KCNJ2 Antibody - #DF8117
| Product: | KCNJ2 Antibody |
| Catalog: | DF8117 |
| Description: | Rabbit polyclonal antibody to KCNJ2 |
| Application: | WB IHC IF/ICC |
| Reactivity: | Human |
| Prediction: | Pig, Bovine, Horse, Sheep, Rabbit, Dog, Chicken |
| Mol.Wt.: | 48 kDa; 48kD(Calculated). |
| Uniprot: | P63252 |
| RRID: | AB_2841458 |
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Protocols
Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# DF8117, RRID:AB_2841458.
Fold/Unfold
Cardiac inward rectifier potassium channel; HHBIRK 1; HHBIRK1; HHIRK 1; HHIRK1; HIRK 1; hIRK1; Inward rectifier K; Inward rectifier K(+) channel Kir2.1; Inward rectifier potassium channel 2; inwardly rectifying subfamily J member 2; IRK 1; IRK-1; IRK1; IRK2_HUMAN; KCNJ2; KIR2.1; LQT 7; LQT7; Potassium channel; Potassium channel inwardly rectifying subfamily J member 2; Potassium inwardly rectifying channel J2; Potassium inwardly rectifying channel subfamily J member 2; SQT 3; SQT3;
Immunogens
Heart, brain, placenta, lung, skeletal muscle, and kidney. Diffusely distributed throughout the brain.
- P63252 KCNJ2_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MGSVRTNRYSIVSSEEDGMKLATMAVANGFGNGKSKVHTRQQCRSRFVKKDGHCNVQFINVGEKGQRYLADIFTTCVDIRWRWMLVIFCLAFVLSWLFFGCVFWLIALLHGDLDASKEGKACVSEVNSFTAAFLFSIETQTTIGYGFRCVTDECPIAVFMVVFQSIVGCIIDAFIIGAVMAKMAKPKKRNETLVFSHNAVIAMRDGKLCLMWRVGNLRKSHLVEAHVRAQLLKSRITSEGEYIPLDQIDINVGFDSGIDRIFLVSPITIVHEIDEDSPLYDLSKQDIDNADFEIVVILEGMVEATAMTTQCRSSYLANEILWGHRYEPVLFEEKHYYKVDYSRFHKTYEVPNTPLCSARDLAEKKYILSNANSFCYENEVALTSKEEDDSENGVPESTSTDTPPDIDLHNQASVPLEPRPLRRESEI
Predictions
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - P63252 As Substrate
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| G2 | Myristoylation | Uniprot | |
| Y9 | Phosphorylation | Uniprot | |
| S10 | Phosphorylation | Uniprot | |
| Y242 | Phosphorylation | Uniprot | |
| Y336 | Phosphorylation | Uniprot | |
| Y337 | Phosphorylation | Uniprot | |
| K338 | Ubiquitination | Uniprot | |
| Y341 | Phosphorylation | Uniprot | |
| S342 | Phosphorylation | Uniprot | |
| K346 | Ubiquitination | Uniprot | |
| Y366 | Phosphorylation | Uniprot | |
| S425 | Phosphorylation | P17612 (PRKACA) | Uniprot |
Research Backgrounds
Probably participates in establishing action potential waveform and excitability of neuronal and muscle tissues. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium or cesium.
S-nitrosylation increases the open probability and inward rectifying currents.
Membrane>Multi-pass membrane protein. Membrane>Lipid-anchor.
Heart, brain, placenta, lung, skeletal muscle, and kidney. Diffusely distributed throughout the brain.
Homomultimeric and heteromultimeric association with KCNJ4/Kir2.3. Association, via its PDZ-recognition domain, with LIN7A, LIN7B, LIN7C, DLG1, CASK and APBA1 plays a key role in its localization and trafficking (By similarity).
Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ2 subfamily.
Research Fields
· Organismal Systems > Nervous system > Cholinergic synapse.
· Organismal Systems > Endocrine system > Oxytocin signaling pathway.
· Organismal Systems > Endocrine system > Renin secretion.
· Organismal Systems > Digestive system > Gastric acid secretion.
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