FNTA Antibody - #DF8125

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Product: FNTA Antibody
Catalog: DF8125
Description: Rabbit polyclonal antibody to FNTA
Application: WB
Reactivity: Human, Mouse, Rat
Prediction: Pig, Bovine, Horse, Sheep, Dog, Chicken
Mol.Wt.: 44 kDa; 44kD(Calculated).
Uniprot: P49354
RRID: AB_2841463

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 100ul $280 In stock
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Related Downloads
MS Report
HPLC Report
MSDS
Data Sheet
COA
Protocols
WB Handbook
IHC Protocol
IF/ICC Protocol

Product Info

Source:
Rabbit
Application:
WB 1:1000-3000
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

Reactivity:
Human,Mouse,Rat
Prediction:
Pig(100%), Bovine(100%), Horse(100%), Sheep(100%), Dog(100%), Chicken(92%)
Clonality:
Polyclonal
Specificity:
FNTA Antibody detects endogenous levels of total FNTA.
RRID:
AB_2841463
Cite Format: Affinity Biosciences Cat# DF8125, RRID:AB_2841463.
Conjugate:
Unconjugated.
Purification:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
Storage:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
Alias:

Fold/Unfold

CAAX farnesyltransferase alpha subunit; CAAX farnesyltransferase subunit alpha; EC 2.5.1.58; EC 2.5.1.59; Farnesyl protein transferase alpha subunit; Farnesyltransferase CAAX box alpha; Farnesyltransferase, CAAX box, alpha; Fnta; FNTA_HUMAN; FPTA; FTase alpha; FTase-alpha; GGTase I alpha; GGTase-I-alpha; MGC99680; OTTHUMP00000229206; OTTHUMP00000229262; PGGT1A; Protein farnesyltransferase/geranylgeranyltransferase type I alpha subunit; Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha; Protein prenyltransferase alpha subunit repeat containing 2; PTAR2; Ras proteins prenyltransferase alpha; Ras proteins prenyltransferase subunit alpha; Type I protein geranyl geranyltransferase alpha subunit; Type I protein geranyl-geranyltransferase subunit alpha;

Immunogens

Immunogen:
Uniprot:

P49354(FNTA_HUMAN) >>Visit HPA database.

Gene(ID):
FNTA(2339)
Sequence:
MAATEGVGEAAQGGEPGQPAQPPPQPHPPPPQQQHKEEMAAEAGEAVASPMDDGFVSLDSPSYVLYRDRAEWADIDPVPQNDGPNPVVQIIYSDKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLKSLQKDLHEEMNYITAIIEEQPKNYQVWHHRRVLVEWLRDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFKLWDNELQYVDQLLKEDVRNNSVWNQRYFVISNTTGYNDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSKYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSTENDSPTNVQQ

Predictions

Predictions:

Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.

Species
Results
Score
Pig
100
Horse
100
Bovine
100
Sheep
100
Dog
100
Chicken
92
Zebrafish
75
Xenopus
67
Rabbit
0
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

PTMs - P49354 As Substrate

Site PTM Type Enzyme
A2 Acetylation
S49 Phosphorylation
S60 Phosphorylation
Y92 Phosphorylation
S93 Phosphorylation
K142 Ubiquitination
K198 Ubiquitination
K228 Ubiquitination
T247 Phosphorylation
T248 Phosphorylation
Y250 Phosphorylation
R253 Methylation
R287 Methylation
K336 Ubiquitination
K346 Ubiquitination
T350 Phosphorylation
Y358 Phosphorylation
K366 Ubiquitination
T369 Phosphorylation
S373 Phosphorylation
T375 Phosphorylation

Research Backgrounds

Function:

Essential subunit of both the farnesyltransferase and the geranylgeranyltransferase complex. Contributes to the transfer of a farnesyl or geranylgeranyl moiety from farnesyl or geranylgeranyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X. May positively regulate neuromuscular junction development downstream of MUSK via its function in RAC1 prenylation and activation.

PTMs:

Phosphorylated. Phosphorylation is mediated by MUSK upon AGRIN stimulation and results in the activation of FNTA (By similarity).

Subunit Structure:

Interacts with MUSK; the interaction is direct and mediates AGRIN-induced phosphorylation of FNTA (By similarity). Heterodimer of FNTA and FNTB (farnesyltransferase). Heterodimer of FNTA and PGGT1B (geranylgeranyltransferase).

Family&Domains:

Belongs to the protein prenyltransferase subunit alpha family.

Research Fields

· Metabolism > Metabolism of terpenoids and polyketides > Terpenoid backbone biosynthesis.

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