FDPS Antibody - #DF8118
| Product: | FDPS Antibody |
| Catalog: | DF8118 |
| Description: | Rabbit polyclonal antibody to FDPS |
| Application: | WB IHC |
| Reactivity: | Human, Mouse, Rat |
| Prediction: | Pig, Zebrafish, Bovine, Dog, Chicken, Xenopus |
| Mol.Wt.: | 48 kDa; 48kD(Calculated). |
| Uniprot: | P14324 |
| RRID: | AB_2841459 |
Related Downloads
Protocols
Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# DF8118, RRID:AB_2841459.
Fold/Unfold
(2E; (2E,6E) farnesyl diphosphate synthase; 6E)-farnesyl diphosphate synthase; Dimethylallyltranstransferase; Farnesyl diphosphate synthase; Farnesyl diphosphate synthetase; Farnesyl pyrophosphate synthase; Farnesyl pyrophosphate synthetase; Fdps; FPP synthase; FPP synthetase; FPPS; FPPS_HUMAN; FPS; Geranyltranstransferase;
Immunogens
- P14324 FPPS_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MPLSRWLRSVGVFLLPAPYWAPRERWLGSLRRPSLVHGYPVLAWHSARCWCQAWTEEPRALCSSLRMNGDQNSDVYAQEKQDFVQHFSQIVRVLTEDEMGHPEIGDAIARLKEVLEYNAIGGKYNRGLTVVVAFRELVEPRKQDADSLQRAWTVGWCVELLQAFFLVADDIMDSSLTRRGQICWYQKPGVGLDAINDANLLEACIYRLLKLYCREQPYYLNLIELFLQSSYQTEIGQTLDLLTAPQGNVDLVRFTEKRYKSIVKYKTAFYSFYLPIAAAMYMAGIDGEKEHANAKKILLEMGEFFQIQDDYLDLFGDPSVTGKIGTDIQDNKCSWLVVQCLQRATPEQYQILKENYGQKEAEKVARVKALYEELDLPAVFLQYEEDSYSHIMALIEQYAAPLPPAVFLGLARKIYKRRK
Predictions
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - P14324 As Substrate
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| K80 | Acetylation | Uniprot | |
| K80 | Ubiquitination | Uniprot | |
| S88 | Phosphorylation | Uniprot | |
| T95 | Phosphorylation | Uniprot | |
| K112 | Ubiquitination | Uniprot | |
| Y117 | Phosphorylation | Uniprot | |
| K123 | Acetylation | Uniprot | |
| K123 | Ubiquitination | Uniprot | |
| Y124 | Phosphorylation | Uniprot | |
| K142 | Ubiquitination | Uniprot | |
| K187 | Ubiquitination | Uniprot | |
| K210 | Ubiquitination | Uniprot | |
| K260 | Ubiquitination | Uniprot | |
| Y265 | Phosphorylation | Uniprot | |
| Y273 | Phosphorylation | Uniprot | |
| K332 | Ubiquitination | Uniprot | |
| S334 | Phosphorylation | Uniprot | |
| T345 | Phosphorylation | Uniprot | |
| Y349 | Phosphorylation | Uniprot | |
| K353 | Acetylation | Uniprot | |
| K353 | Ubiquitination | Uniprot | |
| K359 | Ubiquitination | Uniprot | |
| K363 | Ubiquitination | Uniprot |
Research Backgrounds
Key enzyme in isoprenoid biosynthesis which catalyzes the formation of farnesyl diphosphate (FPP), a precursor for several classes of essential metabolites including sterols, dolichols, carotenoids, and ubiquinones. FPP also serves as substrate for protein farnesylation and geranylgeranylation. Catalyzes the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate.
Cytoplasm.
Homodimer. Interacts with RSAD2.
(Microbial infection) Interacts with HTLV-1 protein p13(II).
Belongs to the FPP/GGPP synthase family.
Research Fields
· Human Diseases > Infectious diseases: Viral > Influenza A.
· Human Diseases > Infectious diseases: Viral > HTLV-I infection.
· Metabolism > Metabolism of terpenoids and polyketides > Terpenoid backbone biosynthesis.
· Metabolism > Global and overview maps > Metabolic pathways.
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