Thymidylate Synthase Antibody - #DF8096
| Product: | Thymidylate Synthase Antibody |
| Catalog: | DF8096 |
| Description: | Rabbit polyclonal antibody to Thymidylate Synthase |
| Application: | WB |
| Reactivity: | Human, Monkey |
| Prediction: | Pig, Bovine, Horse, Sheep, Rabbit, Chicken, Xenopus |
| Mol.Wt.: | 36 kDa; 36kD(Calculated). |
| Uniprot: | P04818 |
| RRID: | AB_2841443 |
Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# DF8096, RRID:AB_2841443.
Fold/Unfold
d TMP synthase; EC 2.1.1.45; HsT422; MGC88736; OTTHUMP00000162195; Thymidylate synthase; Thymidylate synthetase; TMS; TS; TSase; Tyms; TYMS protein; Tyms thymidylate synthetase; TYSY_HUMAN;
Immunogens
- P04818 TYSY_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MPVAGSELPRRPLPPAAQERDAEPRPPHGELQYLGQIQHILRCGVRKDDRTGTGTLSVFGMQARYSLRDEFPLLTTKRVFWKGVLEELLWFIKGSTNAKELSSKGVKIWDANGSRDFLDSLGFSTREEGDLGPVYGFQWRHFGAEYRDMESDYSGQGVDQLQRVIDTIKTNPDDRRIIMCAWNPRDLPLMALPPCHALCQFYVVNSELSCQLYQRSGDMGLGVPFNIASYALLTYMIAHITGLKPGDFIHTLGDAHIYLNHIEPLKIQLQREPRPFPKLRILRKVEKIDDFKAEDFQIEGYNPHPTIKMEMAV
Predictions
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - P04818 As Substrate
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S6 | Phosphorylation | Uniprot | |
| T53 | Phosphorylation | Uniprot | |
| K77 | Ubiquitination | Uniprot | |
| K93 | Ubiquitination | Uniprot | |
| K99 | Ubiquitination | Uniprot | |
| K104 | Ubiquitination | Uniprot | |
| K107 | Ubiquitination | Uniprot | |
| S114 | Phosphorylation | Uniprot | |
| S120 | Phosphorylation | Uniprot | |
| S124 | Phosphorylation | P68400 (CSNK2A1) , P19784 (CSNK2A2) | Uniprot |
| Y135 | Phosphorylation | Uniprot | |
| Y146 | Phosphorylation | Uniprot | |
| S151 | Phosphorylation | Uniprot | |
| Y153 | Phosphorylation | Uniprot | |
| S154 | Phosphorylation | Uniprot | |
| T167 | Phosphorylation | Uniprot | |
| K169 | Ubiquitination | Uniprot | |
| K278 | Ubiquitination | Uniprot | |
| K284 | Ubiquitination | Uniprot | |
| K287 | Sumoylation | Uniprot | |
| K287 | Ubiquitination | Uniprot | |
| K292 | Sumoylation | Uniprot | |
| K292 | Ubiquitination | Uniprot | |
| K308 | Sumoylation | Uniprot | |
| K308 | Ubiquitination | Uniprot |
Research Backgrounds
Contributes to the de novo mitochondrial thymidylate biosynthesis pathway.
Nucleus. Cytoplasm. Mitochondrion. Mitochondrion matrix. Mitochondrion inner membrane.
Homodimer.
Belongs to the thymidylate synthase family.
Research Fields
· Human Diseases > Drug resistance: Antineoplastic > Antifolate resistance.
· Metabolism > Nucleotide metabolism > Pyrimidine metabolism.
· Metabolism > Metabolism of cofactors and vitamins > One carbon pool by folate.
· Metabolism > Global and overview maps > Metabolic pathways.
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For Research Use Only.
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