PIP4K2A Antibody - #DF8126
| Product: | PIP4K2A Antibody |
| Catalog: | DF8126 |
| Description: | Rabbit polyclonal antibody to PIP4K2A |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Prediction: | Pig, Bovine, Horse, Sheep, Rabbit, Dog, Chicken |
| Mol.Wt.: | 46 kDa; 46kD(Calculated). |
| Uniprot: | P48426 |
| RRID: | AB_2841464 |
Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# DF8126, RRID:AB_2841464.
Fold/Unfold
1 phosphatidylinositol 4 phosphate 5 kinase 2 alpha; 1 phosphatidylinositol 4 phosphate 5 kinase; 1 phosphatidylinositol 4 phosphate kinase; 1-phosphatidylinositol-5-phosphate 4-kinase 2-alpha; 4 5 kinase B isoform; 4 5 kinase C isoform; 4 5 kinase isoform 2 alpha; Diphosphoinositide kinase 2 alpha; Diphosphoinositide kinase 2-alpha; FLJ13267; Phosphatidylinositol 4 phosphate 5 kinase type 2 alpha; Phosphatidylinositol 4 phosphate 5 kinase type II alpha; Phosphatidylinositol-5-phosphate 4-kinase type II alpha; Phosphatidylinositol-5-phosphate 4-kinase type-2 alpha; PI(5)P 4-kinase type II alpha; PI42A_HUMAN; PI5P4KA; PIP4K2A; PIP4KII-alpha; PIP5K2; PIP5K2A; PIP5KII alpha; PIP5KII-alpha; PIP5KIIA; PIP5KIII; PIPK; PtdIns; PtdIns(4)P-5-kinase B isoform; PtdIns(4)P-5-kinase C isoform; PtdIns(5)P-4-kinase isoform 2-alpha; Type II phosphatidylinositol 4 phosphate 5 kinase 53 K isoform;
Immunogens
Expressed ubiquitously, with high levels in the brain. Present in most tissues, except notably skeletal muscle and small intestine.
- P48426 PI42A_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MATPGNLGSSVLASKTKTKKKHFVAQKVKLFRASDPLLSVLMWGVNHSINELSHVQIPVMLMPDDFKAYSKIKVDNHLFNKENMPSHFKFKEYCPMVFRNLRERFGIDDQDFQNSLTRSAPLPNDSQARSGARFHTSYDKRYIIKTITSEDVAEMHNILKKYHQYIVECHGITLLPQFLGMYRLNVDGVEIYVIVTRNVFSHRLSVYRKYDLKGSTVAREASDKEKAKELPTLKDNDFINEGQKIYIDDNNKKVFLEKLKKDVEFLAQLKLMDYSLLVGIHDVERAEQEEVECEENDGEEEGESDGTHPVGTPPDSPGNTLNSSPPLAPGEFDPNIDVYGIKCHENSPRKEVYFMAIIDILTHYDAKKKAAHAAKTVKHGAGAEISTVNPEQYSKRFLDFIGHILT
Predictions
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - P48426 As Substrate
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| A2 | Acetylation | Uniprot | |
| T3 | Phosphorylation | Uniprot | |
| S10 | Phosphorylation | Uniprot | |
| S14 | Phosphorylation | Uniprot | |
| K15 | Ubiquitination | Uniprot | |
| K27 | Ubiquitination | Uniprot | |
| K81 | Ubiquitination | Uniprot | |
| K89 | Acetylation | Uniprot | |
| K89 | Methylation | Uniprot | |
| K89 | Ubiquitination | Uniprot | |
| K91 | Methylation | Uniprot | |
| K91 | Ubiquitination | Uniprot | |
| Y93 | Phosphorylation | Uniprot | |
| K145 | Acetylation | Uniprot | |
| K145 | Ubiquitination | Uniprot | |
| Y210 | Phosphorylation | Uniprot | |
| K213 | Ubiquitination | Uniprot | |
| S215 | Phosphorylation | Uniprot | |
| T216 | Phosphorylation | Uniprot | |
| K244 | Ubiquitination | Uniprot | |
| Y246 | Phosphorylation | Uniprot | |
| S304 | Phosphorylation | P68400 (CSNK2A1) | Uniprot |
| K367 | Acetylation | Uniprot | |
| K375 | Ubiquitination | Uniprot | |
| T376 | Phosphorylation | Q15139 (PRKD1) | Uniprot |
| K395 | Ubiquitination | Uniprot |
Research Backgrounds
Catalyzes the phosphorylation of phosphatidylinositol 5-phosphate (PtdIns5P) on the fourth hydroxyl of the myo-inositol ring, to form phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). May exert its function by regulating the levels of PtdIns5P, which functions in the cytosol by increasing AKT activity and in the nucleus signals through ING2. May regulate the pool of cytosolic PtdIns5P in response to the activation of tyrosine phosphorylation. May negatively regulate insulin-stimulated glucose uptake by lowering the levels of PtdIns5P. May be involved in thrombopoiesis, and the terminal maturation of megakaryocytes and regulation of their size.
Cell membrane. Nucleus. Cytoplasm.
Note: May translocate from the cytosol to the cell membrane upon activation of tyrosine phosphorylation. May translocate from the inner to the outer segments of the rod photoreceptor cells in response to light (By similarity). Localization to the nucleus is modulated by the interaction with PIP4K2B.
Expressed ubiquitously, with high levels in the brain. Present in most tissues, except notably skeletal muscle and small intestine.
Homodimer (By similarity). Interacts with PIP4K2B. Interaction with PIP4K2B may regulate localization to the nucleus.
Research Fields
· Cellular Processes > Cell motility > Regulation of actin cytoskeleton. (View pathway)
· Environmental Information Processing > Signal transduction > Phosphatidylinositol signaling system.
· Metabolism > Carbohydrate metabolism > Inositol phosphate metabolism.
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