MYBPC3 Antibody - #DF8063
| Product: | MYBPC3 Antibody |
| Catalog: | DF8063 |
| Description: | Rabbit polyclonal antibody to MYBPC3 |
| Application: | WB IHC IF/ICC |
| Reactivity: | Human |
| Prediction: | Pig, Bovine, Rabbit, Dog |
| Mol.Wt.: | 150 kDa; 141kD(Calculated). |
| Uniprot: | Q14896 |
| RRID: | AB_2841419 |
Related Downloads
Protocols
Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# DF8063, RRID:AB_2841419.
Fold/Unfold
C protein cardiac muscle isoform; C-protein; cardiac muscle isoform; Cardiac MyBP C; Cardiac MyBP-C; cardiac-type; MYBPC3; myosin binding protein C cardiac; Myosin binding protein C cardiac type; Myosin-binding protein C; MYPC3_HUMAN;
Immunogens
- Q14896 MYPC3_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MPEPGKKPVSAFSKKPRSVEVAAGSPAVFEAETERAGVKVRWQRGGSDISASNKYGLATEGTRHTLTVREVGPADQGSYAVIAGSSKVKFDLKVIEAEKAEPMLAPAPAPAEATGAPGEAPAPAAELGESAPSPKGSSSAALNGPTPGAPDDPIGLFVMRPQDGEVTVGGSITFSARVAGASLLKPPVVKWFKGKWVDLSSKVGQHLQLHDSYDRASKVYLFELHITDAQPAFTGSYRCEVSTKDKFDCSNFNLTVHEAMGTGDLDLLSAFRRTSLAGGGRRISDSHEDTGILDFSSLLKKRDSFRTPRDSKLEAPAEEDVWEILRQAPPSEYERIAFQYGVTDLRGMLKRLKGMRRDEKKSTAFQKKLEPAYQVSKGHKIRLTVELADHDAEVKWLKNGQEIQMSGSKYIFESIGAKRTLTISQCSLADDAAYQCVVGGEKCSTELFVKEPPVLITRPLEDQLVMVGQRVEFECEVSEEGAQVKWLKDGVELTREETFKYRFKKDGQRHHLIINEAMLEDAGHYALCTSGGQALAELIVQEKKLEVYQSIADLMVGAKDQAVFKCEVSDENVRGVWLKNGKELVPDSRIKVSHIGRVHKLTIDDVTPADEADYSFVPEGFACNLSAKLHFMEVKIDFVPRQEPPKIHLDCPGRIPDTIVVVAGNKLRLDVPISGDPAPTVIWQKAITQGNKAPARPAPDAPEDTGDSDEWVFDKKLLCETEGRVRVETTKDRSIFTVEGAEKEDEGVYTVTVKNPVGEDQVNLTVKVIDVPDAPAAPKISNVGEDSCTVQWEPPAYDGGQPILGYILERKKKKSYRWMRLNFDLIQELSHEARRMIEGVVYEMRVYAVNAIGMSRPSPASQPFMPIGPPSEPTHLAVEDVSDTTVSLKWRPPERVGAGGLDGYSVEYCPEGCSEWVAALQGLTEHTSILVKDLPTGARLLFRVRAHNMAGPGAPVTTTEPVTVQEILQRPRLQLPRHLRQTIQKKVGEPVNLLIPFQGKPRPQVTWTKEGQPLAGEEVSIRNSPTDTILFIRAARRVHSGTYQVTVRIENMEDKATLVLQVVDKPSPPQDLRVTDAWGLNVALEWKPPQDVGNTELWGYTVQKADKKTMEWFTVLEHYRRTHCVVPELIIGNGYYFRVFSQNMVGFSDRAATTKEPVFIPRPGITYEPPNYKALDFSEAPSFTQPLVNRSVIAGYTAMLCCAVRGSPKPKISWFKNGLDLGEDARFRMFSKQGVLTLEIRKPCPFDGGIYVCRATNLQGEARCECRLEVRVPQ
Predictions
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q14896 As Substrate
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S18 | Phosphorylation | Uniprot | |
| T59 | Phosphorylation | Uniprot | |
| S78 | Phosphorylation | Uniprot | |
| Y79 | Phosphorylation | Uniprot | |
| S86 | Phosphorylation | Uniprot | |
| S133 | Phosphorylation | P49841 (GSK3B) | Uniprot |
| S212 | Phosphorylation | Uniprot | |
| Y213 | Phosphorylation | Uniprot | |
| T274 | Phosphorylation | Uniprot | |
| S275 | Phosphorylation | P22612 (PRKACG) , Q05655 (PRKCD) , P22694 (PRKACB) , P17612 (PRKACA) | Uniprot |
| S284 | Phosphorylation | P17612 (PRKACA) , P22694 (PRKACB) , Q05655 (PRKCD) , P22612 (PRKACG) | Uniprot |
| S286 | Phosphorylation | Uniprot | |
| T290 | Phosphorylation | Uniprot | |
| S304 | Phosphorylation | P17612 (PRKACA) , P22694 (PRKACB) , Q05655 (PRKCD) , P22612 (PRKACG) , Q15139 (PRKD1) | Uniprot |
| T307 | Phosphorylation | Uniprot | |
| S311 | Phosphorylation | P22694 (PRKACB) , P17612 (PRKACA) , P22612 (PRKACG) | Uniprot |
| Y340 | Phosphorylation | Uniprot | |
| Y373 | Phosphorylation | Uniprot | |
| K418 | Acetylation | Uniprot | |
| S424 | Phosphorylation | Uniprot | |
| S427 | Phosphorylation | Uniprot | |
| Y548 | Phosphorylation | Uniprot | |
| S550 | Phosphorylation | Uniprot | |
| S588 | Phosphorylation | Uniprot | |
| T602 | Phosphorylation | Uniprot | |
| T607 | Phosphorylation | Uniprot | |
| S708 | Phosphorylation | Uniprot | |
| S830 | Phosphorylation | Uniprot | |
| Y1043 | Phosphorylation | Uniprot | |
| S1067 | Phosphorylation | Uniprot | |
| Y1119 | Phosphorylation | Uniprot | |
| Y1135 | Phosphorylation | Uniprot | |
| Y1136 | Phosphorylation | Uniprot | |
| Y1167 | Phosphorylation | Uniprot | |
| Y1172 | Phosphorylation | Uniprot | |
| T1237 | Phosphorylation | Uniprot |
Research Backgrounds
Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F-actin and native thin filaments, and modifies the activity of actin-activated myosin ATPase. It may modulate muscle contraction or may play a more structural role.
Substrate for phosphorylation by PKA and PKC. Reversible phosphorylation appears to modulate contraction (By similarity).
Polyubiquitinated.
Belongs to the immunoglobulin superfamily. MyBP family.
Research Fields
· Human Diseases > Cardiovascular diseases > Hypertrophic cardiomyopathy (HCM).
· Human Diseases > Cardiovascular diseases > Dilated cardiomyopathy (DCM).
Restrictive clause
Affinity Biosciences tests all products strictly. Citations are provided as a resource for additional applications that have not been validated by Affinity Biosciences. Please choose the appropriate format for each application and consult Materials and Methods sections for additional details about the use of any product in these publications.
For Research Use Only.
Not for use in diagnostic or therapeutic procedures. Not for resale. Not for distribution without written consent. Affinity Biosciences will not be held responsible for patent infringement or other violations that may occur with the use of our products. Affinity Biosciences, Affinity Biosciences Logo and all other trademarks are the property of Affinity Biosciences LTD.