYAGGGFLAALSAGRYLGAAFPLGYQAFRRPCYSWGVCAAIWALVLCHLGLVFGLEAPGGWLDHSNTSLGINTPVNGSPVCLEAWDPASAGPARFSLSLLLFFLPLAITAFCYVGCLRALARSGLTHRRKLRAAWVAGGALLTLLLCVGPYNASNVASFLYPNLGGSWRKLGLITGAWSVVLNPLVTGYLGRGPGLKTVCAARTQGGKSQK
Predictions
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - O14842 As Substrate
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| T31 | Phosphorylation | Uniprot | |
| S298 | Phosphorylation | Uniprot |
Research Backgrounds
G-protein coupled receptor for medium and long chain saturated and unsaturated fatty acids that plays an important role in glucose homeostasis. Fatty acid binding increases glucose-stimulated insulin secretion, and may also enhance the secretion of glucagon-like peptide 1 (GLP-1). May also play a role in bone homeostasis; receptor signaling activates pathways that inhibit osteoclast differentiation (By similarity). Ligand binding leads to a conformation change that triggers signaling via G-proteins that activate phospholipase C, leading to an increase of the intracellular calcium concentration. Seems to act through a G(q) and G(i)-mediated pathway.
Cell membrane>Multi-pass membrane protein.
Detected in brain and pancreas. Detected in pancreatic beta cells.
Belongs to the G-protein coupled receptor 1 family.
Research Fields
· Organismal Systems > Endocrine system > Insulin secretion. (View pathway)
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