OXT Antibody - #DF8139

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Product: OXT Antibody
Catalog: DF8139
Description: Rabbit polyclonal antibody to OXT
Application: WB IF/ICC
Reactivity: Human
Prediction: Pig, Bovine, Horse, Sheep, Dog, Chicken
Mol.Wt.: 12kDa; 13kD(Calculated).
Uniprot: P01178
RRID: AB_2841474

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Related Downloads
MSDS
Data Sheet
COA
Protocols
WB Handbook
IHC Protocol
IF/ICC Protocol

Product Info

Source:
Rabbit
Application:
WB 1:1000-3000, IF/ICC 1:100-1:500
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

Reactivity:
Human
Prediction:
Pig(100%), Bovine(100%), Horse(100%), Sheep(100%), Dog(100%), Chicken(86%)
Clonality:
Polyclonal
Specificity:
OXT Antibody detects endogenous levels of total OXT.
RRID:
AB_2841474
Cite Format: Affinity Biosciences Cat# DF8139, RRID:AB_2841474.
Conjugate:
Unconjugated.
Purification:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
Storage:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
Alias:

Fold/Unfold

MGC126890; MGC126892; Neurophysin 1; Neurophysin I; Ocytocin; OT; OT NPI; OXT; Oxytocin Neurophysin preproprotein; Oxytocin prepro (neurophysin I); Oxytocin prepropeptide; Oxytocin-neurophysin 1;

Immunogens

Immunogen:
Uniprot:

P01178(NEU1_HUMAN) >>Visit HPA database.

Gene(ID):
OXT(5020)
Sequence:
MAGPSLACCLLGLLALTSACYIQNCPLGGKRAAPDLDVRKCLPCGPGGKGRCFGPNICCAEELGCFVGTAEALRCQEENYLPSPCQSGQKACGSGGRCAVLGLCCSPDGCHADPACDAEATFSQR

Predictions

Predictions:

Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.

Species
Results
Score
Pig
100
Horse
100
Bovine
100
Sheep
100
Dog
100
Chicken
86
Xenopus
71
Zebrafish
71
Rabbit
0
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

Research Backgrounds

Function:

Neurophysin 1 specifically binds oxytocin.

Oxytocin causes contraction of the smooth muscle of the uterus and of the mammary gland. Acts by binding to oxytocin receptor (OXTR).

Subcellular Location:

Secreted.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
Subunit Structure:

Interacts with oxytocin receptor (Ki=1.5 nM). Interacts with vasopressin V1aR/AVPR1A (Ki=37 nM), V1bR/AVPR1B (Ki=222 nM) and V2R/AVPR2 receptors (Ki=823 nM).

Family&Domains:

Belongs to the vasopressin/oxytocin family.

Research Fields

· Organismal Systems > Endocrine system > Oxytocin signaling pathway.

Restrictive clause

 

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For Research Use Only.
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